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    Recombinant production of peptides
    1.
    发明专利
    Recombinant production of peptides 未知

    公开(公告)号：NZ615847A

    公开(公告)日：2014-11-28

    申请号：NZ61584710

    申请日：2010-06-02

    Applicant: BASF SE

    Inventor： SCHWALB CARSTEN ,  HUMMERICH DANIEL ,  BRUSER HEIKE ,  LIEBMANN BURGHARD ,  FEHR MARKUS

    IPC: A61K38/16 ,  C07K14/47 ,  C12N15/62 ,  C12N15/74

    Abstract: Disclosed is a precursor protein comprising a cleavable sequence of desired peptide (Pep) elements and auxiliary peptide (Aux’) elements of the general formula (Pep-Aux’)x or (Aux’-Pep)x where x >1, wherein: the Aux’ elements are identical or different and comprise an amphiphilic alphahelix-forming peptide, said amphiphilic peptide comprising a sequence segment of at least seven peptidically linked amino acids capable of forming an amphiphilic alpha-helix, wherein the amino acid residues of said helix in its vertical projection are separated into a hydrophobic half and a hydrophilic half of the helix, the hydrophobic half of the helix having at least 3 adjacent, in the vertical projection, identical or different hydrophobic amino acid residues, and the hydrophilic half of the helix having at least 3 adjacent, in the vertical projection, identical or different hydrophilic amino acid residues; the Pep elements are identical or different and comprise the amino acid sequence of identical or different peptide molecules having a sequence length of 5 to 70 amino acid residues; the Pep elements are flanked by cleavage sequences which enable the Pep elements to be specifically cleaved out of the precursor protein; and Pep is a cationic antimicrobial peptide and Aux’ is an anionic peptide forming an amphiphilic alpha helix. Further disclosed is the use of an amphiphilic peptide as protective peptide for recombinantly producing an antimicrobial desired peptide different therefrom; wherein said amphiphilic peptide comprises a sequence section of at least seven peptidically linked amino acids capable of forming an amphiphilic alpha-helix, wherein the amino acid residues of said helix in its vertical projection are separated into a hydrophobic half and a hydrophilic half of the helix, the hydrophobic half of the helix having at least 3 adjacent, in the vertical projection, identical or different hydrophobic amino acid residues, and the hydrophilic half of the helix having at least 3 adjacent, in the vertical projection, identical or different hydrophilic amino acid residues.

    ANTIFUNGAL PAENIBACILLUS STRAINS, FUSARICIDIN-TYPE COMPOUNDS, AND THEIR USE
    2.
    发明专利
    ANTIFUNGAL PAENIBACILLUS STRAINS, FUSARICIDIN-TYPE COMPOUNDS, AND THEIR USE 未知

    公开(公告)号：CA2956880A1

    公开(公告)日：2016-02-11

    申请号：CA2956880

    申请日：2015-08-04

    Applicant: BASF SE

    Inventor： SIEPE ISABELLA ,  BRUSER HEIKE ,  KLAPPACH KRISTIN ,  SCHNEIDER KARL-HEINRICH ,  SPROTE PETRA ,  HAGE KERSTIN ,  BLANZ BIRGIT ,  THINES ECKHARD ,  ANTELO LUIS ,  SANDJO LOUIS PERGAUD ,  OPATZ TILL

    IPC: C12N1/20 ,  A01N63/00 ,  A01N63/02 ,  A01P3/00 ,  C07K7/06 ,  C12N15/31 ,  C12P21/02 ,  C12P21/04

    Abstract: The present invention relates to novel isolated bacterial strains, which are members of the genus Paenibacillus, originally isolated from soil and showing antagonistic activity against a broad range of pathogens and being capable of producing antimicrobial metabolites. It was found that the strains Lu16774 and Lu17007 belong to a novel subspecies named Paenibacillus polymyxa ssp. plantarum while the strain Lu17015 belongs to a novel species which is proposed to be Paenibacillus epiphyticus. The present invention also relates to microbial pesticide compositions comprising at least one of such novel bacterial strains, whole culture broth or a cell-free extract or a fraction thereof or at least one metabolite thereof, and/or a mutant of at least one of said novel bacterial strains having all the identifying characteristics of the respective bacterial strain or whole culture broth, cell-free extract, fraction and/or metabolite of the mutant thereof showing antagonistic activity against plant pathogens. The present invention also relates to a method of controlling or suppressing plant pathogens or preventing plant pathogen infections by applying such composition. The present invention also relates to novel fusaricidin-type compounds which are metabolites produced by the strains of the present invention.

