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公开(公告)号：CZ5296A3
公开(公告)日：1996-04-17
申请号：CZ5296
申请日：1994-06-28
Applicant: BASF AG
Inventor： VIERGUTZ WOLFGANG DR , THYES MARCO DR
IPC: C07D471/08
Abstract: Described is an improved method of preparing N,N'-dibenzylbispidine by reacting N-benzylpiperidone with benzylamine and subsequent reduction.
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公开(公告)号：DE3877423D1
公开(公告)日：1993-02-25
申请号：DE3877423
申请日：1988-06-08
Applicant: BASF AG
Inventor： KNAUS GUENTER H DR , ERNST HANSGEORG DR , THYES MARCO DR , PAUST JOACHIM DR
IPC: C07C69/65 , C07C69/653 , C07F9/40
Abstract: Ethyl 4-(O,O-dialkylphosphono) tiglates of formula (Ia) are new (where R1 = 1-4C alkyl). Tiglates (I) are produced by (a) reacting an alkyl 2-methyl-3-butenoate of formula (II) with Cl2 or Br2 in the absence of solvent; (b) reacting the resulting 3,4-dihalo-2-methylbutyrate of formula (III) with an alkali metal hydroxide in R2OH or R2OH/H2O; (c) reacting the resulting alkyl 4-halotiglate (E/Z isomer mixt.) of formula (IV) with a trialkyl phosphite of formula (V); and (d) thermally isomerising the prod. (In the formulae R2 = 1-3C alkyl; X = Cl or Br). Prodn. of cpds. (IV) is also claimed.
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公开(公告)号：DE3585721D1
公开(公告)日：1992-04-30
申请号：DE3585721
申请日：1985-11-08
Applicant: BASF AG
Inventor： HIMMELE WALTER DR , WIERSDORFF WALTER-WIELANT , THYES MARCO DR
IPC: C07D211/12 , C07D211/14 , C07D211/16 , C07D295/023
Abstract: Prodn. of substd. piperidines of formula (I) comprises reacting the substd. glutardialdehyde (II) with R3NH2 and H2, at elevated temp and pressure, in presence of a hydrogenation catalyst. In the formulae, R1 and R2=alkyl, cycloalkyl, aryl or aralkyl, or together complete a 5 or 6-membered ring; one of R1 and R2 can also be H; R3=H or 1-4C alkyl.
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公开(公告)号：DE3472672D1
公开(公告)日：1988-08-18
申请号：DE3472672
申请日：1984-11-09
Applicant: BASF AG
Inventor： MUELLER JOSEF DR , WIERSDORFF WALTER-WIELANT DR , THYES MARCO DR , KIRSCHENLOHR WERNER DR , SCHERER HANS DR
IPC: C07C255/32 , C07C255/33 , C07C255/53 , C07D333/24 , C07C120/04 , C07C121/70 , C07C121/75
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公开(公告)号：DE3169653D1
公开(公告)日：1985-05-09
申请号：DE3169653
申请日：1981-06-03
Applicant: BASF AG
Inventor： THYES MARCO DR , KOENIG HORST DR , LENKE DIETER DR , LEHMANN HANS DIETER DR , GRIES JOSEF DR
IPC: A61K31/50 , A61P7/02 , A61P9/12 , C07D237/04
Abstract: Novel 6-(p-acylaminophenyl)-4,5-dihydro-3(2H)-pyridazinones, whose acyl radical is derived from a cycloalkylcarboxylic acid, processes for their preparation, pharmaceutical formulations containing these compounds, and their use as drugs in thrombo-embolic disorders and as anti-hypertensives.
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Patent Agency Ranking
公开(公告)号：DE3235370A1
公开(公告)日：1984-04-26
申请号：DE3235370
申请日：1982-09-24
Applicant: BASF AG
Inventor： ROSSY PHILLIP A DR , THYES MARCO DR , FRANKE ALBRECHT DR , KOENIG HORST PROF DR , GRIES JOSEF DR , LEHMANN HANS-DIETER PROF DR
IPC: C07D237/26 , A61K31/50
Abstract: Compounds of the formula in which R and X have the meaning given in the description, and their preparation are described. The novel substances are suitable for controlling diseases.
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公开(公告)号：DE3328286A1
公开(公告)日：1984-02-09
申请号：DE3328286
申请日：1983-08-05
Applicant: BASF AG
Inventor： THYES MARCO DR , ROSSY PHILLIP A DR , KOENIG HORST DR
IPC: C07C233/00 , C07C233/12 , C07C255/59 , C07C103/42 , C07C103/737 , C07C121/80
Abstract: Novel anilides of the formula in which R denotes a halogen atom and R denotes a hydrogen atom, an alkyl radical having 1 to 3 C atoms or a cycloalkyl radical having 3 to 6 C atoms in the ring, a process for their preparation and a process for their conversion into corresponding anilides, which carry a 3-cyano-2-methylpropionyl radical in the para-position to the amide group. These nitriles are intermediates for the preparation of pharmacologically active 4,5-dihydro-3(2H)-pyridazinones.
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公开(公告)号：CZ326096A3
公开(公告)日：1997-04-16
申请号：CZ326096
申请日：1995-04-26
Applicant: BASF AG
Inventor： AMBERG WILHELM DR , BERNARD HARALD DR , BUSCHMANN ERNST DR , HAUPT ANDREAS DR , JANITSCHKE LOTHAR DR , JANSSEN BERND DR , KARL ULRICH DR , KLING ANDREAS DR , MULLER STEFAN DR , DE POTZOLLI BERND DR , RITTER KURT DR , THYES MARCO DR , ZIERKE THOMAS DR
Abstract: PCT No. PCT/EP95/01577 Sec. 371 Date Nov. 4, 1996 Sec. 102(e) Date Nov. 4, 1996 PCT Filed Apr. 26, 1995 PCT Pub. No. WO95/30691 PCT Pub. Date Nov. 16, 1995The compound Me2Val-Val-MeVal-Pro-Pro-NHBzlxHCl is described. It is prepared from Z-Val-Val-MeVal-Pro-OR1 where Z and R1 have the meanings stated in the description. The compound shows antineoplastic activity.
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公开(公告)号：CZ9600052A3
公开(公告)日：1996-04-17
申请号：CZ5296
申请日：1994-06-28
Applicant: BASF AG
Inventor： VIERGUTZ WOLFGANG DR , THYES MARCO DR
IPC: C07D471/08
CPC classification number: C07D471/08
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公开(公告)号：AT74129T
公开(公告)日：1992-04-15
申请号：AT85114232
申请日：1985-11-08
Applicant: BASF AG
Inventor： HIMMELE WALTER DR , WIERSDORFF WALTER-WIELANT , THYES MARCO DR
IPC: C07D211/12 , C07D211/14 , C07D211/16 , C07D295/023
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