公开(公告)号：AT273947T

公开(公告)日：2004-09-15

申请号：AT00902598

申请日：2000-01-15

Applicant: BASF AG

Inventor： THYES MARCO ,  FALKENBERG WOLFGANG ,  SCHNEIDER ULRICH

IPC: B01D11/04 ,  A61K31/215 ,  A61P13/04 ,  A61P13/06 ,  C07C227/38 ,  C07C227/40 ,  C07C229/46 ,  C07C229/48

Abstract: A process for reducing the content of ethyl 3-dimethylamino-2-phenylpropionate in a solution, contaminated therewith, of ethyl 2-dimethylamino-1-phenyl-3-cyclohexene-1-carboxylate in a water-immiscible solvent, which comprises adding from 0.5 to 2.0 equivalents of a carboxylic acid per mole of ethyl 2-dimethylamino-1-phenyl-3-cyclohexene-1-carboxylate to this solution, and stirring this mixture at a temperature of from 50° C. to 100° C., is described.

公开(公告)号：DE59908757D1

公开(公告)日：2004-04-08

申请号：DE59908757

申请日：1999-07-28

Applicant: BASF AG

Inventor： FALKENBERG WOLFGANG ,  THYES MARCO ,  WENZ CONNY ,  SCHNEIDER ULRICH

IPC: C07B61/00 ,  C07C67/343 ,  C07C69/618

Abstract: A process for preparing ethyl atropate by reacting ethyl phenylacetate with paraformaldehyde in the presence of a base is described and entails employing as ethyl phenylacetate a product which contains not more than 0.03% of the corresponding methyl phenylacetate, and carrying out the reaction in N-methyl-pyrrolidone or N,N-dimethylformamide.

公开(公告)号：AU766196B2

公开(公告)日：2003-10-09

申请号：AU2437600

申请日：2000-01-15

Applicant: BASF AG

Inventor： THYES MARCO ,  FALKENBERG WOLFGANG ,  SCHNEIDER ULRICH

IPC: B01D11/04 ,  A61K31/215 ,  A61P13/04 ,  A61P13/06 ,  C07C227/38 ,  C07C227/40 ,  C07C229/46 ,  C07C229/48

Abstract: A process for reducing the content of ethyl 3-dimethylamino-2-phenylpropionate in a solution, contaminated therewith, of ethyl 2-dimethylamino-1-phenyl-3-cyclohexene-1-carboxylate in a water-immiscible solvent, which comprises adding from 0.5 to 2.0 equivalents of a carboxylic acid per mole of ethyl 2-dimethylamino-1-phenyl-3-cyclohexene-1-carboxylate to this solution, and stirring this mixture at a temperature of from 50° C. to 100° C., is described.

公开(公告)号：DE50007472D1

公开(公告)日：2004-09-23

申请号：DE50007472

申请日：2000-01-15

Applicant: BASF AG

Inventor： THYES MARCO ,  FALKENBERG WOLFGANG ,  SCHNEIDER ULRICH

IPC: B01D11/04 ,  A61K31/215 ,  A61P13/04 ,  A61P13/06 ,  C07C227/38 ,  C07C227/40 ,  C07C229/46 ,  C07C229/48

Abstract: A process for reducing the content of ethyl 3-dimethylamino-2-phenylpropionate in a solution, contaminated therewith, of ethyl 2-dimethylamino-1-phenyl-3-cyclohexene-1-carboxylate in a water-immiscible solvent, which comprises adding from 0.5 to 2.0 equivalents of a carboxylic acid per mole of ethyl 2-dimethylamino-1-phenyl-3-cyclohexene-1-carboxylate to this solution, and stirring this mixture at a temperature of from 50° C. to 100° C., is described.

公开(公告)号：PT1104397E

公开(公告)日：2004-05-31

申请号：PT99940069

申请日：1999-07-28

Applicant: BASF AG

Inventor： THYES MARCO ,  FALKENBERG WOLFGANG ,  WENZ CONNY ,  SCHNEIDER ULRICH

IPC: C07B61/00 ,  C07C67/343 ,  C07C69/618

Abstract: A process for preparing ethyl atropate by reacting ethyl phenylacetate with paraformaldehyde in the presence of a base is described and entails employing as ethyl phenylacetate a product which contains not more than 0.03% of the corresponding methyl phenylacetate, and carrying out the reaction in N-methyl-pyrrolidone or N,N-dimethylformamide.

