公开(公告)号：WO0190079A3

公开(公告)日：2002-04-04

申请号：PCT/EP0105742

申请日：2001-05-18

Applicant: BASF AG ,  AMBERG WILHELM ,  KETTSCHAU GEORG

Inventor： AMBERG WILHELM ,  KETTSCHAU GEORG

IPC: C07D251/22 ,  A61K31/44 ,  A61K31/505 ,  A61K31/506 ,  A61K31/519 ,  A61K31/53 ,  A61K31/5377 ,  A61P1/18 ,  A61P7/10 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P13/08 ,  A61P13/12 ,  A61P15/10 ,  A61P43/00 ,  C07D213/69 ,  C07D239/34 ,  C07D239/52 ,  C07D239/60 ,  C07D239/70 ,  C07D241/18 ,  C07D401/12 ,  C07D403/12 ,  C07D491/048 ,  C07D495/04

CPC classification number: C07D239/60 ,  C07D239/34

Abstract: The invention relates to carbamate and carbamide derivatives of formula (I), wherein the substituents have the meaning cited in the description. The invention also relates to the production and use thereof as endothelin receptor antagonists.

Abstract translation: 本发明涉及其中取代基在说明书所说明的式（I），以及它们的制备氨基甲酸酯和脲衍生物和作为内皮素受体拮抗剂使用。

公开(公告)号：WO0073276A3

公开(公告)日：2001-05-10

申请号：PCT/EP0004571

申请日：2000-05-19

Applicant: BASF AG ,  AMBERG WILHELM ,  KETTSCHAU GEORG

Inventor： AMBERG WILHELM ,  KETTSCHAU GEORG

IPC: C07D251/14 ,  A61K31/4418 ,  A61K31/50 ,  A61K31/505 ,  A61K31/517 ,  A61K31/519 ,  A61K31/53 ,  A61K45/00 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P11/06 ,  A61P13/08 ,  A61P35/00 ,  C07D213/64 ,  C07D213/68 ,  C07D237/14 ,  C07D239/34 ,  C07D239/52 ,  C07D251/30 ,  C07D253/06

CPC classification number: C07D251/30 ,  A61K31/505 ,  A61K31/517 ,  A61K31/519 ,  A61K31/53 ,  C07D239/34 ,  C07D239/52

Abstract: The invention relates to carboxylic acid derivatives of formula (I), whereby the substituents have the meanings as explained in the description. The invention also relates to the production and use of said novel carboxylic acid derivatives as endothelin receptor antagonists.

Abstract translation: 本发明涉及羧酸的式（I）其中取代基是在说明书，制备如所解释和作为内皮素受体拮抗剂使用的衍生物。

公开(公告)号：NO20020254A

公开(公告)日：2002-02-20

申请号：NO20020254

申请日：2002-01-17

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  KETTSCHAU GEORG

IPC: A61K31/505 ,  A61K31/506 ,  A61K31/517 ,  A61P1/18 ,  A61P5/16 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P11/06 ,  A61P13/00 ,  A61P13/12 ,  A61P35/00 ,  A61P43/00 ,  C07D239/34 ,  C07D239/47 ,  C07D239/52 ,  C07D239/56 ,  C07D239/70 ,  C07D239/80 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D473/28

CPC classification number: C07D473/28 ,  C07D239/34 ,  C07D239/52 ,  C07D239/70

公开(公告)号：DE10025728A1

公开(公告)日：2001-11-29

申请号：DE10025728

申请日：2000-05-25

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  KETTSCHAU GEORG

IPC: C07D251/22 ,  A61K31/44 ,  A61K31/505 ,  A61K31/506 ,  A61K31/519 ,  A61K31/53 ,  A61K31/5377 ,  A61P1/18 ,  A61P7/10 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P13/08 ,  A61P13/12 ,  A61P15/10 ,  A61P43/00 ,  C07D213/69 ,  C07D239/34 ,  C07D239/52 ,  C07D239/60 ,  C07D239/70 ,  C07D241/18 ,  C07D401/12 ,  C07D403/12 ,  C07D491/048 ,  C07D495/04 ,  C07D239/24 ,  C07D247/00 ,  C07D251/12

Abstract: The invention relates to carbamate and carbamide derivatives of formula (I), wherein the substituents have the meaning cited in the description. The invention also relates to the production and use thereof as endothelin receptor antagonists.

公开(公告)号：NO20013000L

公开(公告)日：2001-08-15

申请号：NO20013000

申请日：2001-06-15

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  JANSEN ROLF ,  KETTSCHAU GEORG ,  RIECHERS HARTMUT ,  BAUMANN ERNST ,  HERGENROEDER STEFAN ,  RASCHACK MANFRED ,  UNGER LILIANE

IPC: C07D251/24 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P13/08 ,  A61P13/12 ,  A61P15/10 ,  A61P35/00 ,  A61P43/00 ,  C07C229/34 ,  C07C233/87 ,  C07C235/52 ,  C07D239/34 ,  C07D251/22 ,  C07D401/12 ,  C07D491/048

Abstract: The invention relates to carboxylic acid derivatives of formula (I), in which the substituents have the following meanings: R is tetrazol or a group (a); W and Z, can be identical or different and are nitrogen or methine, provided that if W and Z are methine, then Q is nitrogen; X is nitrogen or CR ; Y is nitrogen or CR ; Q is nitrogen or CR , provided that if Q is nitrogen then X is CR and Y is CR ; R and R are identical or different and are possibly substituted phenyl or naphthyl or phenyl or naphthyl which are linked in an ortho position via a direct bond, a methlyene, ethylene or ethenylene group, an oxygen or sulfur atom or a SO2-, NH- or N-alkyl group or possibly substituted C5-C6-cycloalkyl; R is a rest (b) or (c); and R is hydrogen, C1-C4-alkyl. The invention further relates to their preparation and their use as endothelin receptor antagonists. The invention also relates to compounds of formula (II) and a structural fragment of formula (d) in which the rests R , R , R , R and R have the meanings given in claim no. 1 and to their use as structural elements in an endothelin receptor antagonist.

