公开(公告)号：DE3609972A1

公开(公告)日：1986-10-30

申请号：DE3609972

申请日：1986-03-25

Applicant: BASF AG

Inventor： KOBER REINER DR ,  STEGLICH WOLFGANG PROF DR ,  MILZ WOLFGANG ,  SCHRADER THOMAS ,  ENDERS DIETER PROF DR ,  PAPADOPOULOS KYRIAKOS

IPC: C07D335/02 ,  C07D409/04 ,  C07F9/40 ,  C07C103/84

Abstract: Preparation of optically active alpha -acylamino- gamma -oxocarboxylates and alpha -acylamino- gamma -oxophosphonates I (where R and R are H, organic radicals C1-C12 or linked to give a 5- or 6-membered ring; R is an organic radical; R and R are optically active or non-active organic radicals, optionally linked to form a 5- or 6-membered ring; Y is C or P; n is 0 if Y is C; n is 1 if Y is P; C is the chiral centre which is critical for optical activity), by reacting an enamine II (where A is an optically active or inactive radical of a secondary amine) with a base and an alpha -halo- alpha -acylaminocarboxylate or -phosphonate III (where Hal is Cl or Br) and subsequently eliminating the amine AH, where at least one of the radicals A, R and R is derived from an optically active secondary amine or an optically active alcohol R -OH or R -OH.