公开(公告)号：DE2860614D1

公开(公告)日：1981-05-07

申请号：DE2860614

申请日：1978-06-19

Applicant: BASF AG

Inventor： SCHARWAECHTER PETER DR ,  GUTSCHE KLAUS DR ,  KOHLMANN WILHELM DR ,  KROEMER GERD DR

IPC: A61K31/505 ,  C07D239/48 ,  C07D239/49 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12

公开(公告)号：DE2730468A1

公开(公告)日：1979-01-18

申请号：DE2730468

申请日：1977-07-06

Applicant: BASF AG

Inventor： SCHARWAECHTER PETER DR ,  GUTSCHE KLAUS DR ,  KOHLMANN WILHELM DR ,  KROEMER GERD DR

IPC: A61K31/505 ,  A61P31/04 ,  A61P33/02 ,  C07D239/48 ,  C07D239/49

Abstract: Unsubstituted or substituted 5-phenyl- and 5-benzyl-4-amino-pyrimidine-2-imidoacid esters, their preparation, drugs containing these compounds, and their use in infectious diseases.

公开(公告)号：DE2758115A1

公开(公告)日：1979-07-05

申请号：DE2758115

申请日：1977-12-24

Applicant: BASF AG

Inventor： HARTLEBEN YORK DIPL CHEM DR ,  GUTSCHE KLAUS DIPL CHEM DR ,  SCHARWAECHTER PETER DIPL CHEM ,  KOHLMANN FRIEDRICH-WILHELM ,  KROEMER GERD DR

IPC: C07D239/48 ,  C07D239/49 ,  A61K31/505

Abstract: Pyrimidine derivs. of formula (I) are new. In (I) R1, R2 and R3 are each H, Cl, CH3 or CH3O, R4 and R5 are each CN, 2-7C alkoxycarbonyl, (I) carbanilide or carboguanidide, 2-5C aliphatic acyl, benzoyl (opt. ring substd. by Cl, CH3 or CH3O), 1-6C alkyl, allyl, phenyl (opt. substd. as benzoyl) or furyl, R4+R5 may together complete an aliphatic mono- or poly-carbocyclic or a heterocyclic ring each with 5-6 ring members, opt. substd., and with >=1 carbonyl gp. alpha to the C atom shown. Alternatively, one of R4 and R5 = H and the other is opt. substd. benzoyl. They are made by reacting the corresp. 2,4-diaminopyrimidine with R6O.CH=CR4R5 (R6 is H or 1-3C alkyl). (I) are antibacterials and esp. potentiators for sulphonamides. They are formulated conventionally at (I): sulphonamide ratio 1:10-5:1(1:1-5).

公开(公告)号：DE2732029A1

公开(公告)日：1979-02-01

申请号：DE2732029

申请日：1977-07-15

Applicant: BASF AG

Inventor： SCHARWAECHTER PETER DR ,  GUTSCHE KLAUS DR ,  KOHLMANN WILHELM DR ,  KROEMER GERD DR

IPC: A61K31/505 ,  C07D239/48 ,  C07D239/49 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12

公开(公告)号：DE2861128D1

公开(公告)日：1981-12-17

申请号：DE2861128

申请日：1978-06-19

Applicant: BASF AG

Inventor： SCHARWAECHTER PETER DR ,  GUTSCHE KLAUS DR ,  KOHLMANN WILHELM DR ,  KROEMER GERD DR

IPC: A61K31/505 ,  A61P31/04 ,  A61P33/02 ,  C07D239/48 ,  C07D239/49

Abstract: Unsubstituted or substituted 5-phenyl- and 5-benzyl-4-amino-pyrimidine-2-imidoacid esters, their preparation, drugs containing these compounds, and their use in infectious diseases.

公开(公告)号：DE2730467A1

公开(公告)日：1979-01-18

申请号：DE2730467

申请日：1977-07-06

Applicant: BASF AG

Inventor： GUTSCHE KLAUS DR ,  SCHARWAECHTER PETER DR ,  KOHLMANN WILHELM DR ,  KROEMER GERD DR

IPC: A61K31/505 ,  A61K31/535 ,  A61P31/04 ,  A61P33/02 ,  C07D239/48 ,  C07D239/49 ,  C07D403/12 ,  C07D413/12

公开(公告)号：CA1129410A

公开(公告)日：1982-08-10

申请号：CA307427

申请日：1978-07-14

Applicant: BASF AG

Inventor： SCHARWAECHTER PETER ,  GUTSCHE KLAUS ,  KOHLMANN WILHELM ,  KROEMER GERD DR

IPC: A61K31/505 ,  C07D239/48 ,  C07D239/49 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12

Abstract: 5-Benzyl-4-amino-pyrimidine-2-amidines which may or may not be substituted in the phenyl ring, and their physiologically acceptable addition salts with acids, processes for their preparation, drugs containing these compounds, and their use in infectious diseases.

公开(公告)号：DE2860928D1

公开(公告)日：1981-11-12

申请号：DE2860928

申请日：1978-06-16

Applicant: BASF AG

Inventor： GUTSCHE KLAUS DR ,  SCHARWAECHTER PETER DR ,  KOHLMANN WILHELM DR ,  KROEMER GERD DR

IPC: A61K31/505 ,  A61K31/535 ,  A61P31/04 ,  A61P33/02 ,  C07D239/48 ,  C07D239/49 ,  C07D403/12 ,  C07D413/12