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    PHARMACEUTICAL PREPARATION IN SOLID RETARDING FORM
    1.
    发明专利
    PHARMACEUTICAL PREPARATION IN SOLID RETARDING FORM 失效

    公开(公告)号：JPH05194197A

    公开(公告)日：1993-08-03

    申请号：JP31006092

    申请日：1992-11-19

    Applicant: BASF AG

    Inventor： BUINFURIITO MIYURAA ,  RAINHARUTO SHIYUPENGURAA ,  SUBUEN GURABOFUSUKII ,  AKUSERU ZANNAA

    IPC: A61K9/20 ,  A61K9/22

    Abstract: PURPOSE: To prepare a sustained release formulation of a solid pharmaceutical preparation by an extruding and continuous forming method for allowing the treatment to successively progress with a high throughput when the material loss is slight. CONSTITUTION: A sustained release formulation is prepared by melt-extruding a mixture of an active ingredient of a pharmaceutical preparation with a polymer melt comprising (a) a water-insoluble poly(meth)acrylate, (b) a water-soluble hydroxyalkyl cellulose having 2-3 carbon atoms in the hydroxyalkyl group or hydroxyalkylmethyl cellulose, or a N-vinylpyrrolidone polymer having vinyl acetate, or a mixture of preceding two, (c) one or more conventional pharmaceutical auxiliaries, and successively forming the molten mixture.

    SUSTAINED RELEASE PREPARATION OF WATER-SOLUBLE SOLID MEDICAL EFFECTIVE SUBSTANCE AND ITS MANUFACTURE
    3.
    发明专利
    SUSTAINED RELEASE PREPARATION OF WATER-SOLUBLE SOLID MEDICAL EFFECTIVE SUBSTANCE AND ITS MANUFACTURE 失效

    公开(公告)号：JPH06211649A

    公开(公告)日：1994-08-02

    申请号：JP28912693

    申请日：1993-11-18

    Applicant: BASF AG

    Inventor： KURAUSU HARUTO ,  HARUTOMUUTO HIPUSUTO ,  YURUGEN DEMUBOFUSUKII ,  RAINHARUTO SHIYUPENGURAA ,  ERUNSUTO FURAIKU

    IPC: A61K9/32 ,  A61K9/22 ,  A61K9/28 ,  A61K9/50 ,  A61K9/52 ,  A61K47/34

    Abstract: PURPOSE: To prepare the subject agent which shows reproducible and uniform release behavior irrespective of layer thickness and is pollution-free and capable of having a high content of active substance. CONSTITUTION: This agent comprises nuclei (carrier) each containing or consisting of a pharmaceutically-active substance, and at least one coating layer which is firmly deposited on the surface of each of the nuclei so as to hinder the active substance from being diffused and also has a 0.01 to 10 μm thickness and the formation of which comprises coating the active substance carrier with a chemical network structure by using a plasma-aided chemical deposition technique. This coating layer contains at least elemental silicon and elemental carbon, preferably in amounts sufficient to provide a 1 to 40 atom % Si content and a 60 to 99 atom % C content, respectively. This preparation of the agent comprises forming the coating layer on the active substance carrier under certain moving conditions by concurrently performing deposition of the coating layer constituents and formation of the chemical network structure in an enclosed space through plasma-aided decomposition of a gaseous mixture contg. at least one organosilicic compound (preferably, hexamethyldisiloxane).

    HYDROPHILIC POWDERY THEOPHYLINE MOLDING AND MANUFACTURE THEREOF
    5.
    发明专利
    HYDROPHILIC POWDERY THEOPHYLINE MOLDING AND MANUFACTURE THEREOF 失效

    公开(公告)号：JPH02243630A

    公开(公告)日：1990-09-27

    申请号：JP20493889

    申请日：1989-08-09

    Applicant: BASF AG

    Inventor： DEIITOMARU HORUN ,  GETSU KURIYUGAA ,  RAINHARUTO SHIYUPENGURAA

    IPC: A61K9/14 ,  A61K9/16 ,  A61K31/52 ,  A61K47/24 ,  A61K47/26 ,  A61P11/08

    Abstract: PURPOSE: To obtain the subject molded form for oral use, comprising theophylline, lecithin and a saccharide, and, as the case may be, a fluidizing agent and additive in specified proportions, extraordinarily highly dispersible in water just before taken, and wisely suppressed in the bitter taste of the theophylline. CONSTITUTION: This powdery molded form comprises (A) 5-15 (pref. 8-12)wt.% of theophylline, (B) 15-30 (pref. 20-25)wt.% of lecithin, (C) 45-80 (pref. 55-70)wt.% of a saccharide (pref. sucrose), and, as the case may be, (D) 0-50 (pref. 1-3)wt.% of a fluidizing agent, pref. porous silica gen. and (E) 0-30 (pref. 0.1-5)wt.% of a food color, gustatory ingredient and/or antioxidant. This molded form is obtained by the following process: The component C is dissolved at 70-100 deg.C in an aqueous solution of the component A, and the components B and E are then dispersed or dissolved in the resultant solution, the resultant hot solution is evaporated to dryness. The resultant dry powder is sieved followed by, as the case may be, addition of the component D.

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