公开(公告)号：JPH10212248A

公开(公告)日：1998-08-11

申请号：JP35366697

申请日：1997-12-22

Applicant: BASF AG

Inventor： ISOLA ARTHUR MARK ,  HOLMAN NICHOLAS JOHN ,  TOMETZKI GERALD BERNARD ,  WATTS JOHN PAUL ,  KOSER STEFAN ,  KLINTZ RALF ,  MUENSTER PETER

IPC: C07B63/02 ,  C07C41/44 ,  C07C43/225 ,  C07C45/72 ,  C07C45/85 ,  C07C49/255 ,  C07C201/16 ,  C07C205/56 ,  C07D209/08 ,  C07D209/10 ,  C07D209/48 ,  C07D235/18 ,  C07D319/06 ,  C07D487/04

Abstract: PROBLEM TO BE SOLVED: To obtain the subject compound of which oxide content is decreased by adding a metal salt to form a complex thereof with trisubstituted phosphine and separating the complex formed from the mixture. SOLUTION: A reducing agent such as a trisubstituted phosphine represented by the formula (R is H, a 1-6C alkyl; R and R are each H, a 1-6C alkyl; R and R are each H, a 1-6C alkyl; R -R are each H, a 1-6C haloalkyl) is oxidized to form the oxide. A metal salt of an alkali metal is added to the oxide in a range from 0.25-5 molar equivalent based on the oxide to effect the Mitsunobu reaction. In the reaction, the reaction mixture is kept at the temperature ranging from 0 to 120 deg.C for 16 hours at maximum, then cooled down in the temperature range from -10 deg.C - the ambient temperature to form complex. The remaining complex is separated by filtration or centrifugation to decrease the oxide.

公开(公告)号：CA2280833A1

公开(公告)日：1998-08-27

申请号：CA2280833

申请日：1998-02-09

Applicant: BASF AG

Inventor： HOLMAN NICHOLAS JOHN ,  BALKENHOHL FRIEDHELM ,  KOSER STEFAN

IPC: C07D487/04 ,  C12N9/20 ,  C12P17/18 ,  C12P41/00

Abstract: The invention relates to a method for producing enantiomer-free alcohols of formula (I), where the substituents represent the following: R1 is a hydrogen or a substituted or unsubstituted C1-C6-alkyl-, C1-C6-alkoxy-, or C1-C6-alkanoyl-; R2 and R3 independently of each other represent hydrogen or a substituted or unsubstituted C1-C6-alkyl-, C1-C6-alkoxy-, C1-C6-alkanoyl, C1C6-alkylthio-, C1-C6-alkyl sulfinyl or C1-C6-alkyl sulfonyl-; and R4 is not equal R5 and independently of each other they represent either hydrogen or a substituted or unsubstituted C1-C6-alkyl-, or together with the hydrogen atoms to which they are bound form a substituted or unsubstituted C3-C6-cyclo alkylidene. The method is characterized in that racemic compounds of the formula (II), in which the substituents R1 to R5 have the meanings given above and R6 is a substituted or unsubstituted aryl-, C1-C20-alkyl-, C3-C20-alkenyl-, C3-C20-alkynyl-, are reacted with a lipase or esterase in the presence of an alcohol of the formula R7OH (III), where R7 is a substituted or unsubstituted C1-C10-alkyl-.

公开(公告)号：AU1145201A

公开(公告)日：2001-06-06

申请号：AU1145201

申请日：2000-10-27

Applicant: BASF AG

Inventor： HOLMAN NICHOLAS JOHN ,  FRIEND CHRISTOPHER LYNDON

IPC: C07D249/08 ,  C07C303/40 ,  C07C311/35 ,  C07D209/14 ,  C07D209/16 ,  C07D263/20 ,  C07D295/20 ,  C07D401/06 ,  C07D403/04 ,  C07D403/14 ,  C07D413/14

公开(公告)号：CA2389514A1

公开(公告)日：2001-05-17

申请号：CA2389514

申请日：2000-10-27

Applicant: BASF AG

Inventor： FRIEND CHRISTOPHER LYNDON ,  HOLMAN NICHOLAS JOHN

IPC: C07D249/08 ,  C07C303/40 ,  C07C311/35 ,  C07D209/14 ,  C07D209/16 ,  C07D263/20 ,  C07D295/20 ,  C07D401/06 ,  C07D403/04 ,  C07D403/14 ,  C07D413/14

Abstract: The present invention relates to a process for preparing phenylhydrazines of formula (I) in which R represents CH2SO2NHCH3, CH2CH2SO2Ph, CH2CH2SO2NHMe or a group of structure (A), (B), (C), in which a diazonium salt of formula (II) in which X represents an anion derived from hydrochloric acid, sulphuric acid, acetic acid, phosphoric acid, tetrafluoroboric acid or hydrobromic acid is reduced by a dithionite salt. The resulting phenylhydrazines can be converte d to the corresponding indole derivatives by the Fischer indole synthesis.

