公开(公告)号：JP2002145857A

公开(公告)日：2002-05-22

申请号：JP2001277290

申请日：2001-09-12

Applicant: BASF AG

Inventor： TIETZE LUTZ F ,  EVERS HOLGER ,  TOPKEN ENNO

IPC: C07D487/04 ,  C07B61/00 ,  C07D207/08 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C40B40/04

Abstract: PROBLEM TO BE SOLVED: To provide a process for combinatorial preparation of a substance library, having both advantages of conventional solid synthesis and liquid synthesis, but capable of substantially avoiding the disadvantages thereof. SOLUTION: This process for the combinatorial preparation of the substance library from n different compounds in an array of n different reaction solutions at n spatially separate reaction sites, is characterized in that at each of the n reaction sites (a) from in each case m reactants, in one reaction or reaction sequence, a zwitterionic compound is obtained dissolved in a polar solvent, (b) the zwitterionic compound is precipitated as a solid by addition of a nonpolar solvent, isolated and then obtained in pure form, (c) if appropriate the zwitterionic compound is further reacted, with each of the n reaction solutions differing from each of the n-1 other reaction solutions in at least one of the m reactants.

公开(公告)号：WO2007071626A2

公开(公告)日：2007-06-28

申请号：PCT/EP2006069777

申请日：2006-12-15

Applicant: BASF AG ,  ERNST MARTIN ,  KUSCHE ANDREAS ,  HEYDRICH GUNNAR ,  GRAFMANS HORST ,  EVERS HOLGER ,  MELDER JOHANN-PETER ,  MEISSNER HARALD ,  FREUND TORSTEN

Inventor： ERNST MARTIN ,  KUSCHE ANDREAS ,  HEYDRICH GUNNAR ,  GRAFMANS HORST ,  EVERS HOLGER ,  MELDER JOHANN-PETER ,  MEISSNER HARALD ,  FREUND TORSTEN

IPC: C07C231/12 ,  C07C237/06

CPC classification number: C07C231/14 ,  Y02P20/582 ,  C07C237/06

Abstract: The invention relates to a method for producing aminoalkane acid amines by reacting cyanoalkane acid esters with a) ammonia or an amine and b) hydrogen in the presence of a catalyst, the reaction with component b) being started simultaneously or a maximum of 100 minutes after starting to react the cyanoalkane acid ester with component a).

Abstract translation: 本发明涉及一种用于Aminoalkansäureamiden的制备方法通过用）氨或胺Cyanalkansäureestern反应，和b）在催化剂的存在下，氢气其中Cyanalkansäureesters的执行开始后在同一时间与组分b）的反应或不晚于最大100分钟 从组件a）开始。

公开(公告)号：WO2006114417A2

公开(公告)日：2006-11-02

申请号：PCT/EP2006061823

申请日：2006-04-25

Applicant: BASF AG ,  EVERS HOLGER ,  MELDER JOHANN-PETER ,  HIMMEL WALTER ,  KRUG THOMAS ,  GERLACH TILL ,  JOEDECKE MICHAEL ,  NOUWEN JAN ,  ROETTGER RODERICH

Inventor： EVERS HOLGER ,  MELDER JOHANN-PETER ,  HIMMEL WALTER ,  KRUG THOMAS ,  GERLACH TILL ,  JOEDECKE MICHAEL ,  NOUWEN JAN ,  ROETTGER RODERICH

IPC: C07C209/16

CPC classification number: C07D295/033 ,  C07C209/16 ,  C07C209/60 ,  C07C213/04 ,  C07C211/10 ,  C07C211/14 ,  C07C215/08 ,  C07C215/12 ,  C07C215/14

Abstract: Disclosed is a method for producing ethyleneamines, in which ethylene oxide (EO) is continuously reacted with ammonia on an inorganic ion exchanger as a heterogeneous catalyst in anhydrous conditions in a first reaction stage, the obtained reaction product containing monoethanolamine (MEOA), diethanolamine (DEOA), and triethanolamine (TEOA) at a weight ratio MEOA: DEOA: TEOA = 80 - 94: 5.9 - 15: 0.1 - 5, and the reaction product is then continuously reacted with ammonia in the presence of hydrogen and a heterogeneous hydrogenation catalyst in a second reaction stage.

