公开(公告)号：DE3824961A1

公开(公告)日：1990-01-25

申请号：DE3824961

申请日：1988-07-22

Applicant: BASF AG

Inventor： KOBER REINER DR ,  SEELE RAINER DR ,  STEGLICH WOLFGANG PROF DR ,  SCHRADER THOMAS

IPC: C07F9/30

Abstract: Process for the preparation of bis(aminomethyl)phosphinic acid I or acidic or basic salts thereof by reacting an N-hydroxymethylcarboxamide of the general formula II in which R denotes an unsubstituted or substituted alkyl, cycloalkyl, aralkyl or aryl radical, with a trivalent phosphorus-halogen compound, if appropriate in the presence of an alkali bromide, alkaline earth bromide, ammonium bromide, alkali metal iodide, alkaline earth metal iodide or ammonium iodide, to give bis(aminomethyl)phosphinic acid derivatives of the general formula III and these are converted into bis(aminomethyl)phosphinic acid in the form of its acidic or basic salts by hydrolytic elimination of the acyl radicals and, if appropriate, liberating the free acid I.

公开(公告)号：DE3609972A1

公开(公告)日：1986-10-30

申请号：DE3609972

申请日：1986-03-25

Applicant: BASF AG

Inventor： KOBER REINER DR ,  STEGLICH WOLFGANG PROF DR ,  MILZ WOLFGANG ,  SCHRADER THOMAS ,  ENDERS DIETER PROF DR ,  PAPADOPOULOS KYRIAKOS

IPC: C07D335/02 ,  C07D409/04 ,  C07F9/40 ,  C07C103/84

Abstract: Preparation of optically active alpha -acylamino- gamma -oxocarboxylates and alpha -acylamino- gamma -oxophosphonates I (where R and R are H, organic radicals C1-C12 or linked to give a 5- or 6-membered ring; R is an organic radical; R and R are optically active or non-active organic radicals, optionally linked to form a 5- or 6-membered ring; Y is C or P; n is 0 if Y is C; n is 1 if Y is P; C is the chiral centre which is critical for optical activity), by reacting an enamine II (where A is an optically active or inactive radical of a secondary amine) with a base and an alpha -halo- alpha -acylaminocarboxylate or -phosphonate III (where Hal is Cl or Br) and subsequently eliminating the amine AH, where at least one of the radicals A, R and R is derived from an optically active secondary amine or an optically active alcohol R -OH or R -OH.