公开(公告)号：CA2275494A1

公开(公告)日：1998-08-27

申请号：CA2275494

申请日：1998-02-09

Applicant: BASF AG

Inventor： DINGLER CHRISTOPH ,  HOLMAN NICHOLAS JOHN

IPC: C12N9/02 ,  C07D487/04 ,  C12P17/18 ,  E03D7/00 ,  E04H1/12

Abstract: The invention relates to a method for producing enantiomer-free alcohols of formula (I) (Ia or Ib), in which the substituents represent the following; R1 represents hydrogen or a substituted or unsubstituted C1-C6-alkyl-, C1-C6-alkoxy-, or C1-C6-alkanoyl-; R2 and R3 independently of each other represent hydrogen or a substituted or unsubstituted C1-C6-alkyl-, C1-C6-alkoxy-, or C1C6-alkanoyl-, C1-C6-alkylthio-, C1-C6-alkyl sulfinyl- or C1-C6-alkyl sulfonyl; and R4 is a substituted or unsubstituted C1-C6-alkyl-, C3-C6-cycloalkyl-. Said method is characterized in that compounds of formula (II), in which the substituents R1 to R4 have the meaning given above, are reduced to compounds of formula (I) in an aqueous solution, in the presence of a carbon source and a microorganism or a reducing agent and an enzyme.

公开(公告)号：CA2222854A1

公开(公告)日：1998-06-23

申请号：CA2222854

申请日：1997-12-22

Applicant: BASF AG

Inventor： ISOLA ARTHUR MARK ,  KLINTZ RALF ,  KOSER STEFAN ,  WATTS JOHN PAUL ,  MUENSTER PETER ,  HOLMAN NICHOLAS JOHN ,  TOMETZKI GERALD BERNARD

IPC: C07B63/02 ,  C07C41/44 ,  C07C43/225 ,  C07C45/72 ,  C07C45/85 ,  C07C49/255 ,  C07C201/16 ,  C07C205/56 ,  C07D209/08 ,  C07D209/10 ,  C07D209/48 ,  C07D235/18 ,  C07D319/06 ,  C07D487/04 ,  C07D209/42 ,  C07C41/58

Abstract: A process for reducing the level of tri-substituted phosphine, arsine and/or stibine oxide from a mixture comprising a desired product and at least one such oxide is provided, comprising the addition of a metal salt to the mixture to form a complex with the oxide, and removing the complex from the mixture. This process has particular utility for removing triphenylphosphine oxide from a mixture - a task that was previously hard to perform.

公开(公告)号：CA2274247A1

公开(公告)日：1998-08-27

申请号：CA2274247

申请日：1998-02-09

Applicant: BASF AG

Inventor： HOLMAN NICHOLAS JOHN ,  BALKENHOHL FRIEDHELM ,  KOSER STEFAN

IPC: C07D487/04 ,  C12P17/18 ,  C12P41/00

Abstract: The invention relates to a method for producing enantiomer-free esters of formula (I) (Ia or Ib), where the substituents represent the following: R1 is a hydrogen or a substituted or unsubstituted C1-C6-alkyl-, C1-C6-alkoxy-, or C1-C6-alkanoyl; R2 and R3 independently of each other are hydrogen or a substituted or unsubstituted C1-C6-alkyl-, C1-C6-alkoxy-, or C1-C6-alkanoyl-, C1-C6-alkylthio-, C1-C6-alkyl sulfinyl or C1-C6-alkyl sulfonyl-; R4 is not equal to R5 and independently of each other they are either hydrogen or an substituted or unsubstituted C1-C6-alkyl-, or together with the hydrogen atoms, to which they are bound, form a substituted or unsubstituted C3-C6-cyclo alkylidene; and R6 is a substituted or unsubstituted aryl-, C1-C20-alkyl-, C3-C20-alkenyl-, C3-C20-alkynyl-, C1-C20-alkoxy-C1-C20-alkyl. The method is characterized in that racemic compounds of the formula (II), in which the substituents R1 to R5 have the meanings given above, are reacted with a lipase or esterase in the presence of vinyl esters of formula (III), where R6 has the meaning given above and R7 represents hydrogen or methyl, to form compounds of formula (I).

公开(公告)号：DK0925368T3

公开(公告)日：2002-03-25

申请号：DK98909424

申请日：1998-02-09

Applicant: BASF AG

Inventor： DINGLER CHRISTOPH ,  HOLMAN NICHOLAS JOHN

IPC: C12N9/02 ,  C07D487/04 ,  C12P17/18 ,  E03D7/00 ,  E04H1/12

Abstract: A process for preparing enantiomerically pure alcohols of the formula I (Ia or Ib)where the substituents have the following meanings:R1hydrogen or substituted or unsubstituted C1-C6-alkyl, C1-C6-alkoxy or C1-C6-alkanoyl,R2 and R3independently of one another hydrogen or substituted or unsubstituted C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkanoyl, C1-C6-alkylthio, C1-C6-alkylsulfinyl or C1-C6-alkylsulfonyl,R4substituted or unsubstituted C1-C6-alkyl, C3-C8-cycloalkyl,which comprises reducing compounds of the formula II where the substituents R1 to R4 have the abovementioned meanings in aqueous solution in the presence of a carbon source and of a microorganism or of a reducing agent, of a cofactor and of an enzyme, to compounds of the formula I.