公开(公告)号：JPH1087659A

公开(公告)日：1998-04-07

申请号：JP22474097

申请日：1997-08-21

Applicant: BASF AG

Inventor： ROSENAU THOMAS ,  HABICHER WOLF-DIETER ,  STREICHER HARALD

IPC: A23L1/30 ,  A23L33/15 ,  A61K8/00 ,  A61K8/49 ,  A61K8/67 ,  A61K31/35 ,  A61K31/375 ,  A61P43/00 ,  A61Q19/00 ,  C07D407/12 ,  C07F9/6558 ,  C08K5/15 ,  C08K5/1545 ,  C09K15/08 ,  C09K15/32 ,  A23L1/302 ,  A61K7/00 ,  A61K7/48

Abstract: PROBLEM TO BE SOLVED: To obtain a new compound useful as a medicine, a cosmetic, a food additive, a biological antioxidant and a stabilizer. SOLUTION: This compound is represented by formula I [R is a 1-12C hydrocarbon, a (substituted)cycloalkyl, a heterocyclic ring, etc.; R is an 8-30C hydrocarbon, a (substituted)alkyl, etc.; R is PO3 H2 or glycosidyl; R , R and R are each H, an alkyl, an aryl, an aralkyl, etc.; R is H, or CO-R (R is H, a 1-20C aliphatic or phenylvinyl)]. The compound represented by formula I is obtained by reacting a 5-halogenomethyl-chroman represented by formula II (X is Br or Cl) with an alkali(ne earth) metallic salt of ascorbic acid or an ascorbic acid derivative represented by formula III. The compound represented by formula I can be used to thereby stabilize an organic substance, especially a food, medicine, a cosmetic or a plastic to injurious actions of oxygen, heat and/or light.

公开(公告)号：WO9703974A3

公开(公告)日：1997-03-06

申请号：PCT/EP9603008

申请日：1996-07-10

Applicant: BASF AG ,  AUMUELLER ALEXANDER ,  TRAUTH HUBERT ,  HABICHER WOLF DIETER ,  ROSENAU THOMAS

Inventor： AUMUELLER ALEXANDER ,  TRAUTH HUBERT ,  HABICHER WOLF-DIETER ,  ROSENAU THOMAS

IPC: C07D311/72 ,  C08K5/00 ,  C08K5/15 ,  C09K15/06 ,  C09K15/20 ,  C09K15/22

CPC classification number: C07D311/72

Abstract: Disclosed are chroman derivatives of general formula (I), wherein R1 is an unsubstituted or substituted C¿6?-C20 aryl or aryloxy radical, a C1-C20 alkoxy group, -CN, -COOR?3¿, -COOH or -CONH¿2; R?2 is a C-organic radical with 8 - 30 C atoms, and R3 is an alkyl radical with 1-20 C atoms in which the carbon chain can be interrupted in the ether function by oxygen atoms. Diclosed also are a method for preparing the claimed compounds (I), the use of these compounds as stabilizers of organic material, specifically plastics, against the effects of light, oxygen and heat as well as stabilizer mixtures and plastics and other organic materials containing the claimed compounds (I).

公开(公告)号：DE69600566D1

公开(公告)日：1998-10-01

申请号：DE69600566

申请日：1996-11-27

Applicant: BASF AG

Inventor： CHEN CHEN-LOUNG ,  ROSENAU THOMAS ,  HABICHER WOLF-DIETER DR

IPC: C07D213/74 ,  C07C209/08 ,  C07C209/60 ,  C07C211/05 ,  C07C211/07 ,  C07C211/08 ,  C07C211/17 ,  C07C211/21 ,  C07C211/27 ,  C07C211/45 ,  C07C211/48 ,  C07C211/58 ,  C07C213/04 ,  C07C215/16 ,  C07C227/08 ,  C07C229/10 ,  C07C229/14 ,  C07C229/18 ,  C07C229/24 ,  C07D311/72 ,  C07K1/06 ,  C07K5/062

Abstract: The present invention relates to a process for preparing protected amines or amino acids. The invention furthermore relates to the use of tocopheryl radicals or radicals derived therefrom as protective groups for amines and amino acids, and to compounds obtained in this process as intermediates and to processes for preparing dipeptides and oligopeptides.

