公开(公告)号：AU2007316718B2

公开(公告)日：2013-03-28

申请号：AU2007316718

申请日：2007-11-05

Applicant: BASF SE

Inventor： SUKOPP MARTIN ,  GRONING CARSTEN ,  LONGLET JON J ,  KUHN OLIVER ,  KEIL MICHAEL

IPC: C07D231/44 ,  A01N43/00 ,  A01N43/56 ,  A61K31/415 ,  A61P33/00

Abstract: The present invention relates to a process for the sulfinylation of a pyrazole derivative, characterized in that 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazole-3- carbonitrile (II) is reacted with a sulfinylating agent selected from trifluoromethylsulfinic acid, trifluoromethylsulfinic acid anhydride, and a trifluoromethylsulfinate alkaline or alkaline earth metal salt and mixtures of the acid and/or the salt(s), in the presence of at least one amine acid complex wherein the amine(s) are selected from tertiary amines and the acid(s) are selected from hydrofluoric, hydrochloric, hydrobromic and hydroiodic acid and sulfonic acid derivatives, and with the addition of a halogenating agent.

公开(公告)号：AU2007316721A1

公开(公告)日：2008-05-15

申请号：AU2007316721

申请日：2007-11-05

Applicant: BASF SE

Inventor： GRONING CARSTEN ,  SUKOPP MARTIN ,  KUHN OLIVER ,  KEIL MICHAEL ,  LONGLET JON J

IPC: C07D231/44 ,  A01N43/00 ,  A01N43/56 ,  A61K31/415 ,  A61P33/00

Abstract: The present invention relates to a process for the sulfinylation of a pyrazole derivative, characterized in that 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonitrile (II) is reacted with a sulfinylating agent S in the presence of at least one amine acid complex wherein the amine(s) are selected from secondary and/or tertiary amines and the acid(s) are selected from hydrofluoric, hydrochloric, hydrobromic and hydroiodic acid and sulfonic acid derivatives, and with the addition of a halogenating agent, wherein S is [CF3S(O)]2O; or CF3S(O)X wherein X means fluoro, chloro, bromo, iodo, a hydroxy group, or an alkaline or alkaline earth metal salt of the hydroxy group; or mixtures thereof, wherein the temperature of the reaction mixture at no time exceeds 39° C.

公开(公告)号：AU2007316718A1

公开(公告)日：2008-05-15

申请号：AU2007316718

申请日：2007-11-05

Applicant: BASF SE

Inventor： KUHN OLIVER ,  LONGLET JON J ,  SUKOPP MARTIN ,  KEIL MICHAEL ,  GRONING CARSTEN

IPC: C07D231/44 ,  A01N43/00 ,  A01N43/56 ,  A61K31/415 ,  A61P33/00

Abstract: The present invention relates to a process for the of a pyrazole derivative, characterized in that 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonitrile (II) is reacted with a sulfinylating agent selected from trifluoromethylsulfinic acid, trifluoromethylsulfinic acid anhydride, and a trifluoromethylsulfinate alkaline or alkaline earth metal salt and mixtures of the acid and/or the salt(s), in the presence of at least one amine acid complex wherein the amine(s) are selected from tertiary amines and the acid(s) are selected from hydrofluoric, hydrochloric, hydrobromic and hydroiodic acid and sulfonic acid derivatives, and with the addition of a halogenating agent.

公开(公告)号：AU2007316720B2

公开(公告)日：2013-05-09

申请号：AU2007316720

申请日：2007-11-05

Applicant: BASF SE

Inventor： GRONING CARSTEN ,  SUKOPP MARTIN ,  LONGLET JON J ,  KEIL MICHAEL ,  KUHN OLIVER

IPC: C07D231/44 ,  A01N43/00 ,  A01N43/56 ,  A61K31/415 ,  A61P33/00

Abstract: The present invention relates to a process for the sulfinylation of a pyrazole derivative, characterized in that 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonitrile (II) is reacted with a sulfinylating agent S in the presence of at least one amine acid complex wherein the amine(s) are selected from cyclic secondary amines and the acid(s) are selected from sulfonic acid derivatives, and with the addition of a halogenating agent, wherein S is [CF

公开(公告)号：NZ576594A

公开(公告)日：2011-12-22

申请号：NZ57659407

申请日：2007-11-05

Applicant: BASF SE

Inventor： SUKOPP MARTIN ,  KUHN OLIVER ,  KEIL MICHAEL ,  GRONING CARSTEN ,  LONGLET JON J

IPC: C07D231/44 ,  A01N43/00 ,  A01N43/56 ,  A61K31/415 ,  A61P33/00

Abstract: Disclosed is a process for the sulfinylation of a pyrazole derivative, characterized in that 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonitrile is reacted with a sulfinylating agent selected from trifluoromethylsulfinic acid, trifluoromethylsulfinic acid anhydride, and a trifluoromethylsulfinate alkaline or alkaline earth metal salt and mixtures of the acid and/or the salt(s), in the presence of at least one amine acid complex wherein the amine(s) are selected from tertiary amines and the acid(s) are selected from hydrofluoric acid, hydrochloric acid, p-toluenesulfonic acid, benzenesulfonic acid, xylene sulfonic acid, methanesulfonic acid and trifluoromethylsulfonic acid, and with the addition of a halogenating agent. Also disclosed is a method of treating animals against infestation or infection by parasites or protecting growing plants from infestation from insects, acarids or nematodes by applying or ingesting a 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(trifluoromethylsulfinyl)-pyrazole-3-carbonitrile prepared by the above process.