Abstract translation: 一种用于制备Ethyienaminen得到（EO）作为非均相催化剂的方法进行反应在第一反应步骤中环氧乙烷与无水的条件下氨，连续的无机离子交换剂，一乙醇胺的所得反应产物（MEOA），在重量比的二乙醇胺（DEOA）和三乙醇胺（TEOA） MEOA：DEOA：TEOA = 80-94：5.9至15：0,1 - 5包括，并将该反应产物然后在氢气存在下和非均相氢化催化剂与氨的第二反应步骤连续进行反应。

公开(公告)号：DE102005060803A1

公开(公告)日：2007-06-28

申请号：DE102005060803

申请日：2005-12-20

Applicant: BASF AG

Inventor： ERNST MARTIN ,  KUSCHE ANDREAS ,  HEYDRICH GUNNAR ,  GRAFMANS HORST ,  EVERS HOLGER ,  MELDER JOHANN-PETER ,  MEISNER HARALD ,  FREUND TORSTEN

IPC: C07C231/06

Abstract: Preparation of aminoalkanoic acid amide comprises reaction of cyanoalkanoic acid ester with (a) at least a mol-equivalent of ammonia or amine, and (b) hydrogen in the presence of catalyst, at increased pressure, where optionally the formed intermediate stages are not isolated and the reaction with (b) takes place simultaneously or less than 100 minutes, after the beginning of the reaction of cyanoalkanoic acid ester with (a).

公开(公告)号：DE10359811A1

公开(公告)日：2005-07-21

申请号：DE10359811

申请日：2003-12-19

Applicant: BASF AG

Inventor： EVERS HOLGER ,  MELDER JOHANN-PETER ,  BENISCH CHRISTOPH ,  FRAUENKRON MATTHIAS ,  GERLACH TILL ,  ALBA PEREZ ANA ,  NOUWEN JAN

IPC: C07C209/64 ,  C07C211/14 ,  C07C209/26 ,  B01J23/70 ,  C07C211/11

公开(公告)号：DE102005047458A1

公开(公告)日：2007-04-12

申请号：DE102005047458

申请日：2005-09-30

Applicant: BASF AG

Inventor： HOFFER BRAM WILLEM ,  EVERS HOLGER ,  KUBANEK PETR ,  GERLACH TILL ,  MELDER JOHANN-PETER ,  FUNKE FRANK ,  FRAUENKRON MATTHIAS ,  SCHMIDTKE HELMUT

IPC: C07C209/64 ,  B01J23/70 ,  B01J35/02 ,  C07C209/60 ,  C07C209/84 ,  C07C211/14 ,  C07D295/00 ,  C07D295/13

Abstract: Preparation of aminodiglycol and morpholine comprises reacting diethyleneglycol with ammonia in the presence of a transition metal heterogeneous catalyst. The catalytically active mass of the catalyst, before treatment with hydrogen, contains oxygen-containing compounds of aluminum and/or zirconium, copper, nickel and cobalt, and that the catalyst molding is in spherical or strand form has a diameter of less than 3 mm, in tablet form has a height of less than 3 mm and in all other geometrical shapes with an equivalent diameter (L is I/a) of less than 0.70 mm. Preparation of aminodiglycol and morpholine comprises reacting diethyleneglycol with ammonia in the presence of a transition metal heterogeneous catalyst. The catalytically active mass of the catalyst, before treatment with hydrogen, contains oxygen-containing compounds of aluminum and/or zirconium, copper, nickel and cobalt, and that the catalyst molding is in spherical or strand form has a diameter of less than 3 mm, in tablet form has a height of less than 3 mm and in all other geometrical shapes with an equivalent diameter (L is I/a) of less than 0.70 mm (where a is the external surface per volume unit (mm s2>/mm p3>), with the formula (a is A p/V p), in which A pis the external surface of the catalyst particle (mm s2>) and V pis the volume of the catalyst particle (mm p3>)).