公开(公告)号：AT260883T

公开(公告)日：2004-03-15

申请号：AT99940069

申请日：1999-07-28

Applicant: BASF AG

Inventor： FALKENBERG WOLFGANG ,  THYES MARCO ,  WENZ CONNY ,  SCHNEIDER ULRICH

IPC: C07B61/00 ,  C07C67/343 ,  C07C69/618

Abstract: A process for preparing ethyl atropate by reacting ethyl phenylacetate with paraformaldehyde in the presence of a base is described and entails employing as ethyl phenylacetate a product which contains not more than 0.03% of the corresponding methyl phenylacetate, and carrying out the reaction in N-methyl-pyrrolidone or N,N-dimethylformamide.

公开(公告)号：HK1050181A1

公开(公告)日：2003-06-13

申请号：HK03101980

申请日：2003-03-18

Applicant: BASF AG

Inventor： FALKENBERG MARCO THYES WOLFGAN ,  SCHNEIDER ULRICH

IPC: B01D11/04 ,  A61K31/215 ,  A61P13/04 ,  A61P13/06 ,  C07C227/38 ,  C07C227/40 ,  C07C229/46 ,  C07C229/48 ,  C07C

Abstract: A process for reducing the content of ethyl 3-dimethylamino-2-phenylpropionate in a solution, contaminated therewith, of ethyl 2-dimethylamino-1-phenyl-3-cyclohexene-1-carboxylate in a water-immiscible solvent, which comprises adding from 0.5 to 2.0 equivalents of a carboxylic acid per mole of ethyl 2-dimethylamino-1-phenyl-3-cyclohexene-1-carboxylate to this solution, and stirring this mixture at a temperature of from 50° C. to 100° C., is described.

公开(公告)号：CZ20012602A3

公开(公告)日：2003-01-15

申请号：CZ20012602

申请日：2000-01-15

Applicant: BASF AG

Inventor： THYES MARCO ,  FALKENBERG WOLFGANG ,  SCHNEIDER ULRICH

IPC: B01D11/04 ,  A61K31/215 ,  A61P13/04 ,  A61P13/06 ,  C07C227/38 ,  C07C227/40 ,  C07C229/46 ,  C07C229/48

Abstract: A process for reducing the content of ethyl 3-dimethylamino-2-phenylpropionate in a solution, contaminated therewith, of ethyl 2-dimethylamino-1-phenyl-3-cyclohexene-1-carboxylate in a water-immiscible solvent, which comprises adding from 0.5 to 2.0 equivalents of a carboxylic acid per mole of ethyl 2-dimethylamino-1-phenyl-3-cyclohexene-1-carboxylate to this solution, and stirring this mixture at a temperature of from 50° C. to 100° C., is described.

公开(公告)号：ES2226777T3

公开(公告)日：2005-04-01

申请号：ES00902598

申请日：2000-01-15

Applicant: BASF AG

Inventor： THYES MARCO ,  FALKENBERG WOLFGANG ,  SCHNEIDER ULRICH

IPC: B01D11/04 ,  A61K31/215 ,  A61P13/04 ,  A61P13/06 ,  C07C227/38 ,  C07C227/40 ,  C07C229/46 ,  C07C229/48

Abstract: Procedimiento para la reducción del contenido en 3-dimetilamino-2-fenilpropionato de etilo en una solución, impurificada con el mismo, del 2- dimetilamino-1-fenil-3-ciclohexen-1-carboxilato de etilo en un disolvente no miscible con agua, caracterizado porque ésta solución se combina con 0, 75 hasta 2, 0 equivalentes de un ácido carboxílico por mol de 2-dimetilamino-1-fenil-3-ciclohexen-1-carboxilato de etilo y ésta mezcla se agita durante un tiempo comprendido en el intervalo desde 0, 5 hasta 2 horas a una temperatura de 50ºC hasta 100ºC.

公开(公告)号：ES2217795T3

公开(公告)日：2004-11-01

申请号：ES99940069

申请日：1999-07-28

Applicant: BASF AG

Inventor： FALKENBERG WOLFGANG ,  THYES MARCO ,  WENZ CONNY ,  SCHNEIDER ULRICH

IPC: C07B61/00 ,  C07C67/343 ,  C07C69/618

Abstract: A process for preparing ethyl atropate by reacting ethyl phenylacetate with paraformaldehyde in the presence of a base is described and entails employing as ethyl phenylacetate a product which contains not more than 0.03% of the corresponding methyl phenylacetate, and carrying out the reaction in N-methyl-pyrrolidone or N,N-dimethylformamide.