公开(公告)号：JPH10212248A

公开(公告)日：1998-08-11

申请号：JP35366697

申请日：1997-12-22

Applicant: BASF AG

Inventor： ISOLA ARTHUR MARK ,  HOLMAN NICHOLAS JOHN ,  TOMETZKI GERALD BERNARD ,  WATTS JOHN PAUL ,  KOSER STEFAN ,  KLINTZ RALF ,  MUENSTER PETER

IPC: C07B63/02 ,  C07C41/44 ,  C07C43/225 ,  C07C45/72 ,  C07C45/85 ,  C07C49/255 ,  C07C201/16 ,  C07C205/56 ,  C07D209/08 ,  C07D209/10 ,  C07D209/48 ,  C07D235/18 ,  C07D319/06 ,  C07D487/04

Abstract: PROBLEM TO BE SOLVED: To obtain the subject compound of which oxide content is decreased by adding a metal salt to form a complex thereof with trisubstituted phosphine and separating the complex formed from the mixture. SOLUTION: A reducing agent such as a trisubstituted phosphine represented by the formula (R is H, a 1-6C alkyl; R and R are each H, a 1-6C alkyl; R and R are each H, a 1-6C alkyl; R -R are each H, a 1-6C haloalkyl) is oxidized to form the oxide. A metal salt of an alkali metal is added to the oxide in a range from 0.25-5 molar equivalent based on the oxide to effect the Mitsunobu reaction. In the reaction, the reaction mixture is kept at the temperature ranging from 0 to 120 deg.C for 16 hours at maximum, then cooled down in the temperature range from -10 deg.C - the ambient temperature to form complex. The remaining complex is separated by filtration or centrifugation to decrease the oxide.

公开(公告)号：CA2222854A1

公开(公告)日：1998-06-23

申请号：CA2222854

申请日：1997-12-22

Applicant: BASF AG

Inventor： ISOLA ARTHUR MARK ,  KLINTZ RALF ,  KOSER STEFAN ,  WATTS JOHN PAUL ,  MUENSTER PETER ,  HOLMAN NICHOLAS JOHN ,  TOMETZKI GERALD BERNARD

IPC: C07B63/02 ,  C07C41/44 ,  C07C43/225 ,  C07C45/72 ,  C07C45/85 ,  C07C49/255 ,  C07C201/16 ,  C07C205/56 ,  C07D209/08 ,  C07D209/10 ,  C07D209/48 ,  C07D235/18 ,  C07D319/06 ,  C07D487/04 ,  C07D209/42 ,  C07C41/58

Abstract: A process for reducing the level of tri-substituted phosphine, arsine and/or stibine oxide from a mixture comprising a desired product and at least one such oxide is provided, comprising the addition of a metal salt to the mixture to form a complex with the oxide, and removing the complex from the mixture. This process has particular utility for removing triphenylphosphine oxide from a mixture - a task that was previously hard to perform.