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    2.
    发明专利
    未知

    公开(公告)号：DE3869335D1

    公开(公告)日：1992-04-23

    申请号：DE3869335

    申请日：1988-11-11

    Applicant: BASF AG

    Inventor： KUEKENHOEHNER THOMAS DR ,  GOETZ NORBERT DR ,  THEOBALD HANS DR ,  KNAUS GUENTER H DR

    IPC: C07D213/48 ,  C07D213/50 ,  C07D239/26 ,  C07D261/08

    Abstract: Prodn. of heteroaromatic aldehydes or ketones of formula R-CO-R1 (I) is effected by oxidising the corresp. 1-hydroxyalkyl cpds. of formula R-C(OH)H-R1 (II) with an (in)organic hypochlorite or hypobromite in the presence of an oxidised tetraalkyl cyclic amine (III): R=5 or 6-membered heteroaryl contg. N atom R1=H or 1-20C alkyl. (III) is of formula (III): A1-A4=1-4C alkyl; Q=a gp. of formula Q1-Q3= X=an anion; n=0 or 1; Y=O, CO or CR2R3; R2 and R3=H, OH, or C- or O-bonded organic gps. opt. linked to form a 5- or 6-membered ring. Pref. R=opt. substd. isoxazolyl, pyridyl or pyrimidinyl.

    4.
    发明专利
    未知

    公开(公告)号：DE3719622A1

    公开(公告)日：1988-12-29

    申请号：DE3719622

    申请日：1987-06-12

    Applicant: BASF AG

    Inventor： KNAUS GUENTER H DR ,  ERNST HANSGEORG DR ,  THYES MARCO DR ,  PAUST JOACHIM DR

    IPC: C07C69/65 ,  C07C69/653 ,  C07F9/40

    Abstract: Alkyl gamma -halotiglates of the general formula I (I) where X is Cl or Br and R2 is alkyl of 1 to 3 carbon atoms, having a high E isomer content, are prepared by a process in which (a) the corresponding 2-methyl-but-3-enoate of the general formula II (II) is reacted with chlorine or bromine in the absence of a solvent and (b) the resulting 2-methyl-3,4-dihalobutyrate of the general formula III (III) is dehydrohalogenated by reaction with a solution of an alkali metal hydroxide in an alcohol R2OH, where R2 has the stated meaning, or in a mixture of water and an alcohol R2OH, and the products are further processed to give O,O-dialkyl- gamma -phosphonotiglates of the general formula IV (IV) where R1 is alkyl of 1 to 4 carbon atoms and R2 is alkyl of 1 to 3 carbon atoms, preferably ethyl, by reaction with a trialkyl phosphite and thermal isomerization. The process gives C5 building blocks which are extremely interesting for polyene chemistry, the said building blocks being obtained in good yields and essentially in the form of the required E isomers.

    5.
    发明专利
    未知

    公开(公告)号：DE3877423D1

    公开(公告)日：1993-02-25

    申请号：DE3877423

    申请日：1988-06-08

    Applicant: BASF AG

    Inventor： KNAUS GUENTER H DR ,  ERNST HANSGEORG DR ,  THYES MARCO DR ,  PAUST JOACHIM DR

    IPC: C07C69/65 ,  C07C69/653 ,  C07F9/40

    Abstract: Ethyl 4-(O,O-dialkylphosphono) tiglates of formula (Ia) are new (where R1 = 1-4C alkyl). Tiglates (I) are produced by (a) reacting an alkyl 2-methyl-3-butenoate of formula (II) with Cl2 or Br2 in the absence of solvent; (b) reacting the resulting 3,4-dihalo-2-methylbutyrate of formula (III) with an alkali metal hydroxide in R2OH or R2OH/H2O; (c) reacting the resulting alkyl 4-halotiglate (E/Z isomer mixt.) of formula (IV) with a trialkyl phosphite of formula (V); and (d) thermally isomerising the prod. (In the formulae R2 = 1-3C alkyl; X = Cl or Br). Prodn. of cpds. (IV) is also claimed.

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