公开(公告)号：DE19633560A1

公开(公告)日：1998-02-26

申请号：DE19633560

申请日：1996-08-21

Applicant: BASF AG

Inventor： ROSENAU THOMAS ,  HABICHER WOLF-DIETER ,  STREICHER HARALD

IPC: A23L33/15 ,  A61K8/00 ,  A61K8/49 ,  A61K8/67 ,  A61K31/35 ,  A61K31/375 ,  A61P43/00 ,  A61Q19/00 ,  C07D407/12 ,  A23L1/30 ,  C07F9/6558 ,  C08K5/15 ,  C08K5/1545 ,  C09K15/08 ,  C09K15/32 ,  A23L1/302 ,  A23L3/3544 ,  C09K15/06

Abstract: Chromanyl-ascorbic acid derivatives of formula (I) are new. R1 = 1-12C aliphatic hydrocarbyl; or 4-12C cycloalkyl, aryl or heterocyclyl (optionally substituted by one or more alkyl, alkoxy, OH, NH2 or mono- or dialkylamino); R2 = 8-30C (especially 12-24C) hydrocarbyl, 1-6C alkyl (optionally substituted by COOH); or 4-20C cycloalkyl, aryl or heterocyclyl (optionally substituted by one or more alkyl, alkoxy, OH, NH2 or mono- or dialkylamino); R3 = PO3H2 or glycosidyl; R3-R5 = H or 1-20C alkyl, cycloalkyl, aryl, aralkyl, cycloalkylalkyl or COR7 (sic); or R4 + R5 = alkylene optionally substituted by one or more alkyl; R6 = H or COR7; and R7 = H, 1-20C aliphatic hydrocarbyl or phenyl-vinyl. N.B. R3 is defined twice in the main claim, but in dependent claims is defined once with R4 and R5 (see "More Specifically").

公开(公告)号：DE59706478D1

公开(公告)日：2002-04-04

申请号：DE59706478

申请日：1997-08-13

Applicant: BASF AG

Inventor： ROSENAU THOMAS ,  HABICHER WOLF-DIETER ,  STREICHER HARALD

IPC: A23L33/15 ,  A61K8/00 ,  A61K8/49 ,  A61K8/67 ,  A23L1/30 ,  A61K31/35 ,  A61K31/375 ,  A61P43/00 ,  A61Q19/00 ,  C07D407/12 ,  C07F9/6558 ,  C08K5/15 ,  C08K5/1545 ,  C09K15/08 ,  C09K15/32

Abstract: Chromanyl-ascorbic acid derivatives of formula (I) are new. R1 = 1-12C aliphatic hydrocarbyl; or 4-12C cycloalkyl, aryl or heterocyclyl (optionally substituted by one or more alkyl, alkoxy, OH, NH2 or mono- or dialkylamino); R2 = 8-30C (especially 12-24C) hydrocarbyl, 1-6C alkyl (optionally substituted by COOH); or 4-20C cycloalkyl, aryl or heterocyclyl (optionally substituted by one or more alkyl, alkoxy, OH, NH2 or mono- or dialkylamino); R3 = PO3H2 or glycosidyl; R3-R5 = H or 1-20C alkyl, cycloalkyl, aryl, aralkyl, cycloalkylalkyl or COR7 (sic); or R4 + R5 = alkylene optionally substituted by one or more alkyl; R6 = H or COR7; and R7 = H, 1-20C aliphatic hydrocarbyl or phenyl-vinyl. N.B. R3 is defined twice in the main claim, but in dependent claims is defined once with R4 and R5 (see "More Specifically").

公开(公告)号：ES2120266T3

公开(公告)日：1998-10-16

申请号：ES96118973

申请日：1996-11-27

Applicant: BASF AG

Inventor： CHEN CHEN-LOUNG ,  ROSENAU THOMAS ,  HABICHER WOLF-DIETER DR

IPC: C07D213/74 ,  C07C209/08 ,  C07C209/60 ,  C07C211/05 ,  C07C211/07 ,  C07C211/08 ,  C07C211/17 ,  C07C211/21 ,  C07C211/27 ,  C07C211/45 ,  C07C211/48 ,  C07C211/58 ,  C07C213/04 ,  C07C215/16 ,  C07C227/08 ,  C07C229/10 ,  C07C229/14 ,  C07C229/18 ,  C07C229/24 ,  C07D311/72 ,  C07K1/06 ,  C07K5/062

Abstract: The present invention relates to a process for preparing protected amines or amino acids. The invention furthermore relates to the use of tocopheryl radicals or radicals derived therefrom as protective groups for amines and amino acids, and to compounds obtained in this process as intermediates and to processes for preparing dipeptides and oligopeptides.

