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    METHOD FOR THE PRODUCTION OF HALOGEN-SUBSTITUTED 2-(AMINOMETHYLIDENE)-3- OXOBUTYRIC ACID ESTERS
    3.
    发明申请
    METHOD FOR THE PRODUCTION OF HALOGEN-SUBSTITUTED 2-(AMINOMETHYLIDENE)-3- OXOBUTYRIC ACID ESTERS 审中-公开
    用于生产方法卤素取代的2-（氨基亚甲基）-3-氧代丁酸

    公开(公告)号：WO2009133179A3

    公开(公告)日：2010-02-25

    申请号：PCT/EP2009055285

    申请日：2009-04-30

    Applicant: BASF SE ,  ZIERKE THOMAS ,  MAYWALD VOLKER ,  RACK MICHAEL ,  SMIDT SEBASTIAN PEER ,  KEIL MICHAEL ,  WOLF BERND ,  KORADIN CHRISTOPHER

    Inventor： ZIERKE THOMAS ,  MAYWALD VOLKER ,  RACK MICHAEL ,  SMIDT SEBASTIAN PEER ,  KEIL MICHAEL ,  WOLF BERND ,  KORADIN CHRISTOPHER

    IPC: C07D231/14 ,  C07D295/145

    CPC classification number: C07D295/145 ,  C07D231/14

    Abstract: The present invention relates to a method for producing 2- (aminomethylidene)-4,4dihalo-3-oxobutyric acid esters of the formula (I), where R1, R2, R3 are C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C3-C10-cycloalkyl or benzyl and/or R2 together with R3 and the nitrogen atom, to which both radicals are bound, are a heterocyclic radical, wherein a corresponding 3-aminoacrylic acid ester is reacted with a halogen-substituted acetyl fluoride in the presence of at least one alkali or earth alkali metal fluoride. The invention also relates to the further reaction of halogen-substituted 2-(aminomethylidene)-3-oxobutyric acid esters of the formula (1) into halomethyl-substituted pyrazole-4-ylcarboxylic acids and the esters thereof.

    Abstract translation: 本发明涉及2-（氨基 - 亚甲基）的制备方法中，式-4,4-二卤代-3-氧代丁酸酯（I）其中R1，R2，R3是C1-C6烷基，C1-C6卤代烷基 ，C2-C6链烯基，C3-C10环烷基或与R 3苄基和/或R 2在一起并到两个基团连接的氮原子代表的杂环基团，其中一个相应的3-氨基丙烯酸酯是具有 卤乙酰氟取代反应是在至少一种碱金属或碱土金属氟化物的存在; 和卤素 - 取代的2-（氨基亚甲基）-3-氧代丁酸的式（I）的酯的进一步反应卤代甲基取代的吡唑-4-基甲酸和它们的酯。

    PROCESS FOR PREPARING SUBSTITUTED PHENYLHYDRAZINES
    5.
    发明申请
    PROCESS FOR PREPARING SUBSTITUTED PHENYLHYDRAZINES 审中-公开
    制备取代苯乙烯的方法

    公开(公告)号：WO2008113661A3

    公开(公告)日：2008-12-04

    申请号：PCT/EP2008052346

    申请日：2008-02-27

    Applicant: BASF SE ,  ZIERKE THOMAS ,  RACK MICHAEL

    Inventor： ZIERKE THOMAS ,  RACK MICHAEL

    IPC: C07C241/02

    CPC classification number: C07C319/20 ,  C07C241/02 ,  C07C323/48 ,  C07C243/22

    Abstract: This invention relates to a process for preparing substituted phenylhydrazines of the formula I wherein R has the meaning as indicated in the description, comprising reacting a dichlorofluorobenzene of the formula Il with a hydrazine source selected from hydrazine, hydrazine hydrate and acid addition salts of hydrazine and optionally being carried out in the presence of at least one organic solvent.

    Abstract translation: 本发明涉及一种制备式I取代苯肼的方法，其中R具有如说明书中所述的含义，包括使式II的二氯氟苯与选自肼，水合肼和肼的酸加成盐的肼源和 任选地在至少一种有机溶剂的存在下进行。

    METHOD FOR PREPARING 1,3,4-SUBSTITUTED PYRAZOL COMPOUNDS
    6.
    发明申请
    METHOD FOR PREPARING 1,3,4-SUBSTITUTED PYRAZOL COMPOUNDS 审中-公开
    用于生产取代1,3,4-吡唑

    公开(公告)号：WO2009135808A2

    公开(公告)日：2009-11-12

    申请号：PCT/EP2009055328

    申请日：2009-05-04

    Applicant: BASF SE ,  WOLF BERND ,  MAYWALD VOLKER ,  KEIL MICHAEL ,  KORADIN CHRISTOPHER ,  RACK MICHAEL ,  ZIERKE THOMAS ,  SUKOPP MARTIN

    Inventor： WOLF BERND ,  MAYWALD VOLKER ,  KEIL MICHAEL ,  KORADIN CHRISTOPHER ,  RACK MICHAEL ,  ZIERKE THOMAS ,  SUKOPP MARTIN

    IPC: C07D231/14

    CPC classification number: C07D409/12 ,  C07C251/76 ,  C07C251/84 ,  C07C251/86 ,  C07D231/14

    Abstract: The present invention relates to a method for preparing 1,3-substituted pyrazol compounds of formula (I), where X stands for a group CX1X2X3, with X1, X2 and X3 being hydrogen, fluorine or chlorine, independently of one another, R1 being an C1-C4 alkyl or cyclopropyl, and R2 being hydrogen, CN or a group CO2R2a, where R2a stands for C1-C6 alkyl in particular, comprising the following steps: i) reacting a compound of formula II with a hydrazone of formula (III), wherein in formula (II) the variables X and R2 have the same meaning as indicated for formula (I), Y stands for oxygen, a group NRy1 or a group [NRy2Ry3]+Z- , R3 stands for OR3a or a group NR3bR3c, and wherein in formula (III) the variable R1 has the same meaning as indicated for formula (I), R4 and R5 stand for hydrogen, C1-C6 alkyl, alternatively substituted phenyl, independent of one another, wherein at least one of the radicals R4 or R5 is different from hydrogen and where R4 and R5 can also stand for a 5 to 10-membered saturated carbocycle together with the carbon atom connected thereto; treatment of the reaction product obtained thereby with an acid in the presence of water.