公开(公告)号：AU2007316720A1

公开(公告)日：2008-05-15

申请号：AU2007316720

申请日：2007-11-05

Applicant: BASF SE

Inventor： KEIL MICHAEL ,  KUHN OLIVER ,  LONGLET JON J ,  SUKOPP MARTIN ,  GRONING CARSTEN

IPC: C07D231/44 ,  A01N43/00 ,  A01N43/56 ,  A61K31/415 ,  A61P33/00

Abstract: The present invention relates to a process for the sulfinylation of a pyrazole derivative, characterized in that 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonitrile (II) is reacted with a sulfinylating agent S in the presence of at least one amine acid complex wherein the amine(s) are selected from cyclic secondary amines and the acid(s) are selected from sulfonic acid derivatives, and with the addition of a halogenating agent, wherein S is [CF3S(O)]2O; or CF3S(O)X wherein X means fluoro, chloro, bromo, iodo, a hydroxy group, or an alkaline or alkaline earth metal salt of the hydroxy group; or mixtures thereof.

公开(公告)号：AU2007316721B2

公开(公告)日：2013-05-09

申请号：AU2007316721

申请日：2007-11-05

Applicant: BASF SE

Inventor： LONGLET JON J ,  KUHN OLIVER ,  GRONING CARSTEN ,  KEIL MICHAEL ,  SUKOPP MARTIN

IPC: C07D231/44 ,  A01N43/00 ,  A01N43/56 ,  A61K31/415 ,  A61P33/00

Abstract: The present invention relates to a process for the sulfinylation of a pyrazole derivative, characterized in that 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonitrile (II) is reacted with a sulfinylating agent S in the presence of at least one amine acid complex wherein the amine(s) are selected from secondary and/or tertiary amines and the acid(s) are selected from hydrofluoric, hydrochloric, hydrobromic and hydroiodic acid and sulfonic acid derivatives, and with the addition of a halogenating agent, wherein S is [CF

公开(公告)号：UA98474C2

公开(公告)日：2012-05-25

申请号：UAA200905381

申请日：2007-11-05

Applicant: BASF SE

Inventor： SUKOPP MARTIN ,  KUHN OLIVER ,  GRONING CARSTEN ,  KEIL MICHAEL ,  LONGLET JON J

IPC: C07D231/44 ,  A01N43/56 ,  A61K31/415 ,  A61P33/00

Abstract: Данноеизобретениекасаетсяновогоспособасульфинированияпроизводнойпиразола, вкотором 5-амино-1-[2,6-дихлор-4-(трифторметил)фенил]-1Н-пиразол-3-карбонитрил (II) подвергаютреакциис сульфинирующимагентом, выбраннымизтрифторметилсульфиновойкислоты, ангидридатрифторметилсульфиновойкислоты, солитрифторметилсульфинатащелочногоилищелочноземельногометаллаи смесейкислотыи/илисоли(ей), вприсутствиипокрайнеймереодногоамино/ кислотногокомплекса, гдеамин(ы) выбран(ы) изтретичныхаминов, акислота(ы) выбрана(ы) изфтористоводородной, хлористоводородной, бромистоводородной, йодистоводороднойкислоти производныхсульфоновойкислоты, сдобавлениемгалогенирующегоагента.

公开(公告)号：EA016304B1

公开(公告)日：2012-04-30

申请号：EA200900628

申请日：2007-11-05

Applicant: BASF SE

Inventor： SUKOPP MARTIN ,  KUHN OLIVER ,  GRONING CARSTEN ,  KEIL MICHAEL ,  LONGLET JON J

IPC: C07D231/44 ,  A01N43/00 ,  A01N43/56 ,  A61K31/415 ,  A61P33/00

Abstract: Настоящееизобретениеотноситсяк новомуспособусульфинилированияпроизводнойпиразола, характеризующемусятем, что 5-амино-1-[2,6-дихлор-4-(трифторметил)фенил]-1H-пиразол-3-карбонитрил (II) подвергаютреакциис сульфинилирующимагентом S вприсутствиипокрайнеймереодногоамино/кислотногокомплекса, вкоторомамин(ы) является(ются) выбранным(и) извторичныхи/илитретичныхаминов, акислота(ы) является(являются) выбранной(ыми) изфтористо-водородной, хлористо-водородной, бромисто-водороднойи йодисто-водороднойкислоти производныхсульфоновойкислоты, придобавлениигалогенирующегоагента, где S представляетсобой [CFS(O)]O или CFS(O)X, где X означаетфтор, хлор, бром, йод, гидроксигруппуилисольщелочногоилищелочно-земельногометаллагидроксигруппы; илиихсмеси, гдетемпературареакционнойсмесиникогданепревышает 39°C.

公开(公告)号：ZA200903968B

公开(公告)日：2012-02-29

申请号：ZA200903968

申请日：2009-06-08

Applicant: BASF SE

Inventor： SUKOPP MARTIN ,  KEIL MICHAEL ,  LONGLET JON J ,  KUHN OLIVER ,  GRONING CARSTEN

IPC: C07D20060101 ,  A01N20060101 ,  A61K20060101 ,  A61P20060101

Abstract: The present invention relates to a process for the of a pyrazole derivative, characterized in that 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonitrile (II) is reacted with a sulfinylating agent selected from trifluoromethylsulfinic acid, trifluoromethylsulfinic acid anhydride, and a trifluoromethylsulfinate alkaline or alkaline earth metal salt and mixtures of the acid and/or the salt(s), in the presence of at least one amine acid complex wherein the amine(s) are selected from tertiary amines and the acid(s) are selected from hydrofluoric, hydrochloric, hydrobromic and hydroiodic acid and sulfonic acid derivatives, and with the addition of a halogenating agent.