公开(公告)号：AU6613296A

公开(公告)日：1997-02-18

申请号：AU6613296

申请日：1996-07-10

Applicant: BASF AG

Inventor： AUMULLER ALEXANDER ,  TRAUTH HUBERT ,  HABICHER WOLF-DIETER ,  ROSENAU THOMAS

IPC: C07D311/72 ,  C08K5/00 ,  C08K5/15 ,  C09K15/06 ,  C09K15/20 ,  C09K15/22

公开(公告)号：AT170189T

公开(公告)日：1998-09-15

申请号：AT96118973

申请日：1996-11-27

Applicant: BASF AG

Inventor： CHEN CHEN-LOUNG ,  ROSENAU THOMAS ,  HABICHER WOLF-DIETER DR

IPC: C07D213/74 ,  C07C209/08 ,  C07C209/60 ,  C07C211/05 ,  C07C211/07 ,  C07C211/08 ,  C07C211/17 ,  C07C211/21 ,  C07C211/27 ,  C07C211/45 ,  C07C211/48 ,  C07C211/58 ,  C07C213/04 ,  C07C215/16 ,  C07C227/08 ,  C07C229/10 ,  C07C229/14 ,  C07C229/18 ,  C07C229/24 ,  C07D311/72 ,  C07K1/06 ,  C07K5/062

Abstract: The present invention relates to a process for preparing protected amines or amino acids. The invention furthermore relates to the use of tocopheryl radicals or radicals derived therefrom as protective groups for amines and amino acids, and to compounds obtained in this process as intermediates and to processes for preparing dipeptides and oligopeptides.

公开(公告)号：DE19542852A1

公开(公告)日：1997-05-22

申请号：DE19542852

申请日：1995-11-17

Applicant: BASF AG

Inventor： AUMUELLER ALEXANDER DR ,  TRAUTH HUBERT ,  HABICHER WOLF-DIETER DR ,  ROSENAU THOMAS

IPC: C07D311/72 ,  C08K5/15 ,  C09K15/06 ,  C09K15/12 ,  C09K15/32

Abstract: New chroman derivs. are of formula (I), where R = opt. substd. 6-20C aryl or aryloxy, 1-20C alkoxy, CN, COOR , COOH or CONH2; R = 8-30C C-organic residue; R = 1-20C alkyl, opt. with in-chain ether O atoms. Also claimed are; (i) a process for the prodn. of (I); (ii) stabiliser mixts. contg. cpd(s). (I) and an organic phosphite and/or phosphonite and/or amine; and (iii) organic material, esp. plastics, stabilised against the effects of light, oxygen and heat with 0.005-5 wt% (I) or the above stabiliser mixts.

公开(公告)号：DE69600566T2

公开(公告)日：1999-01-07

申请号：DE69600566

申请日：1996-11-27

Applicant: BASF AG

Inventor： CHEN CHEN-LOUNG ,  ROSENAU THOMAS ,  HABICHER WOLF-DIETER DR

IPC: C07D213/74 ,  C07C209/08 ,  C07C209/60 ,  C07C211/05 ,  C07C211/07 ,  C07C211/08 ,  C07C211/17 ,  C07C211/21 ,  C07C211/27 ,  C07C211/45 ,  C07C211/48 ,  C07C211/58 ,  C07C213/04 ,  C07C215/16 ,  C07C227/08 ,  C07C229/10 ,  C07C229/14 ,  C07C229/18 ,  C07C229/24 ,  C07D311/72 ,  C07K1/06 ,  C07K5/062

Abstract: The present invention relates to a process for preparing protected amines or amino acids. The invention furthermore relates to the use of tocopheryl radicals or radicals derived therefrom as protective groups for amines and amino acids, and to compounds obtained in this process as intermediates and to processes for preparing dipeptides and oligopeptides.