公开(公告)号：JP2002145857A

公开(公告)日：2002-05-22

申请号：JP2001277290

申请日：2001-09-12

Applicant: BASF AG

Inventor： TIETZE LUTZ F ,  EVERS HOLGER ,  TOPKEN ENNO

IPC: C07D487/04 ,  C07B61/00 ,  C07D207/08 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C40B40/04

Abstract: PROBLEM TO BE SOLVED: To provide a process for combinatorial preparation of a substance library, having both advantages of conventional solid synthesis and liquid synthesis, but capable of substantially avoiding the disadvantages thereof. SOLUTION: This process for the combinatorial preparation of the substance library from n different compounds in an array of n different reaction solutions at n spatially separate reaction sites, is characterized in that at each of the n reaction sites (a) from in each case m reactants, in one reaction or reaction sequence, a zwitterionic compound is obtained dissolved in a polar solvent, (b) the zwitterionic compound is precipitated as a solid by addition of a nonpolar solvent, isolated and then obtained in pure form, (c) if appropriate the zwitterionic compound is further reacted, with each of the n reaction solutions differing from each of the n-1 other reaction solutions in at least one of the m reactants.