公开(公告)号：WO2015030885A1

公开(公告)日：2015-03-05

申请号：PCT/US2014/039212

申请日：2014-05-22

Applicant: BATTELLE MEMORIAL INSTITUTE

Inventor： WEBB, Ian K. ,  TANG, Keqi ,  SMITH, Richard D. ,  IBRAHIM, Yehia M. ,  ANDERSON, Gordon A.

IPC: H01J49/00 ,  H01J49/06

CPC classification number: H01J49/063 ,  H01J49/0063

Abstract: A method of dissociating ions in a multipole ion guide is disclosed. A stream of charged ions is supplied to the ion guide. A main RF field is applied to the ion guide to confine the ions through the ion guide. An excitation RF field is applied to one pair of rods of the ion guide. The ions undergo dissociation when the applied excitation RF field is resonant with a secular frequency of the ions. The multipole ion guide is, but not limited to, a quadrupole, a hexapole, and an octopole.

Abstract translation: 公开了一种在多极离子导向器中离解离子的方法。 将带电离子流供给到离子导向器。 将主RF场施加到离子导向器以将离子限制在离子导向器上。 激发RF场被施加到离子导向器的一对杆上。 当施加的激发RF场与离子的长期频率共振时，离子发生解离。 多极离子导向器是但不限于四极，六极和八极。

公开(公告)号：WO2016069104A1

公开(公告)日：2016-05-06

申请号：PCT/US2015/048038

申请日：2015-09-02

Applicant: BATTELLE MEMORIAL INSTITUTE

Inventor： TOLMACHEV, Aleksey V. ,  SMITH, Richard D. ,  IBRAHIM, Yehia M. ,  ANDERSON, Gordon A. ,  BAKER, Erin M.

IPC: H01J49/06

CPC classification number: H01J49/062

Abstract: An ion manipulation method and device to prevent loss of ions is disclosed. The device includes a pair of surfaces. An inner array of electrodes is coupled to the surfaces. A RF voltage and a DC voltage are alternately applied to the inner array of electrodes. The applied RF voltage is alternately positive and negative so that immediately adjacent or nearest neighbor RF applied electrodes are supplied with RF signals that are approximately 180 degrees out of phase.

Abstract translation: 公开了一种用于防止离子损失的离子操作方法和装置。 该装置包括一对表面。 电极的内部阵列耦合到表面。 RF电压和DC电压交替施加到电极的内部阵列。 施加的RF电压交替地是正的和负的，使得紧邻或最近邻RF施加的电极被提供有大约相差180度的RF信号。

公开(公告)号：WO2012141771A1

公开(公告)日：2012-10-18

申请号：PCT/US2012/021338

申请日：2012-01-13

Applicant: BATTELLE MEMORIAL INSTITUTE ,  SHVARTSBURG, Alexandre A. ,  ANDERSON, Gordon A. ,  SMITH, Richard D.

Inventor： SHVARTSBURG, Alexandre A. ,  ANDERSON, Gordon A. ,  SMITH, Richard D.

IPC: H01J49/00 ,  H01J49/06

CPC classification number: H01J49/0018 ,  H01J49/066

Abstract: Electrodynamic ion funnels confine, guide, or focus ions in gases using the Dehmelt potential of oscillatory electric field. New funnel designs operating at or close to atmospheric gas pressure are described. Effective ion focusing at such pressures is enabled by fields of extreme amplitude and frequency, allowed in microscopic gaps that have much higher electrical breakdown thresholds in any gas than the macroscopic gaps of present funnels. The new microscopic-gap funnels are useful for interfacing atmospheric-pressure ionization sources to mass spectrometry (MS) and ion mobility separation (IMS) stages including differential IMS or FAIMS, as well as IMS and MS stages in various configurations. In particular, "wedge" funnels comprising two planar surfaces positioned at an angle and wedge funnel traps derived therefrom can compress ion beams in one dimension, producing narrow belt-shaped beams and laterally elongated cuboid packets. This beam profile reduces the ion density and thus space-charge effects, mitigating the adverse impact thereof on the resolving power, measurement accuracy, and dynamic range of MS and IMS analyzers, while a greater overlap with coplanar light or particle beams can benefit spectroscopic methods.

