公开(公告)号：WO2007017452A2

公开(公告)日：2007-02-15

申请号：PCT/EP2006064993

申请日：2006-08-02

Applicant: BASF AG ,  BOUILLO NATHALIE ,  PIEROBON MARIANNA ,  ROESSLER GERHARD ,  DOBRAWA RAINER ,  MEYER-BOEHM KATHRIN ,  LANGE RONALD FRANS MARIA

Inventor： BOUILLO NATHALIE ,  PIEROBON MARIANNA ,  ROESSLER GERHARD ,  DOBRAWA RAINER ,  MEYER-BOEHM KATHRIN ,  LANGE RONALD FRANS MARIA

CPC classification number: C08F226/06

Abstract: The invention relates to the use of copolymers which comprise a) 60 to 99 % by weight of N-vinylcaprolactam; b) 1 to 40 % by weight of at least one monomer b) selected from the group including: b1) C8-C30 alkyl esters of monoethylenically unsaturated C3-C8 carboxylic acids; b2) N-alkyl- or N,N-dialkyl-substituted amides of the acrylic acid or the methacrylic acid with C8 to C30 alkyl groups; b3) the vinyl esters of aliphatically unbranched C8-C30 carboxylic acids; b4) the C8-C30 alkyl-vinyl ethers, as solubilizers for substances that are difficult to dissolve in water.

Abstract translation: 使用包括：a）60〜99重量％的N-乙烯基己内酰胺共聚物; B）1〜40重量 - 的至少一种单体B的％）选自:. b1的选择的）的不饱和C 3 monoethylensich -C 8 - 羧酸C 8 -C 30烷基酯; b2）的N-烷基或N，N-二烷基取代的丙烯酸或甲基丙烯酸与C8至C30烷基的酰胺; B3）的脂肪族无支链C8-C30羧酸的乙烯基酯; B4）的C8-C30烷基乙烯基醚，如增溶剂为水难溶性物质。

公开(公告)号：WO2007051743A3

公开(公告)日：2007-07-26

申请号：PCT/EP2006067747

申请日：2006-10-25

Applicant: BASF AG ,  BOUILLO NATHALIE ,  PIEROBON MARIANNA ,  WIDMAIER RALF ,  DOBRAWA RAINER ,  MEYER-BOEHM KATHRIN ,  LANGE RONALD FRANS MARIA

Inventor： BOUILLO NATHALIE ,  PIEROBON MARIANNA ,  WIDMAIER RALF ,  DOBRAWA RAINER ,  MEYER-BOEHM KATHRIN ,  LANGE RONALD FRANS MARIA

IPC: A61K9/14 ,  A01N49/00 ,  A23L1/03 ,  A61K8/81 ,  A61K9/20 ,  A61K47/32 ,  C08L39/00

CPC classification number: A61K47/34 ,  A61K8/86 ,  A61K9/08 ,  A61K9/146 ,  A61K9/2077 ,  A61Q19/00 ,  C08F218/08 ,  C08F220/06

Abstract: The invention relates to the use of copolymers obtained by radically polymerising a mixture of i) 30-80 % by weight N-vinyllactam, ii) 10-50 % by weight vinylacetate, and iii) 10-50 % by weight polyether, wherein the sum of the components i), ii) and iii) is equal to 100 % by weight as solubilisers for poorly water-soluble substances.

Abstract translation: 使用通过从30我的自由基引发的聚合蛋NER混合物）得到的共聚物的80重量％的N-乙烯基内酰胺，ii）由10〜50重量％的乙酸乙烯酯，和聚醚的ⅲ）10〜50重量％ 条件是组分i）的总和，ii）和iii）等于100重量％，增溶剂为水难溶性物质。

公开(公告)号：WO2007065846A3

公开(公告)日：2007-11-29

申请号：PCT/EP2006069129

申请日：2006-11-30

Applicant: BASF AG ,  LANGE RONALD FRANS MARIA ,  BOUILLO NATHALIE ,  MUENSTER INGO ,  MATHAUER KLEMENS ,  MEYER-BOEHM KATHRIN ,  DOBRAWA RAINER

Inventor： LANGE RONALD FRANS MARIA ,  BOUILLO NATHALIE ,  MUENSTER INGO ,  MATHAUER KLEMENS ,  MEYER-BOEHM KATHRIN ,  DOBRAWA RAINER

IPC: A61K47/34 ,  A01N25/00 ,  A23L1/03 ,  A61K8/90

CPC classification number: A61K47/34 ,  A01N25/02 ,  A01N25/30 ,  A23L29/00 ,  A23L29/288 ,  A61K8/90 ,  A61K2800/54 ,  A61Q19/00

Abstract: The invention relates to the use of polyvinyl lactame-polyalkylene oxide block copolymers as solubilisers for poorly water-soluble substances.

Abstract translation: 使用聚乙烯醇 - 聚亚烷基氧化物嵌段共聚物作为增溶剂为水难溶性物质。

公开(公告)号：CA2686964A1

公开(公告)日：2008-12-11

申请号：CA2686964

申请日：2008-06-03

Applicant: BASF AG

Inventor： GEBERT SILKE ,  SCHONHERR MICHAEL ,  MEYER-BOEHM KATHRIN ,  KOLTER KARL ,  MASCHKE ANGELIKA

IPC: A61K9/00 ,  A61K9/16 ,  A61K9/20

Abstract: The invention relates to a pharmaceutical formulation in the form of aggl omerates containing A) an adjuvant consisting of a) 60 - 97 % by weight of s ugar or sugar alcohols, b) 1 - 25 % by weight of a disintegration agent c)1 - 15 % by weight of water insoluble, film-forming polymers d) 0 -15 % by wei ght of water soluble polymers, and e) 0 - 15 % by weight of additional conve ntional pharmaceutical adjuvants, the sum of the components a) to e) totalli ng 100 % by weight, and B) at least one active ingredient.

公开(公告)号：DE102005049001A1

公开(公告)日：2007-04-12

申请号：DE102005049001

申请日：2005-10-11

Applicant: BASF AG

Inventor： MEYER-BOEHM KATHRIN ,  KOLTER KARL ,  QUADIR ANISUL

IPC: A61K31/192 ,  A61K9/20

Abstract: A directly tabletable ibuprofen formulation comprising a) 50-99% by weight of crystalline ibuprofen, b) 1-15% by weight of a finely divided excipient with a surface area of at least 100 m2/g, and c) 0-40% by weight of further excipients, with the proviso that the total amount of components a) to c) corresponds to 100% by weight, where at least 50% of the surface of the ibuprofen crystals are covered with the finely divided excipient.

公开(公告)号：CA2617080A1

公开(公告)日：2007-02-01

申请号：CA2617080

申请日：2006-07-21

Applicant: BASF AG

Inventor： ANGEL MAXIMILIAN ,  MEYER-BOEHM KATHRIN

IPC: C08F226/00 ,  A23L29/00