    Abstract translation: 本发明涉及一种方法，用于制备1,3-取代的式（I），其中X是特别的一组CX1X2X3，其中X1，X2和X3独立地为特别是氢，氟或氯的吡唑化合物中，R1是C1 〜C 4烷基或环丙基，和R 2是氢，CN或基团CO2R2a，其中R 2a是特别C1-C6烷基，所述方法包括以下步骤：i）将式II的化合物与下式的腙反应 （III）其中在式（II）中，变量，X和R 2具有对式（I）所给出的含义，Y是氧，一组或一组NRy1 [NRy2Ry3] + Z-，R 3表示OR3a或一组NR3bR3c ，并且其中，在式（III）中，变量R1具有式（I）中给出的含义，R4和R5独立地是氢，C1-C6烷基，其任选被取代的苯基，其中至少一个基团 ëR4或R5是不同于氢，并且其中可以与它们所连接为一个5至10元饱和碳环，R4和R5的碳原子一起; 在水存在下用酸处理所得到的反应产物。

    METHOD FOR PRODUCING DIFLUOROMETHYL-SUBSTITUTED PYRAZOLE COMPOUNDS
    7.
    发明申请
    METHOD FOR PRODUCING DIFLUOROMETHYL-SUBSTITUTED PYRAZOLE COMPOUNDS 审中-公开
    用于生产二氟吡唑

    公开(公告)号：WO2008152138A3

    公开(公告)日：2009-05-28

    申请号：PCT/EP2008057506

    申请日：2008-06-13

    Applicant: BASF SE ,  NETT MARKUS ,  GROTE THOMAS ,  LOHMANN JAN KLAAS ,  DIETZ JOCHEN ,  SMIDT SEBASTIAN PEER ,  RACK MICHAEL ,  ZIERKE THOMAS

    Inventor： NETT MARKUS ,  GROTE THOMAS ,  LOHMANN JAN KLAAS ,  DIETZ JOCHEN ,  SMIDT SEBASTIAN PEER ,  RACK MICHAEL ,  ZIERKE THOMAS

    IPC: C07D231/12 ,  C07D231/14

    CPC classification number: C07D231/12 ,  C07D231/14

    Abstract: The invention relates to a method for producing 3-difluoromethyl-substituted pyrazole compounds of formula (I), wherein R1 represents H, halogen, nitro, C1-C8 alkyl, C1-C8 haloalkyl, C3-C8 cycloalkyl, phenyl, naphthyl, hetaryl, cyano, -C(=O)-OR1a, -C(=O)-NR1bR1c, -C(=O)-SR1d or -C(=S)-SR1 e; R2 represents H, C1-C4 alkyl, benzyl or phenyl; R3 represents H, halogen, C1-C8 alkoxy, C1-C8 haloalkoxy, C3-C8 cycloalkoxy, C2-C8 alkenyloxy, C1-C8 alkylthio, C1-C8 haloalkylthio, C3-C8 cycloalkylthio or C2-C8 alkenylthio; to compounds of formula (II.a) or (II.b), wherein R1 and R3 have one of the above definitions; R4 represents halogen, -OR4a, -SR4a , -O-SO2-R4a or a group -NR4bR4c; R5 and R6 represent C1-C8 alkyl, C1-C8 haloalkyl, C3-C8 cycloalkyl, benzyl or phenyl or together with the nitrogen atom to which they are bound represent a 3- to 8-membered heterocycle; to Lewis acid adducts of compounds of formula (II.b); to the use of compounds of formula (II.a) or (II.b) and of the Lewis acid adducts thereof for producing compounds of formula (I) or (VI); and to a method for converting said compounds to the corresponding 3-difluoromethylpyrazole-4-yl carboxylic acids.

    Abstract translation: 本发明涉及一种用于制备式-3-二氟甲基吡唑（I）化合物其中R1是H，卤素，硝基，C1-C8烷基，C1-C8卤代烷基，C3-C8环烷基，苯基，萘基，杂芳基， 氰基，-C（= O）-OR1a，-C（= O）-NR1bR1c，-C（= O）-SR1d或-C（= S）-SR1e基; R2是H，C1-C4烷基，苄基或苯基; R 3为H，卤素，C1-C8烷氧基，C1-C8卤代烷氧基，C3-C8环烷氧基，C2-C8链烯氧基，C1-C8烷硫基，C1-C8卤代烷硫基，C3-C8-环烷硫基或C 2 -C C8-烯硫基;式（二.a）或（二.b）的化合物，其中R 1和R 3具有以上给出的含义之一; R 4是卤素，-OR4a，-SR4a，-O-SO2-R4A或一组-NR4bR4c基; R5和R6是C1-C8烷基，C1-C8卤代烷基，C3-C8环烷基，苄基或苯基或一起与氮原子到它们所键合的，代表3-至8-元杂环; 式（二.b）化合物的路易斯酸加合物;使用（二.a）或（二.b）和路易斯酸加合物，式I化合物的对式（I）或（VI）的化合物的制备方法; 并且这些化合物转变成相应的3-二氟甲基吡唑-4-基甲磺酸的方法。

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