Abstract translation: 电动离子漏斗使用振荡电场的Dehmelt电位限制，引导或聚焦气体中的离子。 描述了处于或接近大气压力的新漏斗设计。 在这种压力下的有效离子聚焦是通过极大幅度和频率的场来实现的，微观间隙允许在任何气体中具有比当前漏斗的宏观间隙高得多的电击穿阈值。 新的微间隙漏斗可用于将大气压电离源与包括差分IMS或FAIMS的质谱（MS）和离子迁移率分离（IMS）阶段以及各种配置的IMS和MS阶段进行接口。 特别地，包括两个平坦的表面定位成角度的楔形漏斗和从其衍生的楔形漏斗捕获器可以在一个维度上压缩离子束，产生窄的带状波束和横向延伸的立方体分组。 这种光束轮廓降低了离子密度，从而降低了空间电荷效应，减轻了MS和IMS分析仪的分辨率，测量精度和动态范围的不利影响，而与共面光或粒子束的更大重叠可有利于光谱方法 。

公开(公告)号：WO2021072371A2

公开(公告)日：2021-04-15

申请号：PCT/US2020/055247

申请日：2020-10-12

Applicant: BATTELLE MEMORIAL INSTITUTE ,  CLEMSON UNIVERSITY RESEARCH FOUNDATON ,  GAA CUSTOM ENGINEERING, LLC

Inventor： KOPPENAAL, David W. ,  ZHU, Ying ,  HOEGG, Edward D. ,  MARCUS, R. Kenneth ,  ANDERSON, Gordon A. ,  ANDERSON, Chris ,  WILLIAMS, Tyler

IPC: H01J49/16

Abstract: Apparatus include an atmospheric pressure glow discharge (APGD) analyte electrode defining an analyte discharge axis into an APGD volume, and a plurality of APGD counter electrodes having respective electrical discharge ends directed to the APGD volume, wherein the APGD analyte electrode and the APGD counter electrodes are configured to produce an APGD plasma in the APGD volume with a voltage difference between the APGD analyte electrode and one or more of the AGPD counter electrodes. An electrode can be integrated into an ion inlet. Apparatus can be configured to perform auto-ignition and/or provide multi-modal operation through selectively powering electrodes. Electrode holder devices are disclosed. Related methods are disclosed.

公开(公告)号：WO2014168660A1

公开(公告)日：2014-10-16

申请号：PCT/US2014/011291

申请日：2014-01-13

Applicant: BATTELLE MEMORIAL INSTITUTE

Inventor： ANDERSON, Gordon A. ,  SMITH, Richard D. ,  IBRAHIM, Yehia M. ,  BAKER, Erin M.

IPC: H01J49/00 ,  H01J49/04 ,  H01J49/40

CPC classification number: H01J49/062 ,  G01N27/622 ,  H01J49/06

Abstract: An ion manipulation method and device is disclosed. The device includes a pair of substantially parallel surfaces. An array of inner electrodes is contained within, and extends substantially along the length of, each parallel surface. The device includes a first outer array of electrodes and a second outer array of electrodes. Each outer array of electrodes is positioned on either side of the inner electrodes, and is contained within and extends substantially along the length of each parallel surface. A DC voltage is applied to the first and second outer array of electrodes. A RF voltage, with a superimposed electric field, is applied to the inner electrodes by applying the DC voltages to each electrode. Ions either move between the parallel surfaces within an ion confinement area or along paths in the direction of the electric field, or can be trapped in the ion confinement area.

