公开(公告)号：WO2014168660A1

公开(公告)日：2014-10-16

申请号：PCT/US2014/011291

申请日：2014-01-13

Applicant: BATTELLE MEMORIAL INSTITUTE

Inventor： ANDERSON, Gordon A. ,  SMITH, Richard D. ,  IBRAHIM, Yehia M. ,  BAKER, Erin M.

IPC: H01J49/00 ,  H01J49/04 ,  H01J49/40

CPC classification number: H01J49/062 ,  G01N27/622 ,  H01J49/06

Abstract: An ion manipulation method and device is disclosed. The device includes a pair of substantially parallel surfaces. An array of inner electrodes is contained within, and extends substantially along the length of, each parallel surface. The device includes a first outer array of electrodes and a second outer array of electrodes. Each outer array of electrodes is positioned on either side of the inner electrodes, and is contained within and extends substantially along the length of each parallel surface. A DC voltage is applied to the first and second outer array of electrodes. A RF voltage, with a superimposed electric field, is applied to the inner electrodes by applying the DC voltages to each electrode. Ions either move between the parallel surfaces within an ion confinement area or along paths in the direction of the electric field, or can be trapped in the ion confinement area.

Abstract translation: 公开了一种离子操作方法和装置。 该装置包括一对基本平行的表面。 内部电极的阵列包含在每个平行表面内并且基本上沿着每个平行表面的长度延伸。 该装置包括电极的第一外部阵列和第二外部电极阵列。 每个外部电极阵列位于内部电极的任一侧上，并且基本上沿着每个平行表面的长度容纳并延伸。 DC电压施加到第一和第二外部电极阵列。 通过向每个电极施加直流电压，将具有叠加电场的RF电压施加到内部电极。 离子在离子限制区域内的平行表面之间或沿着电场方向的路径移动，或者可以被捕获在离子限制区域中。

公开(公告)号：WO2015191683A1

公开(公告)日：2015-12-17

申请号：PCT/US2015/035059

申请日：2015-06-10

Applicant: BATTELLE MEMORIAL INSTITUTE

Inventor： IBRAHIM, Yehia M. ,  CHEN, Tsung-Chi ,  HARRER, Marques B. ,  TANG, Keqi ,  SMITH, Richard D.

IPC: H01J49/06 ,  G01N27/62

CPC classification number: H01J49/066

Abstract: An ion funnel device is disclosed. A first pair of electrodes is positioned in a first direction. A second pair of electrodes is positioned in a second direction. The device includes an RF voltage source and a DC voltage source. A RF voltage with a superimposed DC voltage gradient is applied to the first pair of electrodes, and a DC voltage gradient is applied to the second pair of electrodes.

Abstract translation: 公开了一种离子漏斗装置。 第一对电极位于第一方向。 第二对电极位于第二方向。 该器件包括一个RF电压源和一个直流电压源。 将具有叠加的DC电压梯度的RF电压施加到第一对电极，并且将直流电压梯度施加到第二对电极。

公开(公告)号：WO2012050642A3

公开(公告)日：2012-04-19

申请号：PCT/US2011/041032

申请日：2011-06-20

Applicant: BATTELLE MEMORIAL INSTITUTE ,  SUN, Xuefei ,  KELLY, Ryan T. ,  TANG, Keqi ,  SMITH, Richard D.

Inventor： SUN, Xuefei ,  KELLY, Ryan T. ,  TANG, Keqi ,  SMITH, Richard D.

IPC: G01N27/26 ,  G01N27/447 ,  G01N35/10

Abstract: Microchip capillary electrophoresis (CE) utilizing a sample injector based on a mechanical valve rather than electrokinetic injection can provide improved sample injections, enhanced capabilities, and can eliminate the need for changing the electric field in the separation channel to induce sample injection. In one instance CE electrodes continuously apply an electric field for CE separation along a separation channel. A sample channel is connected to the separation channel at an intersection and has a sample pressure that is greater than that which is present in the separation channel near the intersection. The sample channel does not have electrodes that apply voltages for electrokinetic injection. A sample injector in the sample channel or at the intersection comprises a mechanical valve to control sample injection from the sample channel to the separation channel.

公开(公告)号：WO2017044159A1

公开(公告)日：2017-03-16

申请号：PCT/US2016/030455

申请日：2016-05-02

Applicant: BATTELLE MEMORIAL INSTITUTE

Inventor： IBRAHIM, Yehia M. ,  GARIMELLA, Sandilya V. B. ,  SMITH, Richard D.

