公开(公告)号：WO1994022842A1

公开(公告)日：1994-10-13

申请号：PCT/EP1994000870

申请日：1994-03-19

Applicant: BASF AKTIENGESELLSCHAFT

Inventor： BASF AKTIENGESELLSCHAFT ,  JANSSEN, Bernd ,  KLING, Andreas ,  MÜLLER, Stefan ,  RITTER, Kurt ,  SCHLECKER, Rainer ,  KEILHAUER, Gerhard ,  ROMERDAHL, Cynthia ,  TRAUGOTT, Ulrich

IPC: C07D261/08

CPC classification number: C07D207/333 ,  C07D209/52 ,  C07D211/14 ,  C07D213/30 ,  C07D261/08 ,  C07D261/18 ,  C07D263/14 ,  C07D271/06 ,  C07D277/24 ,  C07D285/12 ,  C07D295/088 ,  C07D317/58 ,  C07D333/16 ,  C07D413/12 ,  C07D417/12 ,  C07F9/650952

Abstract: This invention relates to 1-amino-3-phenoxy-propane-derivatives of formula (1) (in which A, B, R, R , X and Z are defined as in the specification described) and methods for their preparation. These compounds may be used as modulators of multi-drug resistance in cancer chemotherapy and for circumvention of resistance in the treatment of malaria.

Abstract translation: 本发明涉及式（1）的1-氨基-3-苯氧基 - 丙烷衍生物（其中A，B，R，R x，X和Z如所述的说明书所定义）及其制备方法 。 这些化合物可用作癌症化疗中多重耐药性的调节剂，并用于规避疟疾治疗中的抵抗力。

公开(公告)号：EP0673378A1

公开(公告)日：1995-09-27

申请号：EP94901898.0

申请日：1993-11-27

Applicant: BASF Aktiengesellschaft

Inventor： SCHLECKER, Rainer ,  TREIBER, Hans-Joerg ,  BEHL, Berthold ,  HOFMANN, Hans, Peter

IPC: A61K31 ,  A61P9 ,  A61P25 ,  C07D471 ,  C07D487 ,  C07D491 ,  C07D495

CPC classification number: C07D487/04 ,  C07D495/14

Abstract: Described are triazolopyrimidones of the formula (I) in which A, B and X are as defined in the description, plus their preparation and use. Such compounds are suitable for use in the treatment of disorders of the central nervous system, in particular conditions caused by acute or chronic disorders of the circulation and/or of cell metabolism, such as ischaemic cerebral insults, vascular encephalopathy and resulting demential illnesses, epilepsy, Parkinsons's disease, depression, migraine, as well as traumatic lesions of the brain and spinal cord.

公开(公告)号：EP0691962B1

公开(公告)日：2000-09-13

申请号：EP94911931.7

申请日：1994-03-19

Applicant: BASF AKTIENGESELLSCHAFT

Inventor： JANSSEN, Bernd ,  KLING, Andreas ,  MÜLLER, Stefan ,  RITTER, Kurt ,  SCHLECKER, Rainer ,  KEILHAUER, Gerhard ,  ROMERDAHL, Cynthia ,  TRAUGOTT, Ulrich

IPC: C07D261/08 ,  C07D261/18 ,  A61K31/42 ,  C07D295/08 ,  C07D413/12 ,  A61K31/495 ,  C07D333/16 ,  C07D285/12 ,  C07D213/30 ,  C07D263/14

CPC classification number: C07D207/333 ,  C07D209/52 ,  C07D211/14 ,  C07D213/30 ,  C07D261/08 ,  C07D261/18 ,  C07D263/14 ,  C07D271/06 ,  C07D277/24 ,  C07D285/12 ,  C07D295/088 ,  C07D317/58 ,  C07D333/16 ,  C07D413/12 ,  C07D417/12 ,  C07F9/650958

公开(公告)号：EP0673249B1

公开(公告)日：1999-03-17

申请号：EP94902687.6

申请日：1993-12-06

Applicant: BASF Aktiengesellschaft

Inventor： SCHLECKER, Rainer ,  TREIBER, Hans-Jörg ,  BEHL, Berthold ,  HOFMANN, Hans Peter

IPC: A61K31/505

CPC classification number: A61K31/505

Abstract: Described is the use of triazoloquinazolines in the preparation of drugs for use in the treatment of diseases of the central nervous system. The triazoloquinazolines have formula (I) in which R , R and X are as defined in the description.

公开(公告)号：EP0673377B1

公开(公告)日：1997-02-26

申请号：EP94901897.2

申请日：1993-11-27

Applicant: BASF AKTIENGESELLSCHAFT

Inventor： SCHLECKER, Rainer ,  TREIBER, Hans-Joerg ,  BEHL, Berthold ,  HOFMANN, Hans, Peter

IPC: C07D487/04 ,  A61K31/505

CPC classification number: C07D487/04

Abstract: Disclosed are new triazoloquinazolines having the formula (I), in which A, X, R?1 and R2¿ have the meaning given in the description, as well as their production. These compounds (I) are suitable as active substances for human and veterinary medicaments and may be used for producing drugs for treating neurodegenerative diseases and neurotoxic disorders of the central nervous system, as well as for preparing spasmolytic, anti-epileptic, anxiolytic and anti-depressive drugs.

