公开(公告)号：BG62067B2

公开(公告)日：1999-01-29

申请号：BG9860394

申请日：1994-02-28

Applicant: BASF AG

Inventor： SCHLECKER RAINER ,  SCHMIDT PETER ,  THIEME PETER C ,  LENKE DIETER ,  TESCHENDORF HANS-JUERGEN ,  TRAUT MARTIN ,  MUELLER CLAUS D ,  HOFMANN HANS P ,  KREISKOTT HORST

IPC: A61K31/35 ,  A61K31/352 ,  A61K31/365 ,  A61K31/37 ,  A61P25/18 ,  A61P25/24 ,  A61P25/26 ,  A61P37/08 ,  A61P43/00 ,  C07D311/08 ,  C07D311/16 ,  C07D311/78 ,  C07D311/80

Abstract: The esters of the hydroxycoumarins with sulphonic acids havethe formulawhere R1 and R2, which may be the same or different, meanhydrogen, halogen, preferably chloro- or alkyl residue with 1 to 5carbon atoms which can be substituted by -NR4R5, -OR4, -CO2R4,where R4 & R5 are the same or different and mean hydrogen atom oralkyl residue with 1 to 4 carbon atoms, or is a group ofcarboxylic acid -CO2R4, provided that R1 is not hydrogen andmethyl. when R2 means hydrogen, or together form -(CH2)n-chain,and n has the value of from 3 to 5, and R3 is alkyl residue with astraight or a branching chain with 1 to 8 carbon atoms orcyloalkyl residue with 3 to 8 carbon atoms which optionally can besubstituted by halogen, -OR3, -NR4R5, -CN or phenyl ring, alkylresidue with a straight or branching chain with 3 to 3 carbonatoms or aminogroup -NR4R5, or means a phenyl or naphthyl residuewhich optionally is mono- or polysubstituted by -OR4, -NR3R5,-NO2, halogen, -SR4, -SOR4, -SO2R4, -SCF3, -SP2CF3, -CN, -CO2R4,-COR4, -NHCOR4, -CF3, C1-C4 alkyl residue or combination of thesesubstituents. The invention also relates to method for thepreparation of the above esters and to their usage as activecomponents of pharmaceutical preparations which are valuablemedicamentous forms in the treatment of psychic disorders.6 claims

公开(公告)号：NO164771C

公开(公告)日：1990-11-14

申请号：NO844778

申请日：1984-11-30

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  SPIEGLER WOLFGANG ,  SIEGEL HARDO ,  MUELLER CLAUS D ,  PHILIPSBORN GERDA VON ,  LENKE DIETER ,  GRIES JOSEF

IPC: A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/495 ,  A61P9/06 ,  C07D207/32 ,  C07D207/333 ,  C07D213/50 ,  C07D231/12 ,  C07D307/46 ,  C07D333/22 ,  C07D409/12

公开(公告)号：DK158979B

公开(公告)日：1990-08-13

申请号：DK566684

申请日：1984-11-29

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  SPIEGLER WOLFGANG ,  SIEGEL HARDO ,  MUELLER CLAUS D ,  PHILIPSBORN GERDA VON ,  LENKE DIETER ,  GRIES JOSEF

IPC: A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/495 ,  A61P9/06 ,  C07D207/32 ,  C07D207/333 ,  C07D213/50 ,  C07D231/12 ,  C07D307/46 ,  C07D333/22 ,  C07D409/12

公开(公告)号：NO164771B

公开(公告)日：1990-08-06

申请号：NO844778

申请日：1984-11-30

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  SPIEGLER WOLFGANG ,  SIEGEL HARDO ,  MUELLER CLAUS D ,  PHILIPSBORN GERDA VON ,  LENKE DIETER ,  GRIES JOSEF

IPC: A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/495 ,  A61P9/06 ,  C07D207/32 ,  C07D207/333 ,  C07D213/50 ,  C07D231/12 ,  C07D307/46 ,  C07D333/22 ,  C07D409/12

