中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

6 records (took 0.02 seconds)

    PRODUCTION OF SLAT OF PHARMACEUTICALLY ACTIVE MATERIAL
    1.
    发明专利
    PRODUCTION OF SLAT OF PHARMACEUTICALLY ACTIVE MATERIAL 失效

    公开(公告)号：JPH1072400A

    公开(公告)日：1998-03-17

    申请号：JP16085497

    申请日：1997-06-18

    Applicant: BASF AG

    Inventor： BREITENBACH JOERG DR ,  ROSENBERG JOERG DR ,  NEUMANN JOERG DR ,  ZEIDLER JUERGEN DR ,  SIMON DIRK DR ,  DIENER RALPH DR

    IPC: A61K31/19 ,  A61K9/16 ,  A61K31/00 ,  B01J19/00 ,  C07C51/41 ,  C07C57/30 ,  C07C229/26

    Abstract: PROBLEM TO BE SOLVED: To provide a method for producing a salt of a pharmaceutically active material without lowering a quality, especially fluidity by reacting an acid with a base in a molten liquid so that the acid may be reacted with at least stoichiometric amount of the base in an extruder. SOLUTION: The objective salt of a pharmaceutically active material is obtained by reacting (A) a carboxylic acid with (B) a base in a molten liquid so that the acid may be reacted with at least stoichiometric amount of the base in an extruder. The method is preferably used for production of a salt of a derivative of salicylic acid, e.g. acetylasalicylic acid, or an arylcarboxylic acid, e.g. diclofenac, tolmetin or zomepirac. A basic α-aminocarboxylic acid, especially ricin, a base of an alkali(ne earth) metal, etc., are preferable as the component B. The amount of the above base is at least stoichiometric amount, preferably 1-40mol% excess based on the acid.

    MANUFACTURE OF AT LEAST TWO-PHASE SOLID BLENDED MEDICINE SHAPE AND THIS BLENDED MEDICINE SHAPE
    2.
    发明专利
    MANUFACTURE OF AT LEAST TWO-PHASE SOLID BLENDED MEDICINE SHAPE AND THIS BLENDED MEDICINE SHAPE 失效

    公开(公告)号：JPH10314279A

    公开(公告)日：1998-12-02

    申请号：JP6095798

    申请日：1998-03-12

    Applicant: BASF AG

    Inventor： ZEIDLER JUERGEN DR ,  ROSENBERG JOERG DR ,  BREITENBACH JOERG DR ,  KLEINKE ANDREAS DR ,  MAIER WERNER

    IPC: A61J3/10 ,  A61K9/20 ,  A61K47/26 ,  A61K47/30 ,  B30B11/16

    Abstract: PROBLEM TO BE SOLVED: To manufacture a solid blended medicine shape in a large variation width by housing a solid preparation in a plastic material, and containing a single active substance in melt and/or the preparation when a medicine shape is molded from the melt composed of a high molecular weight binding agent. SOLUTION: Melt composed of a high molecular weight binding agent (for example, alkyl cellulose, hydroxyalkyl cellulose or the like) and an-active substance is molded. When this is molded, a single solid preparation containing the active substance is put in a plastic material. In a molding process, metal mold rollers 1 and 2 are rotated in the opposite direction, and a strand 3 from an extruder is composed of an active substance containing high molecular weight binding agent, and is sent into the two rollers 1 and 2 in the arrow direction. At the same time, melt composed of an active substance containing high molecular weight binding agent B is sent into a recess of the roller 1 from a supply device 4. Since the roller 1 is cooled, the melt immediately coagulates. A tablet is punched from the strand 3 by opposite directional rotation of the rollers 1 and 2.

Patent Agency Ranking