Abstract translation: 公开了一种离子操作方法和装置。 该装置包括一对基本平行的表面。 内部电极的阵列包含在每个平行表面内并且基本上沿着每个平行表面的长度延伸。 该装置包括电极的第一外部阵列和第二外部电极阵列。 每个外部电极阵列位于内部电极的任一侧上，并且基本上沿着每个平行表面的长度容纳并延伸。 DC电压施加到第一和第二外部电极阵列。 通过向每个电极施加直流电压，将具有叠加电场的RF电压施加到内部电极。 离子在离子限制区域内的平行表面之间或沿着电场方向的路径移动，或者可以被捕获在离子限制区域中。

公开(公告)号：EP2697818A1

公开(公告)日：2014-02-19

申请号：EP12702352.1

申请日：2012-01-13

Applicant: Battelle Memorial Institute

Inventor： SHVARTSBURG, Alexandre A. ,  ANDERSON, Gordon A. ,  SMITH, Richard D.

IPC: H01J49/00 ,  H01J49/06

CPC classification number: H01J49/0018 ,  H01J49/066

Abstract: Electrodynamic ion funnels confine, guide, or focus ions in gases using the Dehmelt potential of oscillatory electric field. New funnel designs operating at or close to atmospheric gas pressure are described. Effective ion focusing at such pressures is enabled by fields of extreme amplitude and frequency, allowed in microscopic gaps that have much higher electrical breakdown thresholds in any gas than the macroscopic gaps of present funnels. The new microscopic-gap funnels are useful for interfacing atmospheric-pressure ionization sources to mass spectrometry (MS) and ion mobility separation (IMS) stages including differential IMS or FAIMS, as well as IMS and MS stages in various configurations. In particular, "wedge" funnels comprising two planar surfaces positioned at an angle and wedge funnel traps derived therefrom can compress ion beams in one dimension, producing narrow belt-shaped beams and laterally elongated cuboid packets. This beam profile reduces the ion density and thus space-charge effects, mitigating the adverse impact thereof on the resolving power, measurement accuracy, and dynamic range of MS and IMS analyzers, while a greater overlap with coplanar light or particle beams can benefit spectroscopic methods.

Abstract translation: 电动离子漏斗利用振荡电场的Dehmelt电势来限制，引导或集中离子在气体中。 描述了以大气压力或接近大气压力运行的新漏斗设计。 在这样的压力下有效的离子聚焦通过极大幅度和频率的场来实现，允许在任何气体中具有比当前漏斗的宏观间隙高得多的电击穿阈值的微观间隙。 新的微观漏斗可用于将大气压电离源连接到质谱（MS）和离子迁移分离（IMS）阶段，包括差异IMS或FAIMS，以及各种配置中的IMS和MS阶段。 具体地说，包括以一定角度定位的两个平面表面和由其衍生的楔形漏斗陷阱的“楔形”漏斗可以在一个维度上压缩离子束，从而产生窄的带形梁和横向伸长的长方体包。 该光束轮廓降低了离子密度和空间电荷效应，减轻了其对MS和IMS分析仪的分辨能力，测量精度和动态范围的不利影响，而与共面光或粒子束更大的重叠可以有利于光谱方法 。

公开(公告)号：EP2984675A1

公开(公告)日：2016-02-17

申请号：EP14782685.3

申请日：2014-01-13

Applicant: Battelle Memorial Institute

Inventor： ANDERSON, Gordon A. ,  SMITH, Richard D. ,  IBRAHIM, Yehia M. ,  BAKER, Erin M.

IPC: H01J49/00 ,  H01J49/04 ,  H01J49/40

CPC classification number: H01J49/062 ,  G01N27/622 ,  H01J49/06

Abstract: An ion manipulation method and device is disclosed. The device includes a pair of substantially parallel surfaces. An array of inner electrodes is contained within, and extends substantially along the length of, each parallel surface. The device includes a first outer array of electrodes and a second outer array of electrodes. Each outer array of electrodes is positioned on either side of the inner electrodes, and is contained within and extends substantially along the length of each parallel surface. A DC voltage is applied to the first and second outer array of electrodes. A RF voltage, with a superimposed electric field, is applied to the inner electrodes by applying the DC voltages to each electrode. Ions either move between the parallel surfaces within an ion confinement area or along paths in the direction of the electric field, or can be trapped in the ion confinement area.