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    PROCESS FOR OBTAINING HEXAHYDRO-1,4-OXAZEPINE
    2.
    发明专利
    PROCESS FOR OBTAINING HEXAHYDRO-1,4-OXAZEPINE 未知

    公开(公告)号：YU6680A

    公开(公告)日：1983-02-28

    申请号：YU6680

    申请日：1980-01-11

    Applicant: BASF AG

    Inventor： TREIBER H ,  LENKE D ,  WORSTMANN W

    IPC: A61K31/55 ,  A61K31/553 ,  A61P25/04 ,  C07D267/10 ,  C07D267/22 ,  A61K31/33

    Abstract: Novel hexahydro-1,4-oxazepines of the general formula I I where R1 is hydrogen, or alkyl or acyl each of 1 to 4 carbon atoms, R2 is alkyl of 1 to 4 carbon atoms and R3 and R4 are identical or different and each is hydrogen or methyl, and their salts with physiologically acceptable acids, processes for their preparation, drugs which contain these compounds, and their use in therapy. The compounds may be used for the pharmacotherapy of pain of various geneses.

    AMINO DERIVATIVES OF 3-ALKYL-5-(2-HYDROXYSTYRYL)-ISOXAZOLES
    7.
    发明专利
    AMINO DERIVATIVES OF 3-ALKYL-5-(2-HYDROXYSTYRYL)-ISOXAZOLES 未知

    公开(公告)号：ZA792025B

    公开(公告)日：1980-06-25

    申请号：ZA792025

    申请日：1979-04-27

    Applicant: BASF AG

    Inventor： THIEME P ,  FRANKE A ,  THEOBALD H ,  GRIES J ,  FRICKEL F ,  LENKE D

    IPC: A61K31/41 ,  A61K31/42 ,  A61P9/00 ,  A61P9/06 ,  A61P9/12 ,  A61P25/02 ,  C07D261/08 ,  C07D ,  A61K

    Abstract: Alkylamino-propanol derivatives of 3-alkyl-5-(2-hydroxystyryl)-isoxazole, of the general formula where R is hydrogen, alkyl of 1 to 8 carbon atoms, which is unsubstituted or substituted by hydroxyl, alkoxy of 1 to 3 carbon atoms or cycloalkyl with 3 to 8 carbon atoms in the ring, alkenyl or alkynyl of 2 to 8 carbon atoms, or cycloalkyl with 3 to 8 carbon atoms in the ring, the cycloalkyl rings being unsubstituted or mono- or di-substituted by alkyl of 1 to 3 carbon atoms, and R' is alkyl of 1 to 4 carbon atoms, and their addition salts with physiologically acceptable acids, their preparation, and pharmaceutical formulations which contain these compounds and which can be used as valuable drugs in the treatment of hypertonia, coronary diseases of the heart and cardiac arrhythmias.

    8.
    发明专利
    未知

    公开(公告)号：DK272080A

    公开(公告)日：1980-06-25

    申请号：DK272080

    申请日：1980-06-25

    Applicant: BASF AG

    Inventor： TREIBER H J ,  LENKE D ,  WORSTMANN W

    IPC: A61K31/55 ,  A61K31/553 ,  A61P25/04 ,  C07D267/00 ,  C07D267/12 ,  C07D267/14 ,  C07D

    Abstract: PCT No. PCT/EP79/00080 Sec. 371 Date Jun. 26, 1980 Sec. 102(e) Date Jun. 16, 1980 PCT Filed Oct. 22, 1979 PCT Pub. No. WO80/00838 PCT Pub. Date May 1, 1980. The invention relates to novel 1,4-cycloalkano-oxazepines of the general formula where R1 is hydrogen, hydroxyl or alkoxy or acyloxy of 1 to 4 carbon atoms, R2 is a hydrocarbon radical of 1 to 3 carbon atoms, n is 1, 2 or 3 and x is 0 or 1, and of its salts with physiologically acceptable acids; processes for their preparation, and their use in therapy. The novel substances are suitable for the pharmacotherapy of pains of various origins.

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