公开(公告)号：JP2006151980A

公开(公告)日：2006-06-15

申请号：JP2005342508

申请日：2005-11-28

Applicant: Basf Ag ,  Basf Corp ,  ビー・エイ・エス・エフ、コーポレーションBASF Corporation ,  ビーエーエスエフ アクチェンゲゼルシャフトBASF Aktiengesellschaft

Inventor： LISA RUDOLPH ERNEST ,  QUADIR ANISUL ,  SCHEPER REBECCA H ,  GRZESIOWSKI PETER

IPC: A61K47/34 ,  A61K9/14 ,  A61K9/20 ,  A61K31/55

CPC classification number: A61K9/2031 ,  A61K9/146 ,  A61K9/5089 ,  A61K31/55 ,  A61K47/34 ,  B01J2/04

Abstract: PROBLEM TO BE SOLVED: To provide a method for forming a micro-prilled poloxamer used specially in the pharmaceutical manufacturing industry as a dispersant or solubilizer and a vehicle presenting sustained release properties. SOLUTION: The method for forming a micro-prilled poloxamer comprises using spraying gas at a pressure higher than ordinary pressure, a spraying nozzle at high spraying gas temperature and a high feed temperature for reducing poloxamer viscosity, and optionally, sieving after forming prills in a prilling column. The poloxamer prills are specially used in pharmaceutical preparations, being spherical with a nominal average size of preferably 106 μm or less. This method is highly cost-effective, being rapid in preparation. COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 要解决的问题：提供一种用于形成药物制造工业中特别用作分散剂或增溶剂的微粒化泊洛沙姆的方法和具有持续释放性质的载体。 解决方案：形成微孔泊洛沙姆的方法包括使用高于普通压力的喷雾气体，高喷雾气体温度下的喷雾喷嘴和降低泊洛沙姆粘度的高进料温度，以及任选地在成型后进行筛分 饲养在一个造血柱。 泊洛沙姆颗粒剂特别用于药物制剂中，为平均粒径优选为10μm以下的球形。 这种方法是非常具有成本效益的，正在迅速准备。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：WO2006135491A3

公开(公告)日：2007-06-28

申请号：PCT/US2006015236

申请日：2006-04-24

Applicant: BASF AG ,  ALI SHAUKAT ,  QUADIR ANISUL

Inventor： ALI SHAUKAT ,  QUADIR ANISUL

IPC: A61K9/00

CPC classification number: A61K31/192 ,  A61K9/7007 ,  A61K9/7015 ,  A61K9/7053 ,  A61K31/135

Abstract: A medicament carrier composition includes a medicament and a polymer component including a polyvinylpyrrolidone having a weight average molecular weight of at least 700,000 g/mol. The medicament carrier composition has a viscosity of from 500 to 5,000 cps at 250C, is substantially free of cellulose, and includes an auxiliary polymer. The medicament carrier composition is used to form a film that is also substantially free of cellulose. The film has a consistent thickness and size, and an increased flexibility and increased moisture resistance due to the polyvinylpyrrolidone. The medicament carrier composition is also used in a method of forming the film. The method includes the steps of providing the medicament and the polymer component. The method also includes the step of combining the polymer component and the medicament to form the medicament carrier composition. The method further includes the step of drying the medicament carrier composition to form the film.

Abstract translation: 药物载体组合物包含药物和包含重均分子量至少为700,000g / mol的聚乙烯吡咯烷酮的聚合物组分。 药物载体组合物在250℃下的粘度为500至5,000cps，基本上不含纤维素，并且包括辅助聚合物。 药物载体组合物用于形成也基本上不含纤维素的膜。 该膜具有一致的厚度和尺寸，以及由于聚乙烯吡咯烷酮而增加的柔性和增加的耐湿性。 药物载体组合物也用于形成膜的方法。 该方法包括提供药物和聚合物组分的步骤。 该方法还包括组合聚合物组分和药物以形成药物载体组合物的步骤。 该方法还包括干燥药物载体组合物以形成膜的步骤。

公开(公告)号：WO2008046799A2

公开(公告)日：2008-04-24

申请号：PCT/EP2007060934

申请日：2007-10-15

Applicant: BASF AG ,  QUADIR ANISUL ,  ONYIUKE CHARLES ,  ZHUANG KAI

Inventor： QUADIR ANISUL ,  ONYIUKE CHARLES ,  ZHUANG KAI

IPC: A61K9/16 ,  A61K9/20 ,  A61K31/375

CPC classification number: A61K9/1635 ,  A61K9/1688 ,  A61K9/2027 ,  A61K9/2054 ,  A61K31/375

Abstract: The present invention relates to a process for preparing granules of a hydrophilic vitamin comprising at least one binder in powder form composed of a copolymer of vinyl pyrrolidone and vinyl acetate by compacting the mixture of the hydrophilic vitamin and the binder to form pieces and comminuting the pieces to form granules of the hydrophilic vitamin and the binder. The invention further relates to the granules of a hydrophilic vitamin obtained by said process and to tablets made with said granules of a hydrophilic vitamin.

Abstract translation: 本发明涉及一种制备亲水性维生素颗粒的方法，所述亲水性维生素颗粒包含至少一种粉末形式的由乙烯基吡咯烷酮和乙酸乙烯酯的共聚物构成的粘合剂，通过压缩亲水性维生素和粘合剂的混合物形成碎片并粉碎碎片 以形成亲水性维生素和粘合剂的颗粒。 本发明还涉及通过所述方法获得的亲水性维生素颗粒和用所述颗粒亲水性维生素制成的片剂。

公开(公告)号：DE102005049001A1

公开(公告)日：2007-04-12

申请号：DE102005049001

申请日：2005-10-11

Applicant: BASF AG

Inventor： MEYER-BOEHM KATHRIN ,  KOLTER KARL ,  QUADIR ANISUL

IPC: A61K31/192 ,  A61K9/20

Abstract: A directly tabletable ibuprofen formulation comprising a) 50-99% by weight of crystalline ibuprofen, b) 1-15% by weight of a finely divided excipient with a surface area of at least 100 m2/g, and c) 0-40% by weight of further excipients, with the proviso that the total amount of components a) to c) corresponds to 100% by weight, where at least 50% of the surface of the ibuprofen crystals are covered with the finely divided excipient.

公开(公告)号：CA2611418A1

公开(公告)日：2006-12-21

申请号：CA2611418

申请日：2006-04-24

Applicant: BASF AG

Inventor： QUADIR ANISUL ,  ALI SHAUKAT

IPC: A61K9/00

公开(公告)号：AU2003220782A1

公开(公告)日：2003-09-22

申请号：AU2003220782

申请日：2003-03-07

Applicant: BASF AG

Inventor： FUSSNEGGER BERNHARD ,  QUADIR ANISUL ,  KOLTER KARL ,  GEBERT SILKE

IPC: A61K9/22 ,  A61K9/28 ,  A61K31/137 ,  A61K31/138 ,  A61K9/48 ,  A61K31/135 ,  A61K47/32

Abstract: The present invention relates to pharmaceutical single-unit administration forms provided with a sealed film coating and having delayed release, the film coating containing 30 to 100% by weight of polyvinyl acetate and the layer thickness of the film coating being 30 mum to 500 mum.