公开(公告)号：EP0641324A1

公开(公告)日：1995-03-08

申请号：EP93909981.0

申请日：1993-05-13

Applicant: BASF Aktiengesellschaft

Inventor： HELLENDAHL, Beate ,  SCHLECKER, Rainer ,  ROEHL, Franz ,  ZIPPLIES, Matthias ,  RASCHACK, Manfred ,  HAFNER, Matthias

IPC: A61K31 ,  A61P9 ,  A61P31 ,  C07D217

CPC classification number: C07D217/06 ,  A61K31/47 ,  C07D217/04

Abstract: Medicament for oral administration which contains as active substance per individual dose, besides the customary galenic auxiliaries, 10 to 1000 mg of a compound of general formula (I) or (II) in which W is a carbonyl group or a single bond, R1 is a hydrogen atom or a group of the general formula R3CO in which R3 is a lower alkyl, lower alkoxy, mono lower alkylamino or di lower alkylamino group, R2 is an alkyl residue with 3 to 20 carbon atoms which may be branched or unbranched and contain 1 to 3 double bonds, a saturated cycle of 3 to 7 carbon atoms integrated into the chain or as substituent, or may be substituted by one or more aromatic rings or contain an oxygen or sulphur atom, as a racemate and as isolated enantiomers; or the addition salt thereof with a physiologically acceptable acid, and the active substances themselves insofar as they are novel.

公开(公告)号：EP0673378B1

公开(公告)日：1997-03-12

申请号：EP94901898.0

申请日：1993-11-27

Applicant: BASF Aktiengesellschaft

Inventor： SCHLECKER, Rainer ,  TREIBER, Hans-Joerg ,  BEHL, Berthold ,  HOFMANN, Hans, Peter

IPC: C07D487/04 ,  C07D495/14 ,  A61K31/505 ,  C07D491/147 ,  C07D471/14

CPC classification number: C07D487/04 ,  C07D495/14

Abstract: Described are triazolopyrimidones of the formula (I) in which A, B and X are as defined in the description, plus their preparation and use. Such compounds are suitable for use in the treatment of disorders of the central nervous system, in particular conditions caused by acute or chronic disorders of the circulation and/or of cell metabolism, such as ischaemic cerebral insults, vascular encephalopathy and resulting demential illnesses, epilepsy, Parkinsons's disease, depression, migraine, as well as traumatic lesions of the brain and spinal cord.

公开(公告)号：EP0691962A1

公开(公告)日：1996-01-17

申请号：EP94911931.0

申请日：1994-03-19

Applicant: BASF AKTIENGESELLSCHAFT

Inventor： JANSSEN, Bernd ,  KLING, Andreas ,  MÜLLER, Stefan ,  RITTER, Kurt ,  SCHLECKER, Rainer ,  KEILHAUER, Gerhard ,  ROMERDAHL, Cynthia ,  TRAUGOTT, Ulrich

IPC: C07D295 ,  A61K31 ,  A61P35 ,  C07D207 ,  C07D209 ,  C07D211 ,  C07D213 ,  C07D215 ,  C07D261 ,  C07D263 ,  C07D271 ,  C07D277 ,  C07D285 ,  C07D307 ,  C07D317 ,  C07D333 ,  C07D413 ,  C07D417 ,  C07D521 ,  C07F9

CPC classification number: C07D207/333 ,  C07D209/52 ,  C07D211/14 ,  C07D213/30 ,  C07D261/08 ,  C07D261/18 ,  C07D263/14 ,  C07D271/06 ,  C07D277/24 ,  C07D285/12 ,  C07D295/088 ,  C07D317/58 ,  C07D333/16 ,  C07D413/12 ,  C07D417/12 ,  C07F9/650958

Abstract: This invention relates to 1-amino-3-phenoxy-propane-derivatives of formula (1) (in which A, B, R, Rx, X and Z are defined as in the specification described) and methods for their preparation. These compounds may be used as modulators of multi-drug resistance in cancer chemotherapy and for circumvention of resistance in the treatment of malaria.

公开(公告)号：EP0673377A1

公开(公告)日：1995-09-27

申请号：EP94901897.0

申请日：1993-11-27

Applicant: BASF Aktiengesellschaft

Inventor： SCHLECKER, Rainer ,  TREIBER, Hans-Joerg ,  BEHL, Berthold ,  HOFMANN, Hans, Peter

IPC: A61K31 ,  A61P25 ,  C07D487

CPC classification number: C07D487/04

Abstract: Disclosed are new triazoloquinazolines having the formula (I), in which A, X, R?1 and R2¿ have the meaning given in the description, as well as their production. These compounds (I) are suitable as active substances for human and veterinary medicaments and may be used for producing drugs for treating neurodegenerative diseases and neurotoxic disorders of the central nervous system, as well as for preparing spasmolytic, anti-epileptic, anxiolytic and anti-depressive drugs.

公开(公告)号：EP0673249A1

公开(公告)日：1995-09-27

申请号：EP94902687.0

申请日：1993-12-06

Applicant: BASF Aktiengesellschaft

Inventor： SCHLECKER, Rainer ,  TREIBER, Hans-Jörg ,  BEHL, Berthold ,  HOFMANN, Hans Peter

IPC: C07D487 ,  A61K31 ,  A61P25

CPC classification number: A61K31/505

Abstract: Described is the use of triazoloquinazolines in the preparation of drugs for use in the treatment of diseases of the central nervous system. The triazoloquinazolines have formula (I) in which R1, R2 and X are as defined in the description.