    PRODUCCION RECOMBINANTE DE PEPTIDOS
    4.
    发明专利
    PRODUCCION RECOMBINANTE DE PEPTIDOS 未知

    公开(公告)号：PE20121033A1

    公开(公告)日：2012-08-02

    申请号：PE2011002049

    申请日：2010-06-02

    Applicant: BASF SE

    Inventor： HUMMERICH DANIEL ,  LIEBMANN BURGHARD ,  FEHR MARCUS ,  SCHWALB CARSTEN ,  BRUSER HEIKE

    IPC: A61K38/16 ,  C07K14/47 ,  C12N15/62 ,  C12N15/74

    Abstract: REFERIDA A UNA PROTEINA PRECURSORA CARACTERIZADA PORQUE COMPRENDE UNA SECUENCIA REPETITIVA, QUE PUEDE SER ESCINDIDA DE LOS ELEMENTOS DE PEPTIDO DESEADO (Pep) Y LOS ELEMENTOS DE PEPTIDO AUXILIAR (Aux) DE LA FORMULA GENENRAL (Pep-Aux)x, (Aux-Pep)x, DONDE x>1; LOS ELEMENTOS Aux SON IDENTICOS O DIFERENTES Y COMPRENDEN ELEMENTOS DE SECUENCIAS DE AMINOACIDOS QUE IMPARTEN A DICHA PROTEINA PRECURSORA PROPIEDADES DE AUTOENSAMBLAJE; LOS ELEMENTOS Pep SON IDENTICOS O DIFERENTES Y COMPRENDEN LAS SECUENCIAS DE AMINOACIDOS DE MOLECULAS PEPTIDICAS IDENTICAS O DIFERENTES Y COMPRENDEN UNA SECUENCIA DE AMINOACIDOS SELECCIONADA DE SEQ ID NO: 20 o SEQ ID NO: 29 A 67. LOS ELEMENTOS Pep Y Aux FORMAN ENLACES PEPTIDICOS ENTRE SI Y EL ENLACE PEPTIDICO ES ESPECIFICAMENTE ESCINDIBLE QUIMICAMENTE O ENZIMATICAMENTE; ADEMAS, AL MENOS UN PEPTIDO Aux, COMPRENDE UN ELEMENTO DE PEPTIDO PROTECTOR (SU) QUE TIENE UN PORCION INCREMENTADA DE DE RESIDUOS DE AMINOACIDOS DE CARGA NEGATIVA CAPAZ DE FORMAR UNA ESTRUCTURA HELICOIDAL ANFIFILICASELECCIONADA DE LAS SECUENCIAS DE AMINOACIDOS SEQ ID NO: 16 A SEQ ID NO:19 Y SEQ ID NO: DICHA PROTEINA PRECURSORA ES PRODUCIDA POR UNA CEPA RECOMBINANTE DE E. COLI Y ES UTIL EN LA PRODUCCION DE PEPTIDOS POR MEDIOS BIOTECNOLOGICOS

    PRODUCCION RECOMBINANTE DE PEPTIDOS
    7.
    发明专利
    PRODUCCION RECOMBINANTE DE PEPTIDOS 未知

    公开(公告)号：PE10332012A1

    公开(公告)日：2012-08-02

    申请号：PE0020492011

    申请日：2010-06-02

    Applicant: BASF SE

    Inventor： HUMMERICH DANIEL ,  LIEBMANN BURGHARD ,  FEHR MARCUS ,  SCHWALB CARSTEN ,  BRUSER HEIKE

    IPC: A61K38/16 ,  C07K14/47 ,  C12N15/62 ,  C12N15/74

    CPC classification number: C07K14/4723 ,  C07K2319/00 ,  C07K2319/50 ,  C12N15/62 ,  C12P21/06

