公开(公告)号：JPH03151326A

公开(公告)日：1991-06-27

申请号：JP28735690

申请日：1990-10-26

Applicant: BASF AG

Inventor： DEIITAA HORUN ,  RUTSUTSU ENDO ,  RAINHARUTO SHIYUPENGURAA ,  HANSUUYURUGEN KURAUZE ,  YURUGEN ERUTSUNAA

IPC: A61K9/14 ,  A61K9/50 ,  A61K38/00 ,  C07K1/00 ,  C07K14/52 ,  C07K14/555 ,  C07K14/57 ,  C07K14/705 ,  C07K14/81

Abstract: PURPOSE: To stabilize a peptide bond against the hydrolysis or decomposition with an enzyme and improve the bioavailability by micronizing a pharmaceutical agent having the peptide bond according to a specific method. CONSTITUTION: A pharmaceutical agent having a peptide bond, as necessary, together with a surfactant, is dissolved in a volatile water-miscible organic solvent (the one, miscible with water to at least 10%, boiling at