IPC: H01J49/02 ,  H01J49/00 ,  G01N27/62

CPC classification number: H01J49/26 ,  G01N27/622 ,  H01J49/0013 ,  H01J49/022 ,  H01J49/40

Abstract: Methods and devices for ion separations or manipulations in gas phase are disclosed. The device includes a single non-planar surface. Arrays of electrodes are coupled to the surface. A combination of RF and DC voltages are applied to the arrays of electrodes to create confining and driving fields that move ions through the device. The DC voltages are static DC voltages or time-dependent DC potentials or waveforms.

Abstract translation: 公开了用于气相中离子分离或操作的方法和装置。 该装置包括单个非平面表面。 电极阵列耦合到表面。 将RF和DC电压的组合施加到电极阵列以产生将离子移动通过器件的限制和驱动场。 直流电压是静态直流电压或时间依赖直流电位或波形。

公开(公告)号：WO2015160427A1

公开(公告)日：2015-10-22

申请号：PCT/US2015/016402

申请日：2015-02-18

Applicant: BATTELLE MEMORIAL INSTITUTE

Inventor： IBRAHIM, Yehia M. ,  SMITH, Richard D.

IPC: H01J49/06

CPC classification number: H01J49/066 ,  H01J49/06 ,  H01J49/062 ,  H01J49/063 ,  H01J49/065

Abstract: A device for separating non-ions from ions is disclosed. The device includes a plurality of electrodes positioned around a center axis of the device and having apertures therein through which the ions are transmitted. An inner diameter of the apertures varies in length. At least a portion of the center axis between the electrodes is non-linear.

Abstract translation: 公开了一种用于从离子离子分离的装置。 该装置包括围绕该装置的中心轴定位的多个电极，并且其中具有孔，离子通过该孔传输。 孔径的内径长度变化。 电极之间的中心轴的至少一部分是非线性的。

公开(公告)号：WO2019125891A1

公开(公告)日：2019-06-27

申请号：PCT/US2018/065380

申请日：2018-12-13

Applicant: BATTELLE MEMORIAL INSTITUTE

Inventor： IBRAHIM, Yehia M. ,  SMITH, Richard D.

IPC: H01J49/06

CPC classification number: H01J37/3171 ,  H01J37/05 ,  H01J37/08 ,  H01J37/21 ,  H01J49/062 ,  H01J49/065 ,  H01J2237/049 ,  H01J2237/30472

Abstract: Apparatus includes a plurality of electrode arrangements spaced apart from each other opposite an ion propagation axis and defining an ion transfer channel that extends along the ion propagation axis that tapers between an input end that is situated to receive ions and an output end that is situated to couple the received ions to an input end of an ion guide. Methods include positioning a plurality of electrode arrangements at oblique angles opposite an ion propagation axis so as to form an ion transfer channel that tapers between an input end and an output end, and coupling the output end of the ion transfer channel to an input end of an ion optical element so as to direct ions in the ion transfer channel into the ion optical element. RF voltages are applied for confining the ions. Travelling waves are generated along the ion propagation axis.

公开(公告)号：WO2015030885A1

公开(公告)日：2015-03-05

申请号：PCT/US2014/039212

申请日：2014-05-22

Applicant: BATTELLE MEMORIAL INSTITUTE

Inventor： WEBB, Ian K. ,  TANG, Keqi ,  SMITH, Richard D. ,  IBRAHIM, Yehia M. ,  ANDERSON, Gordon A.

IPC: H01J49/00 ,  H01J49/06

CPC classification number: H01J49/063 ,  H01J49/0063

Abstract: A method of dissociating ions in a multipole ion guide is disclosed. A stream of charged ions is supplied to the ion guide. A main RF field is applied to the ion guide to confine the ions through the ion guide. An excitation RF field is applied to one pair of rods of the ion guide. The ions undergo dissociation when the applied excitation RF field is resonant with a secular frequency of the ions. The multipole ion guide is, but not limited to, a quadrupole, a hexapole, and an octopole.

