公开(公告)号：BR9711724A

公开(公告)日：1999-08-24

申请号：BR9711724

申请日：1997-08-22

Applicant: BASF AG

Inventor： STEINER GERD ,  LUBISCH WILFRIED ,  BACH ALFRED ,  EMLING FRANZ ,  WICKE KARSTEN ,  TESCHENDORF HANS JURGEN ,  BEHL BERTHOLD ,  CHEETHAM SHARON ,  KERRIGAN FRANK

IPC: A61K31/435 ,  A61K31/519 ,  A61P25/24 ,  A61P43/00 ,  C07D211/00 ,  C07D239/00 ,  C07D333/00 ,  C07D495/14

Abstract: A 3-substituted 3,4,5,6,7,8-hexahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine compound of formula IwhereinR1 is hydrogen, C1-C4-alkyl, acetyl or benzoyl, optionally substituted phenyl-C1-C4-alkyl, naphthyl-C1-C3-alkyl, phenyl-C2-C3-alkanone or a phenylcarbamoyl-C2-alkyl,R2 is optionally substituted phenyl, pyridyl, pyrimidyl or pyrazinyl, or an optionally substituted bicyclus wherein one of the two fused rings is a phenyl, a pyridyl, a pyrimidyl or a pyrazinyl ring,A is NH or oxygen,B is hydrogen or methyl,C is hydrogen, methyl or hydroxyl,X is nitrogen,Y is CH2, CH2-C2, CH2-C2-CH2 or CH2-CH,Z is nitrogen, C or CH, and the linkage between Y and Z is a single or a double bond, andn is 2, 3 or 4,or a physiologically tolerated salt thereof, and compositions comprising them and their use as antagonists of 5HT1B and 5HT1A and for the treatment of depression and related disorders.

公开(公告)号：ID27964A

公开(公告)日：2001-05-03

申请号：ID20010348

申请日：1999-07-20

Applicant: BASF AG

Inventor： STEINER GERD ,  HOGER THOMAS ,  UNGER LILIANE ,  TESCHENDORF HANS JURGEN ,  JUCHELKA FRIEDER

IPC: A61K31/4184 ,  A61P25/20 ,  A61P25/24 ,  A61P25/30 ,  C07D403/06

Abstract: The invention relates to compounds of formula (1), wherein R , R and R have the meaning cited in the description. The novel substances are suitable for use in disease control.