公开(公告)号：DE1644428A1

公开(公告)日：1971-04-29

申请号：DE1644428

申请日：1965-04-17

Applicant: BASF AG

Inventor： WEIDINGER HANS DR ,  MOEBIUS LEANDER DR ,  EILINGSFELD HEINZ DR

IPC: C07D271/10 ,  C07D271/113 ,  C09B1/06 ,  C09B1/22 ,  C09B1/26 ,  C09B1/58 ,  C09B1/60

Abstract: The invention comprises dyes of the formula wherein X is amino, or alkylamino; Y is hydrogen, amino, alkylamino, hydroxy, piperidinyl or alkylmercapto; Z is a linear or branched chain alkyl of up to 8 carbon atoms which may bear alkoxy, cyano, unsubstituted or substituted carbamoyl or carbalkoxy groups, or denotes an aralkyl radical or the propinyl group. The compounds are prepared by reacting a carboxylic hydrazide of the formula where Z11 is No2 or as Y, either with CS2 in a alkaline reacting agent, and simultaneously or subsequently reacting with an alkylating agent which yields Z, or with a mercapto formamide chloride of the formula where R1 and R2 are substituted or unsubstitute alkyl or aryl radicals or together with the nitrogen form a piperidinyl or morpholino ring, and subsequently reducing the nitro group to an amino group. The mercapto formamide chloride may be formed in situ by treating a dithiocarbamic ester of the formula with chlorinating agents.

公开(公告)号：CH451171A

公开(公告)日：1968-05-15

申请号：CH915665

申请日：1965-06-30

Applicant: BASF AG

Inventor： WEIDINGER HANS DR ,  EILINGSFELD HEINZ DR ,  MOEBIUS LEANDER DR

IPC: C07D271/10 ,  C07D271/113 ,  C09B1/06 ,  C09B1/22 ,  C09B1/26 ,  C09B1/58 ,  C09B1/60 ,  C07D85/54

公开(公告)号：CH406131A

公开(公告)日：1966-08-15

申请号：CH616364

申请日：1964-05-12

Applicant: BASF AG

Inventor： WEIDINGER HANS DR ,  EILINGSFELD HEINZ DR ,  MOEBIUS LEANDER DR

IPC: C09B1/20 ,  C09B1/58 ,  D06P1/20

公开(公告)号：DE3062542D1

公开(公告)日：1983-05-05

申请号：DE3062542

申请日：1980-09-27

Applicant: BASF AG

Inventor： HICKMANN ECKHARD DR ,  OESER HEINZ-GUENTER DR ,  MOEBIUS LEANDER DR

IPC: C07D401/06 ,  A61K31/47 ,  C07D209/38 ,  C07D211/22 ,  C07D215/14 ,  C07D215/50

Abstract: The present invention relates to a simplified process, which avoids organo-lithium intermediates, for the preparation of erythro- alpha -piperid-2-yl-2,8-bis-(trifluoromethyl)-quinolin-4-yl-methanol, wherein 2,8-bis-(trifluoromethyl)-quinoline-4-carboxylic acid or a salt thereof is reacted with a pyrid-2-yl-magnesium halide to give pyrid-2-yl-2,8-bis-(trifluoromethyl)-quinolin-4-yl ketone in the manner of a Grignard reaction, and this product is hydrogenated, in a conventional manner, to give erythro- alpha -piperid-2-yl-2,8-bis-(trifluoromethyl)-quinolin-4-yl-methanol.