公开(公告)号：NO20013000A

公开(公告)日：2001-08-15

申请号：NO20013000

申请日：2001-06-15

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  JANSEN ROLF ,  KETTSCHAU GEORG ,  RIECHERS HARTMUT ,  BAUMANN ERNST ,  HERGENROEDER STEFAN ,  RASCHACK MANFRED ,  UNGER LILIANE

IPC: C07D251/24 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P13/08 ,  A61P13/12 ,  A61P15/10 ,  A61P35/00 ,  A61P43/00 ,  C07C229/34 ,  C07C233/87 ,  C07C235/52 ,  C07D239/34 ,  C07D251/22 ,  C07D401/12 ,  C07D491/048

CPC classification number: C07D251/22 ,  C07C229/34 ,  C07C235/52 ,  C07D239/34

公开(公告)号：NO20010622A

公开(公告)日：2001-02-06

申请号：NO20010622

申请日：2001-02-06

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  JANSEN ROLF ,  KETTSCHAU GEORG ,  HERGENROEDER STEFAN ,  RASCHACK MANFRED ,  UNGER LILIANE

IPC: C07D251/22 ,  A61K31/505 ,  A61K31/517 ,  A61K31/519 ,  A61K31/53 ,  A61K45/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P13/08 ,  A61P13/12 ,  A61P35/00 ,  A61P43/00 ,  C07D239/34 ,  C07D239/52 ,  C07D239/60 ,  C07D239/70 ,  C07D251/52 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D491/048 ,  C07D495/04

CPC classification number: C07D239/34 ,  C07D239/52 ,  C07D239/70 ,  C07D403/12

公开(公告)号：CA2355251A1

公开(公告)日：2000-06-29

申请号：CA2355251

申请日：1999-12-09

Applicant: BASF AG

Inventor： RASCHACK MANFRED ,  UNGER LILIANE ,  HERGENRODER STEFAN ,  BAUMANN ERNST ,  JANSEN ROLF ,  RIECHERS HARTMUT ,  KETTSCHAU GEORG ,  AMBERG WILHELM

IPC: C07D251/24 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P13/08 ,  A61P13/12 ,  A61P15/10 ,  A61P35/00 ,  A61P43/00 ,  C07C229/34 ,  C07C233/87 ,  C07C235/52 ,  C07D239/34 ,  C07D251/22 ,  C07D401/12 ,  C07D491/048 ,  C07D239/60

Abstract: The invention relates to carboxylic acid derivatives of formula (I), in whic h the substituents have the following meanings: R1 is tetrazol or a group (a); W and Z, can be identical or different and are nitrogen or methine, provided that if W and Z are methine, then Q is nitrogen; X is nitrogen or CR9; Y is nitrogen or CR10; Q is nitrogen or CR11, provided that if Q is nitrogen then X is CR5 and Y is CR10; R2 and R3 are identical or different and are possibly substituted phenyl or naphthyl or phenyl or naphthyl which are linked in an ortho position via a direct bond, a methlyene, ethylene or ethenylene group, an oxygen or sulfur atom or a SO2-, NH- or N-alkyl group or possibly substituted C5-C6-cycloalkyl; R4 is a rest (b) or (c); and R5 is hydrogen, C 1- C4-alkyl. The invention further relates to their preparation and their use a s endothelin receptor antagonists. The invention also relates to compounds of formula (II) and a structural fragment of formula (d) in which the rests R1, R2, R3, R4 and R5 have the meanings given in claim no. 1 and to their use as structural elements in an endothelin receptor antagonist.

公开(公告)号：CA2340167A1

公开(公告)日：2000-02-24

申请号：CA2340167

申请日：1999-08-07

Applicant: BASF AG

Inventor： RASCHACK MANFRED ,  UNGER LILIANE ,  AMBERG WILHELM ,  JANSEN ROLF ,  HERGENRODER STEFAN ,  KETTSCHAU GEORG

IPC: C07D251/22 ,  A61K31/505 ,  A61K31/517 ,  A61K31/519 ,  A61K31/53 ,  A61K45/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P13/08 ,  A61P13/12 ,  A61P35/00 ,  A61P43/00 ,  C07D239/34 ,  C07D239/52 ,  C07D239/60 ,  C07D239/70 ,  C07D251/52 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D491/048 ,  C07D495/04

Abstract: The invention relates to new carboxylic acid derivatives of the formula (I), where the substituents have the meaning given in the description, their production and their use as endothelin-receptor antagonists.

公开(公告)号：CZ20014312A3

公开(公告)日：2003-02-12

申请号：CZ20014312

申请日：2000-05-19

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  KETTSCHAU GEORG

IPC: C07D251/14 ,  A61K31/4418 ,  A61K31/50 ,  A61K31/505 ,  A61K31/517 ,  A61K31/519 ,  A61K31/53 ,  A61K45/00 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P11/06 ,  A61P13/08 ,  A61P35/00 ,  C07D213/64 ,  C07D213/68 ,  C07D237/14 ,  C07D239/34 ,  C07D239/52 ,  C07D251/30 ,  C07D253/06 ,  C07D251/12 ,  C07D257/04 ,  C07D403/02 ,  C07D405/02 ,  C07D413/02 ,  C07D417/02

Abstract: The invention relates to carboxylic acid derivatives of formula (I), whereby the substituents have the meanings as explained in the description. The invention also relates to the production and use of said novel carboxylic acid derivatives as endothelin receptor antagonists.