    Abstract: REFERIDA A UNA PROTEINA PRECURSORA CARACTERIZADA PORQUE COMPRENDE UNA SECUENCIA REPETITIVA, QUE PUEDE SER ESCINDIDA DE LOS ELEMENTOS DE PEPTIDO DESEADO (Pep) Y LOS ELEMENTOS DE PEPTIDO AUXILIAR (Aux) DE LA FORMULA GENENRAL (Pep-Aux)x, (Aux-Pep)x, DONDE x>1; LOS ELEMENTOS Aux SON IDENTICOS O DIFERENTES Y COMPRENDEN ELEMENTOS DE SECUENCIAS DE AMINOACIDOS QUE IMPARTEN A DICHA PROTEINA PRECURSORA PROPIEDADES DE AUTOENSAMBLAJE; LOS ELEMENTOS Pep SON IDENTICOS O DIFERENTES Y COMPRENDEN LAS SECUENCIAS DE AMINOACIDOS DE MOLECULAS PEPTIDICAS IDENTICAS O DIFERENTES Y COMPRENDEN UNA SECUENCIA DE AMINOACIDOS SELECCIONADA DE SEQ ID NO: 20 o SEQ ID NO: 29 A 67. LOS ELEMENTOS Pep Y Aux FORMAN ENLACES PEPTIDICOS ENTRE SI Y EL ENLACE PEPTIDICO ES ESPECIFICAMENTE ESCINDIBLE QUIMICAMENTE O ENZIMATICAMENTE; ADEMAS, AL MENOS UN PEPTIDO Aux, COMPRENDE UN ELEMENTO DE PEPTIDO PROTECTOR (SU) QUE TIENE UN PORCION INCREMENTADA DE DE RESIDUOS DE AMINOACIDOS DE CARGA NEGATIVA CAPAZ DE FORMAR UNA ESTRUCTURA HELICOIDAL ANFIFILICASELECCIONADA DE LAS SECUENCIAS DE AMINOACIDOS SEQ ID NO: 16 A SEQ ID NO:19 Y SEQ ID NO: DICHA PROTEINA PRECURSORA ES PRODUCIDA POR UNA CEPA RECOMBINANTE DE E. COLI Y ES UTIL EN LA PRODUCCION DE PEPTIDOS POR MEDIOS BIOTECNOLOGICOS

    Antifungal Paenibacillus strains, fusaricidin-type compounds, and their use
    8.
    发明专利
    Antifungal Paenibacillus strains, fusaricidin-type compounds, and their use 未知

    公开(公告)号：AU2022200285A1

    公开(公告)日：2022-02-10

    申请号：AU2022200285

    申请日：2022-01-17

    Applicant: BASF SE

    Inventor： SIEPE ISABELLA ,  BRUSER HEIKE ,  KLAPPACH KRISTIN ,  SCHNEIDER KARL-HEINRICH ,  SPROTE PETRA ,  HAGE KERSTIN ,  BLANZ BIRGIT ,  THINES ECKHARD ,  ANTELO LUIS ,  SANDJO LOUIS PERGAUD ,  OPATZ TILL

    IPC: C12N1/20

    Abstract: Abstract The present invention relates to novel isolated bacterial strains, which are members of the genus Paenbaci//us, originally isolated from soil and showing antagonistic activity 5 against a broad range of pathogens and being capable of producing antimicrobial metabo lites. It was found that the strains Lu16774 and Lu17007 belong to a novel subspecies named Paenibaci//uspo/ymyxa ssp. plantarum while the strain Lu17015 belongs to a novel species which is proposed to be Paenbac//us epphyticus. The present invention also relates to microbial pesticide compositions comprising at 10 least one of such novel bacterial strains, whole culture broth or a cell-free extract or a frac tion thereof or at least one metabolite thereof, and/or a mutant of at least one of said novel bacterial strains having all the identifying characteristics of the respective bacterial strain or whole culture broth, cell-free extract, fraction and/or metabolite of the mutant thereof showing antagonistic activity against plant pathogens. The present invention also relates to 15 a method of controlling or suppressing plant pathogens or preventing plant pathogen infec tions by applying such composition. The present invention also relates to novel fusaricidin type compounds which are metabolites produced by the strains of the present invention. 18398083_1 (GHMatters) P42612AU01

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