公开(公告)号：FI77224C

公开(公告)日：1989-02-10

申请号：FI823217

申请日：1982-09-17

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  MUELLER JOSEF ,  LIETZ HELMUT ,  WIERSDORFF WALTER-WIELANT ,  HEGE HANS-GUENTHER ,  MUELLER CLAUS D ,  GRIES JOSEF ,  LENKE DIETER ,  VON PHILIPSBORN GERDA ,  RASCHACK MANFRED

IPC: A61K31/13 ,  A61K31/445 ,  A61K31/495 ,  C07C45/62 ,  C07C45/71 ,  C07C45/73 ,  C07C45/74 ,  C07C49/83 ,  C07C49/835 ,  C07C49/84 ,  C07D211/46 ,  C07D211/52 ,  C07D295/08 ,  C07D295/092 ,  C07D303/22 ,  C07D303/24 ,  C07C93/06 ,  C07C93/14 ,  C07C97/10 ,  C07C149/24 ,  C07D207/06 ,  C07D207/12 ,  C07D211/14 ,  C07D211/40

公开(公告)号：NO158675C

公开(公告)日：1988-10-19

申请号：NO821083

申请日：1982-03-31

Applicant: BASF AG

Inventor： STEINER GERD ,  FRIEDRICH LUDWIG ,  LENKE DIETER

IPC: A61K31/00 ,  A61K31/55 ,  A61P1/04 ,  C07D223/20 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D413/12 ,  C07F9/59

公开(公告)号：ZA869156B

公开(公告)日：1988-08-31

申请号：ZA869156

申请日：1986-12-04

Applicant: BASF AG

Inventor： SEITZ WERNER ,  BALDINGER VERENA ,  GRIES JOSEF ,  LENKE DIETER ,  RASCHACK MANFRED ,  RUEBSAMEN KLAUS

IPC: A61K31/135 ,  A61P1/04 ,  A61P9/00 ,  A61P9/12 ,  C07C223/02 ,  C07D317/58 ,  C07D319/18 ,  C07D325/00 ,  C07C ,  A61K

公开(公告)号：ZA8609156B

公开(公告)日：1988-08-31

申请号：ZA8609156

申请日：1986-12-04

Applicant: BASF AG

Inventor： SEITZ WERNER ,  BALDINGER VERENA ,  GRIES JOSEF ,  LENKE DIETER ,  RASCHACK MANFRED ,  RUEBSAMEN KLAUS

IPC: A61K31/135 ,  A61P1/04 ,  A61P9/00 ,  A61P9/12 ,  C07C223/02 ,  C07D317/58 ,  C07D319/18 ,  C07D325/00 ,  C07C ,  A61K

CPC classification number: C07D317/58 ,  C07D319/18 ,  Y10S514/926

公开(公告)号：NO156900C

公开(公告)日：1987-12-16

申请号：NO810480

申请日：1981-02-12

Applicant: BASF AG

Inventor： THIEME PETER C ,  FRANKE ALBRECHT ,  LENKE DIETER ,  LEHMANN HANS DIETER ,  GRIES JOSEF

IPC: A61K31/495 ,  C07D413/12 ,  A61K31/496 ,  A61P9/12 ,  C07D271/10 ,  C07D405/12

Abstract: Novel phenylpiperazinylpropanols of 1,3,4-oxadiazolylphenols and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and are useful in the treatment of hypertonia.

公开(公告)号：NO156900B

公开(公告)日：1987-09-07

申请号：NO810480

申请日：1981-02-12

Applicant: BASF AG

Inventor： THIEME PETER C ,  FRANKE ALBRECHT ,  LENKE DIETER ,  LEHMANN HANS DIETER ,  GRIES JOSEF

IPC: A61K31/495 ,  A61K31/496 ,  C07D413/12 ,  A61P9/12 ,  C07D271/10 ,  C07D405/12

Abstract: Novel phenylpiperazinylpropanols of 1,3,4-oxadiazolylphenols and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and are useful in the treatment of hypertonia.