公开(公告)号：BG106056A

公开(公告)日：2002-06-28

申请号：BG10605601

申请日：2001-10-26

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  SADOWSKI JEANS ,  KOCK MICHAEL ,  HOEGER THOMAS

IPC: C07D237/32 ,  A61K31/502 ,  A61P1/10 ,  A61P9/00 ,  A61P9/10 ,  A61P13/12 ,  A61P17/02 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/10 ,  A61P25/12 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P35/04 ,  A61P37/00 ,  A61P41/00 ,  A61P43/00 ,  C07D401/12 ,  C07D403/12 ,  A61K31/00

Abstract: The invention relates to the use of phthalazine derivatives as inhibitors of the enzyme poly(ADP-ribose)polymerase or PARP (EC 2.4.2.30) and to their use as inhibitors of PARP-homologous enzymes. These phthalazine derivatives also exhibit, in particular, a selective inhibition of the PARP-homologous enzymes. 19 claims.

公开(公告)号：BG105979A

公开(公告)日：2002-06-28

申请号：BG10597901

申请日：2001-10-04

Applicant: BASF AG

Inventor： ZEICHEL JOHANN-CHRISTIA ,  KLING ANDREAS ,  GENESTE HERVE ,  LANGE UDO ,  LAUTERBACH ARNULF ,  GRAEF CLAUDIA I ,  SUBKOWSKI THOMAS ,  SADOWSKI JEANS ,  HORNBERGER WILFRIED

IPC: C07D239/36 ,  A61K31/505 ,  A61K45/00 ,  A61K45/06 ,  A61P3/14 ,  A61P7/02 ,  A61P9/10 ,  A61P9/12 ,  A61P13/12 ,  A61P17/02 ,  A61P17/06 ,  A61P19/08 ,  A61P19/10 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  C07D239/34 ,  C07D239/60 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/14 ,  C07D417/12 ,  C07D417/14 ,  C07D239/46 ,  C07D403/04

Abstract: The invention relates to novel compounds that bind to integrin receptor ligands. The invention also relates to the production thereof, to their use as integrin receptor ligands and to their use for treating diseases, to pharmaceutical preparations that contain said compounds and to pharmaceutical preparations that contain at least one additional active compound. 33 claims