Abstract translation: 公开了一种在多极离子导向器中离解离子的方法。 将带电离子流供给到离子导向器。 将主RF场施加到离子导向器以将离子限制在离子导向器上。 激发RF场被施加到离子导向器的一对杆上。 当施加的激发RF场与离子的长期频率共振时，离子发生解离。 多极离子导向器是但不限于四极，六极和八极。

公开(公告)号：WO2014137398A1

公开(公告)日：2014-09-12

申请号：PCT/US2013/064011

申请日：2013-10-09

Applicant: BATTELLE MEMORIAL INSTITUTE ,  UNIVERSITY OF MARYLAND

Inventor： WANG, Chenchen ,  TANG, Keqi ,  SMITH, Richard D.

IPC: H01J49/16 ,  G01N27/447 ,  G01N30/72

CPC classification number: H01J49/167 ,  G01N27/44713 ,  G01N30/7266

Abstract: A sheathless interface for coupling capillary electrophoresis (CE) with mass spectrometry is disclosed. The sheathless interface includes a separation capillary for performing CE separation and an emitter capillary for electrospray ionization. A portion of the emitter capillary is porous or, alternatively, is coated to form an electrically conductive surface. A section of the emitter capillary is disposed within the separation capillary, forming a joint. A metal tube, containing a conductive liquid, encloses the joint.

Abstract translation: 公开了一种用于耦合毛细管电泳（CE）和质谱的无鞘界面。 无鞘界面包括用于进行CE分离的分离毛细管和用于电喷雾离子化的发射体毛细管。 发射管毛细管的一部分是多孔的，或者替代地，被涂覆以形成导电表面。 发射管毛细管的一部分设置在分离毛细管内，形成接头。 包含导电液体的金属管封闭接头。

公开(公告)号：WO2016069104A1

公开(公告)日：2016-05-06

申请号：PCT/US2015/048038

申请日：2015-09-02

Applicant: BATTELLE MEMORIAL INSTITUTE

Inventor： TOLMACHEV, Aleksey V. ,  SMITH, Richard D. ,  IBRAHIM, Yehia M. ,  ANDERSON, Gordon A. ,  BAKER, Erin M.

IPC: H01J49/06

CPC classification number: H01J49/062

Abstract: An ion manipulation method and device to prevent loss of ions is disclosed. The device includes a pair of surfaces. An inner array of electrodes is coupled to the surfaces. A RF voltage and a DC voltage are alternately applied to the inner array of electrodes. The applied RF voltage is alternately positive and negative so that immediately adjacent or nearest neighbor RF applied electrodes are supplied with RF signals that are approximately 180 degrees out of phase.

Abstract translation: 公开了一种用于防止离子损失的离子操作方法和装置。 该装置包括一对表面。 电极的内部阵列耦合到表面。 RF电压和DC电压交替施加到电极的内部阵列。 施加的RF电压交替地是正的和负的，使得紧邻或最近邻RF施加的电极被提供有大约相差180度的RF信号。

公开(公告)号：WO2014109812A1

公开(公告)日：2014-07-17

申请号：PCT/US2013/066773

申请日：2013-10-25

Applicant: BATTELLE MEMORIAL INSTITUTE

Inventor： SHI, Tujin ,  QIAN, Weijun ,  FILLMORE, Thomas L. ,  SUN, Xuefei ,  SMITH, Richard D.

IPC: C40B30/04

CPC classification number: G01N33/6848 ,  G01N30/72 ,  G01N30/8631 ,  G01N33/50 ,  G01N33/6842 ,  G01N2030/8831 ,  G01N2458/15 ,  G01N2560/00

Abstract: Antibody-free processes are disclosed that provide accurate quantification of a wide variety of low-abundance target analytes in complex samples. The processes can employ high-pressure, high resolution chromatographic separations for analyte enrichment. Intelligent selection of target fractions may be performed via on line Selected Reaction Monitoring (SRM) or off-line rapid screening of internal standards. Quantification may be performed on individual or multiplexed fractions. Applications include analyses of, e.g., very low abundance proteins or candidate biomarkers in plasma, cell, or tissue samples without the need for affinity specific reagents.

Abstract translation: 公开了无抗体方法，其提供复杂样品中各种低丰度目标分析物的准确定量。 该过程可以采用高压，高分辨率色谱分离来进行分析物富集。 目标分数的智能选择可以通过在线选择反应监测（SRM）或离线快速筛选内部标准进行。 可以对单个或多个分数进行定量。 应用包括例如血浆，细胞或组织样品中非常低丰度蛋白或候选生物标志物的分析，而不需要亲和力特异性试剂。