公开(公告)号：AU7999787A

公开(公告)日：1988-04-28

申请号：AU7999787

申请日：1987-10-21

Applicant: BASF AG

Inventor： KRETZSCHMAR ROLF ,  SCHLICK ERICH ,  EICHELBAUM MICHEL

IPC: A61K31/275 ,  A61K31/277 ,  A61P35/00 ,  A61K31/71 ,  A61K31/72

Abstract: Products containing on the one hand (+)-verapamil, (+)-gallopamil, (+)-devapamil and/or (+)-emopamil, and on the other hand a carcinostatic as combination product for concurrent, separate or sequential administration in cytostatic therapy are described.

公开(公告)号：MX9203405A

公开(公告)日：1992-08-31

申请号：MX9203405

申请日：1992-06-25

Applicant: BASF AG

Inventor： KRETZSCHMAR ROLF ,  SCHLICK ERICH ,  EICHELBAUM MICHAEL

IPC: A61K31/275 ,  A61K31/277 ,  A61P35/00 ,  A61K49/00

Abstract: Products containing on the one hand (+)-verapamil, (+)-gallopamil, (+)-devapamil and/or (+)-emopamil, and on the other hand a carcinostatic as combination product for concurrent, separate or sequential administration in cytostatic therapy are described.

公开(公告)号：MX9203509A

公开(公告)日：1992-08-01

申请号：MX9203509

申请日：1992-06-26

Applicant: BASF AG

Inventor： SCHLICK ERICH ,  KAUFMANN MANFRED ,  RAETH ULRICH

IPC: A61K37/02

公开(公告)号：DE58908571D1

公开(公告)日：1994-12-01

申请号：DE58908571

申请日：1989-08-01

Applicant: BASF AG

Inventor： KEILHAUER GERHARD ,  KOENIG HORST ,  SCHLICK ERICH ,  SEITZ WERNER

IPC: A61K31/275 ,  A61K31/277 ,  A61P3/00 ,  A61P3/14 ,  A61P35/00 ,  C07C255/42 ,  C07C255/43

公开(公告)号：AT113206T

公开(公告)日：1994-11-15

申请号：AT89908428

申请日：1989-08-01

Applicant: BASF AG

Inventor： KEILHAUER GERHARD ,  KOENIG HORST ,  SCHLICK ERICH ,  SEITZ WERNER

IPC: A61K31/275 ,  A61K31/277 ,  A61P3/00 ,  A61P3/14 ,  A61P35/00 ,  C07C255/42 ,  C07C255/43

公开(公告)号：ZA877901B

公开(公告)日：1989-06-28

申请号：ZA877901

申请日：1987-10-21

Applicant: BASF AG

Inventor： KRETZSCHMAR ROLF ,  ROLF KRETZSCHMAR ,  SCHLICK ERICH ,  ERICH SCHLICK ,  EICHELBAUM MICHEL ,  MICHEL EICHELBAUM

IPC: A61K31/275 ,  A61K31/277 ,  A61P35/00 ,  A61K

Abstract: Products containing on the one hand (+)-verapamil, (+)-gallopamil, (+)-devapamil and/or (+)-emopamil, and on the other hand a carcinostatic as combination product for concurrent, separate or sequential administration in cytostatic therapy are described.

公开(公告)号：AU604064B2

公开(公告)日：1990-12-06

申请号：AU7999787

申请日：1987-10-21

Applicant: BASF AG

Inventor： KRETZSCHMAR ROLF ,  SCHLICK ERICH ,  EICHELBAUM MICHEL

IPC: A61K31/275 ,  A61K31/277 ,  A61P35/00 ,  A61K31/71 ,  A61K31/72

Abstract: Products containing on the one hand (+)-verapamil, (+)-gallopamil, (+)-devapamil and/or (+)-emopamil, and on the other hand a carcinostatic as combination product for concurrent, separate or sequential administration in cytostatic therapy are described.

公开(公告)号：AP102A

公开(公告)日：1990-10-23

申请号：AP8900134

申请日：1989-08-04

Applicant: BASF AG

Inventor： KEILHAVER GERHARD ,  KOENIG HORST ,  SCHLICK ERICH ,  SEOTZ WERNER

IPC: A61K31/275 ,  A61K31/277 ,  A61P3/00 ,  A61P3/14 ,  A61P35/00 ,  C07C255/42 ,  C07C255/43

Abstract: Racemic and optionally active substituted phenylacetonitriles of the formula 1 where r1, r2 and r3 are hydrogen, halogen, c1-4 alkyl, c1-4-alkoxy trifluoromethyl, or two adjacent substituents. R1and r2 or r3 to another form -ch2 -ch -ch2 -ch2 or -ch=ch-ch=ch, r4 is alkyl or cycloalkyk having up to 15 carbon atoms or phenyl, r5 is hydrogen or c1-4-alkyl, are each 2,3 or 4 and up m and n is alkyl having up to 20 carbon atoms, c1-5-cycloalkyl or the group where r7, r8, and r9 are hydrogen, halogen, c1-c4, -alkyl, c1-c4-alkoxy, trifluoromethyl, or two adjacent substituents r2 and r8 or r9 together form -ch2-ch2-ch2- or -ch=ch-ch=ch;as well as the salts thereof with physiologically tolerated acids which can be used to prepare drugs to break resistance to antimalarials such as chloroquine, hydrochloroquinine, uinine, pyrimethamine, mefloquine and primaquine in malaria patients.

公开(公告)号：AU3122189A

公开(公告)日：1989-09-14

申请号：AU3122189

申请日：1989-03-10

Applicant: BASF AG

Inventor： DAUM LOTHAR ,  SCHLICK ERICH ,  HERR DIETER ,  GEISS KARL-HEINZ ,  DOERPER THOMAS

IPC: C12N9/99 ,  A61K31/505 ,  A61K31/52 ,  A61K31/715 ,  A61K38/00 ,  A61K38/19 ,  A61K38/21 ,  A61K39/395 ,  A61K45/06 ,  A61P31/12 ,  A61P37/00 ,  A61P43/00 ,  A61K31/725

公开(公告)号：ZA8707901B

公开(公告)日：1989-06-28

申请号：ZA8707901

申请日：1987-10-21

Applicant: BASF AG

Inventor： KRETZSCHMAR ROLF ,  ROLF KRETZSCHMAR ,  SCHLICK ERICH ,  ERICH SCHLICK ,  EICHELBAUM MICHEL ,  MICHEL EICHELBAUM

IPC: A61K31/275 ,  A61K31/277 ,  A61P35/00 ,  A61K

CPC classification number: A61K31/275