公开(公告)号：DE50100268D1

公开(公告)日：2003-07-03

申请号：DE50100268

申请日：2001-03-27

Applicant: BASF AG

Inventor： FALKE DR ,  HENDREICH REGINA ,  STUERMER DR ,  FRIEDRICH DR

IPC: C08G18/00 ,  C08G18/40 ,  C08G18/48 ,  C08G18/64 ,  C08J9/00 ,  C08J9/10 ,  C08J9/32 ,  C12N11/08 ,  C12P7/62 ,  C12P41/00

Abstract: Production of products comprising biologically active substances covalently bound to polyurethane foam comprises generating isocyanate (NCO) groups and optionally other reactive groups on the surface of the foam and covalently attaching biologically active substances to these groups.

公开(公告)号：DE59902329D1

公开(公告)日：2002-09-19

申请号：DE59902329

申请日：1999-12-03

Applicant: BASF AG

Inventor： STUERMER DR ,  BALDENIUS DR

IPC: B65D33/28 ,  C07D309/30 ,  C07D311/66 ,  C07D311/70 ,  C07D407/04

Abstract: Preparation of substituted chroman derivatives in multi-stage process from acrolein-aldehyde starting material via new intermediates. Preparation of substituted chroman derivatives of formula (VII) comprises: (a) reacting an acrolein-aldehyde of formula (I) with an acrylonitrile-, acrolein-, acrolein-acetal-, allyl-alcohol- or allyl ether of formula (II) to give the corresponding 3,4-dihydro-2H-pyran of formula (III); (b) treating (III) with an acid to give the corresponding 5-oxo derivative of formula (IV); (c) reacting this with a substituted vinyl-ketone of formula (V) to give a chromen-6-one of formula (VI); and (d) dehydrating to give (VII). X = CN, COOR3, CHO, CH2OR7 or CH(OR8)2; R1 = 1-4C alkyl, 6-18C aryl, 7-18C aralkyl, optionally halogenated 1-4C acyl or an acid labile hydroxy protecting group; R2 = 1-23C alkyl, 2-23C alkenyl, 6-18C aryl or 7-18C aralkyl; R3 = H, 1-4C alkyl, 1-4C haloalkyl, 1-4C hydroxyalkyl or 1-4C aminoalkyl; R4-R6 = H or 1-4C alkyl; R7 = H or 1-4C alkyl; R8 = 1-4C alkyl; or R8+R8 = 2-6C alkenyl optionally branched and optionally substituted by 1-2 carboxyl, cyclohexyl or phenyl. Independent claims are included for: (1) pyran derivatives (III) as new; (2) preparation of (III) using step (a) as above; (3) tetrahydropyran derivatives (IV); (4) preparation of (IV) using steps (a) and (b) as above; (5) chromen-6-one derivatives (VI); (6) preparation of (VI) using step (c) as above.

公开(公告)号：DE50005399D1

公开(公告)日：2004-04-01

申请号：DE50005399

申请日：2000-09-21

Applicant: BASF AG

Inventor： SCHEIN DR ,  BALDENIUS DR ,  SIEGEL DR ,  STUERMER DR ,  RUFF DR ,  JAEDICKE DR

IPC: C07B61/00 ,  C07C45/46 ,  C07C49/825 ,  C07C67/42 ,  C07C69/017 ,  C07C69/16

Abstract: Preparation of monoacetylated hydroquinone compound comprises reacting a dicetylphenol compound with peroxo compounds optionally using an acid in one reaction step. Preparation of monoacetylated hydroquinone compound of formula (I) comprises reacting a dicetylphenol compound of formula (II) with peroxo compounds optionally using an acid. R1-R3 = H or Me. Independent claims are included for: (1) preparation of (II) by reacting phenol compounds of formula (III) with an acetylation agent using an acid catalyst; (2) preparation of monoacetylated hydroquinone compounds (I) by reacting (III) with an acetylation agent using an acid catalyst to give (II) and further reacting with peroxo compounds, optionally in the presence of an acid; and (3) compounds of formula (Ia)-(Ie).

公开(公告)号：DE50105413D1

公开(公告)日：2005-03-31

申请号：DE50105413

申请日：2001-11-30

Applicant: BASF AG

Inventor： FUNKE DR ,  LIANG DR ,  KRAMER DR ,  STUERMER DR ,  HOEHN DR

IPC: C07B55/00 ,  C07B61/00 ,  C07C209/68 ,  C07C209/88 ,  C07C211/03 ,  C07C209/00 ,  C07C213/00 ,  C07C213/02 ,  C07C217/08

Abstract: Racemization of optically active amines (I) comprises reaction at elevated temperature in the presence of hydrogen and a supported copper and zinc oxide catalyst. Racemization of optically active amines of formula (I) comprises reaction at elevated temperature in the presence of hydrogen and a supported copper and zinc oxide catalyst. R , R = alkyl, cycloalkyl, aralkyl, aryl, heteroaryl or heterocyclyl; all optionally substituted by alkyl, cycloalkyl, alkoxy, aryloxy, amino, alkylamino or dialkylamino, provided that R and R are different; and R = H or a group as defined for R and R .

公开(公告)号：DE59609845D1

公开(公告)日：2002-12-12

申请号：DE59609845

申请日：1996-05-08

Applicant: BASF AG

Inventor： STUERMER DR ,  LAUPICHLER DR ,  KNOCHEL PROF DR ,  LANGER FALK

IPC: C07B53/00 ,  C07C45/50 ,  C07C209/68 ,  C07F9/50 ,  C07F15/00

Abstract: Optically active phosphines of formula XnPRm (I) and Y(PXnRm)2 (II) and their transition metal complexes of formula (III) and (IV) are new. X = an optically active terpene residue; R = opt. substd. phenyl; Y = 1-10C bridging gp.; n = 1-3, m = 0-2 and n+m = 3; r = 1-2, s = 0-1 and r+s = 2; D = 1 equiv. of an noncoordinated anion; L = an organic ligand; M = a transition metal; p, q = 0-4.

公开(公告)号：DE59803583D1

公开(公告)日：2002-05-16

申请号：DE59803583

申请日：1998-05-29

Applicant: BASF AG ,  MAX PLANCK GESELLSCHAFT

Inventor： STUERMER DR ,  BOERNER DR ,  HOLZ DR ,  VOSS GUDRUN

IPC: B01J31/22 ,  B01J31/24 ,  C07B53/00 ,  C07C45/50 ,  C07F9/6568 ,  C07F15/00

Abstract: Phospholane and diphospholane compounds of formula (I) are new. R , R = independently 1-6C alkyl, aryl or alkylaryl (R may also be H); Either A has the same meanings as R , or is a group of formula (i), where B is a 1-5C bridging group. Also claimed are metal complexes of (I) whose metal atom is selected from Rh, Ru, Ir, Pd, Pt or Ni. Also claimed is a method for asymmetric hydrogenation of a starting compound, which comprises reacting it with hydrogen in the presence of the metal complex at 1 - 2 bar.