公开(公告)号：JPH1072400A

公开(公告)日：1998-03-17

申请号：JP16085497

申请日：1997-06-18

Applicant: BASF AG

Inventor： BREITENBACH JOERG DR ,  ROSENBERG JOERG DR ,  NEUMANN JOERG DR ,  ZEIDLER JUERGEN DR ,  SIMON DIRK DR ,  DIENER RALPH DR

IPC: A61K31/19 ,  A61K9/16 ,  A61K31/00 ,  B01J19/00 ,  C07C51/41 ,  C07C57/30 ,  C07C229/26

Abstract: PROBLEM TO BE SOLVED: To provide a method for producing a salt of a pharmaceutically active material without lowering a quality, especially fluidity by reacting an acid with a base in a molten liquid so that the acid may be reacted with at least stoichiometric amount of the base in an extruder. SOLUTION: The objective salt of a pharmaceutically active material is obtained by reacting (A) a carboxylic acid with (B) a base in a molten liquid so that the acid may be reacted with at least stoichiometric amount of the base in an extruder. The method is preferably used for production of a salt of a derivative of salicylic acid, e.g. acetylasalicylic acid, or an arylcarboxylic acid, e.g. diclofenac, tolmetin or zomepirac. A basic α-aminocarboxylic acid, especially ricin, a base of an alkali(ne earth) metal, etc., are preferable as the component B. The amount of the above base is at least stoichiometric amount, preferably 1-40mol% excess based on the acid.

公开(公告)号：ES2227636T3

公开(公告)日：2005-04-01

申请号：ES97109455

申请日：1997-06-11

Applicant: BASF AG

Inventor： BREITENBACH JORG DR ,  ROSENBERG JOERG DR ,  NEUMANN JORG DR ,  ZEIDLER JURGEN DR ,  SIMON DIRK DR ,  DIENER RALPH DR

IPC: A61K31/19 ,  A61K9/16 ,  A61K31/00 ,  B01J19/00 ,  C07C51/41 ,  C07C57/30 ,  C07C229/26

Abstract: PROCEDIMIENTO PARA LA FABRICACION DE SALES DE SUSTANCIAS ACTIVAS FARMACEUTICAS QUE LLEVAN GRUPOS ACIDOS MEDIANTE TRANSFORMACION DE LOS ACIDOS CARBONICOS CON UNA BASE EN LA FUSION, TRANSFORMANDO LOS ACIDOS CON UNA CANTIDAD ESTEQUIMETRICA COMO MINIMO DE UNA BASE EN LA EXTRUSIONADORA.

公开(公告)号：DE19624607A1

公开(公告)日：1998-01-02

申请号：DE19624607

申请日：1996-06-20

Applicant: BASF AG

Inventor： BREITENBACH JOERG DR ,  ROSENBERG JOERG DR ,  NEUMANN JOERG DR ,  ZEIDLER JUERGEN DR ,  SIMON DIRK DR ,  DIENER RALPH DR

IPC: A61K31/19 ,  A61K9/16 ,  A61K31/00 ,  B01J19/00 ,  C07C51/41 ,  C07C57/30 ,  C07C229/26 ,  A61K31/195

Abstract: Preparation of a salt of a pharmaceutically active carboxylic acid compound comprises reacting the acid in an extruder with ≥ 1 stoichiometric equivalent of a base in melt form.

公开(公告)号：EP0813904A2

公开(公告)日：1997-12-29

申请号：EP97109455

申请日：1997-06-11

Applicant: BASF AG

Inventor： BREITENBACH JOERG DR ,  ROSENBERG JOERG DR ,  NEUMANN JOERG DR ,  ZEIDLER JUERGEN DR ,  SIMON DIRK DR ,  DIENER RALPH DR

IPC: A61K31/19 ,  A61K9/16 ,  C07C51/41 ,  C07C57/30 ,  C07C229/26 ,  B01J19/00 ,  A61K31/00

CPC classification number: A61K9/1688 ,  C07C51/412 ,  C07C57/30

Abstract: Verfahren zur Herstellung von Salzen von Säuregruppen tragenden pharmazeutischen Wirkstoffen durch Umsetzung der Carbonsäuren mit einer Base in der Schmelze, indem man die Säuren mit einer mindestens stöchiometrischen Menge einer Base im Extruder umsetzt.

Abstract translation: 药学活性羧酸化合物的盐的制备包括在挤出机中与≥1以熔融形式的碱的化学计量等价物反应的酸。