公开(公告)号：ZA8103966B

公开(公告)日：1982-07-28

申请号：ZA8103966

申请日：1981-06-12

Applicant: BASF AG

Inventor： THYES M ,  FRANKE A ,  KOENIG H ,  LENKE D ,  LEHMANN H ,  GRIES J

IPC: A61K31/50 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  A61K ,  C07C

CPC classification number: C07D237/04

公开(公告)号：DK281482A

公开(公告)日：1982-12-25

申请号：DK281482

申请日：1982-06-23

Applicant: BASF AG

Inventor： ROSSY P A ,  THYES M ,  FRANKE A ,  KOENIG H ,  LEHMANN H D ,  LENKE D

IPC: A61K31/50 ,  A61K31/55 ,  A61P7/02 ,  A61P9/12 ,  C07D209/34 ,  C07D215/22 ,  C07D215/227 ,  C07D223/16 ,  C07D401/04 ,  C07D403/04 ,  C07D

Abstract: 2-Aryl-3,4-diazabicyclo[4.n.O]alk-2-en-5-ones of the formula I I where m and n are identical or different and each is 1, 2 or 3, and R, R1 and R2 are identical or different and each is hydrogen or alkyl of 1 to 6 C atoms, said compounds are useful for treating high blood pressure and thrombo-embolic disorders.

公开(公告)号：ZA813967B

公开(公告)日：1982-07-28

申请号：ZA813967

申请日：1981-06-12

Applicant: BASF AG

Inventor： THYES M ,  KOENIG H ,  LENKE D ,  LEHMANN H ,  GRIES J

IPC: A61K31/50 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  A61K ,  C07C

Abstract: Novel 6-(p-acylaminophenyl)-4,5-dihydro-3(2H)-pyridazinones, whose acyl radical is derived from a cycloalkylcarboxylic acid, processes for their preparation, pharmaceutical formulations containing these compounds, and their use as drugs in thrombo-embolic disorders and as anti-hypertensives.

公开(公告)号：ZA796789B

公开(公告)日：1980-12-31

申请号：ZA796789

申请日：1979-12-14

Applicant: BASF AG

Inventor： GRIES J ,  THYES M ,  LENKE D ,  LEHMANN H ,  KUNZE J

IPC: A61K31/395 ,  A61K31/502 ,  A61K31/50 ,  A61P7/02 ,  A61P9/12 ,  C07C62/38 ,  C07C205/56 ,  C07D231/54 ,  C07D237/26 ,  A61K ,  C07C

Abstract: 2-Aryl-3,4-diaza-bicyclo-[4.1.0]hept-2-en-5-ones, substituted in the phenyl ring, of the general formula their preparation, and therapeutic agents, containing these compounds, which may be used for the treatment of hypertension or of thrombo-embolic disorders.

公开(公告)号：ZA813966B

公开(公告)日：1982-07-28

申请号：ZA813966

申请日：1981-06-12

Applicant: BASF AG

Inventor： THYES M ,  FRANKE A ,  KOENIG H ,  LENKE D ,  LEHMANN H ,  GRIES J

IPC: A61K31/50 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  A61K ,  C07C

公开(公告)号：ZA8103967B

公开(公告)日：1982-07-28

申请号：ZA8103967

申请日：1981-06-12

Applicant: BASF AG

Inventor： THYES M ,  KOENIG H ,  LENKE D ,  LEHMANN H ,  GRIES J

IPC: A61K31/50 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  A61K ,  C07C

CPC classification number: C07D237/04

公开(公告)号：DK532579A

公开(公告)日：1980-06-16

申请号：DK532579

申请日：1979-12-14

Applicant: BASF AG

Inventor： THYES M ,  GRIES J ,  LEHMANN H D ,  LENKE D ,  KUNZE J

IPC: A61K31/50 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  C07D

公开(公告)号：ZA783464B

公开(公告)日：1979-07-25

申请号：ZA783464

申请日：1978-06-16

Applicant: BASF AG

Inventor： KOENIG H ,  THYES M ,  LEHMANN H ,  LEBKUECHER R ,  KUNZE J ,  GRIES J ,  LENKE D

IPC: A61K31/50 ,  C07D237/00 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  C07D

Abstract: 6-(p-Acylaminophenyl)-4,5-dihydropyridaz-3-ones of the formula I I where R1 is hydrogen or alkyl of 1 to 3 carbon atoms and R2, if R1 is hydrogen, is halogen-substituted alkyl of 3 to 6 carbon atoms or beta -haloethyl or, if R1 is alkyl of 1 to 3 carbon atoms, is halogen-substituted alkyl of 1 to 6 carbon atoms, their manufacture, and therapeutic agents which contain, as the active ingredient, a compound of the formula I, where R2 may also be halomethyl or alpha -haloethyl if R1 is hydrogen. These compounds may be used as anti-hypertensive agents and for the prophylaxis and therapy of thromboembolic disorders.

公开(公告)号：DK257481A

公开(公告)日：1981-12-14

申请号：DK257481

申请日：1981-06-12

Applicant: BASF AG

Inventor： THYES M ,  FRANKE A ,  KOENIG H ,  LENKE D ,  LEHMANN H D ,  GRIES J

IPC: A61K31/50 ,  C07D237/04 ,  C07D

Abstract: Novel 6-phenyl-4,5-dihydro-3(2H)-pyridazinones which are substituted in the p-position of the phenyl ring by a carbamate or thiocarbamate group, processes for their preparation, pharmaceutical formulations containing these compounds, and their use as drugs in thrombo-embolic disorders, and as anti-hypertensives.

公开(公告)号：DK257381A

公开(公告)日：1981-12-14

申请号：DK257381

申请日：1981-06-12

Applicant: BASF AG

Inventor： THYES M ,  KOENIG H ,  LENKE D ,  LEHMANN H D ,  GRIES J

IPC: A61K31/50 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  C07D

Abstract: Novel 6-(p-acylaminophenyl)-4,5-dihydro-3(2H)-pyridazinones, whose acyl radical is derived from a cycloalkylcarboxylic acid, processes for their preparation, pharmaceutical formulations containing these compounds, and their use as drugs in thrombo-embolic disorders and as anti-hypertensives.