公开(公告)号：DE102005044090A1

公开(公告)日：2007-03-22

申请号：DE102005044090

申请日：2005-09-15

Applicant: BASF AG

Inventor： EVERS HOLGER ,  MELDER JOHANN-PETER ,  PREISS THOMAS ,  MEISNER HARALD

IPC: C07C253/30 ,  C07B43/04 ,  C07C227/06 ,  C07C229/00 ,  C07C255/24

Abstract: Preparation of beta -aminopropionic acid derivatives by reacting primary/secondary amine with an acrylic acid derivative, comprises reacting first primary or secondary amine with acrylic acid derivative to obtain a first beta -aminopropionic acid derivative and unreacted acrylic acid derivative; and completely reacting the unreacted acrylic acid derivative with a second secondary amine to obtain a second beta -aminopropionic acid derivative, where the reaction mixture contains beta -aminopropionic acid derivative and unreacted secondary amine. Preparation of beta -aminopropionic acid derivatives by reacting a primary/ secondary amine with an acrylic acid derivative, comprises reacting first primary or secondary amine as value amine with acrylic acid derivative to obtain reaction mixture containing a first beta -aminopropionic acid derivative as an end product in addition with unreacted acrylic acid derivative, where the amount of the acrylic acid derivative is large, when compared with the value amine; and completely reacting the unreacted acrylic acid derivative with a second secondary amine as a trapping amine to obtain a second beta -aminopropionic acid derivative, where the reaction mixture contains first beta -aminoproionic acid derivative as end product, second beta -aminopropionic acid derivative and unreacted secondary amine.

公开(公告)号：DE10336003A1

公开(公告)日：2005-02-24

申请号：DE10336003

申请日：2003-08-01

Applicant: BASF AG

Inventor： FRAUENKRON MATTHIAS ,  KRUG THOMAS ,  EVERS HOLGER ,  MELDER JOHANN-PETER ,  ROETTGER RODERICH ,  SIEGERT MARKUS ,  GERLACH TILL ,  NOUWEN JAN

IPC: C07C209/64 ,  C07C211/14 ,  C07C209/16

Abstract: Production of ethylene amine compounds (I) comprises continuous reaction of ethylene diamine in the presence of a heterogeneous catalyst in a reaction column.

公开(公告)号：DE10335991A1

公开(公告)日：2005-02-24

申请号：DE10335991

申请日：2003-08-01

Applicant: BASF AG

Inventor： FRAUENKRON MATTHIAS ,  EVERS HOLGER ,  MELDER JOHANN-PETER ,  ROETTGER RODERICH ,  SIEGERT MARKUS ,  GERLACH TILL ,  NOUWEN JAN ,  KRUG THOMAS

IPC: C07C209/16 ,  C07C211/10 ,  C07C211/14

Abstract: Preparation of ethyleneamines by reacting monoethanolamine (MEOA) with ammonia in the presence of a catalyst in a reactor (1) and separating the resulting reaction product, where ethylenediamine (EDA) obtained in the separation is reacted in a separate reactor (2) in the presence of a catalyst to give diethylenetriamine (DETA), and the resulting reaction product is passed to the separation of the reaction product resulting from reactor 1.

公开(公告)号：AT358114T

公开(公告)日：2007-04-15

申请号：AT04740778

申请日：2004-07-08

Applicant: BASF AG

Inventor： FRAUENKRON MATTHIAS ,  EVERS HOLGER ,  MELDER JOHANN-PETER ,  ROETTGER RODERICH ,  SIEGERT MARKUS ,  GERLACH TILL ,  NOUWEN JAN ,  KRUG THOMAS

IPC: C07C209/16 ,  C07C211/10 ,  C07C211/14

Abstract: Preparation of ethyleneamines by reacting monoethanolamine (MEOA) with ammonia in the presence of a catalyst in a reactor (1) and separating the resulting reaction product, where ethylenediamine (EDA) obtained in the separation is reacted in a separate reactor (2) in the presence of a catalyst to give diethylenetriamine (DETA), and the resulting reaction product is passed to the separation of the reaction product resulting from reactor 1.