Method and apparatus for obtaining a suspension of particles

    公开(公告)号:AU7999800A

    公开(公告)日:2001-05-10

    申请号:AU7999800

    申请日:2000-10-05

    Abstract: The present invention is a method and apparatus for obtaining a suspension of fine particles. The method has the steps of incorporating a compound in a variable density fluid as a fluid premixture, discharging the fluid premixture through a nozzle into a receiving liquid and forming particles of the compound. For certain compounds, mixing a surfactant with the receiving liquid prevents and retards agglomeration of the particles, and heating the nozzle prevents the formation of ice. The compound is preferably a pharmaceutical, and a biocompatible supercritical solvent maximizes solubility of the compound in the premixture. Fine particles of the compound are produced by rapid expansion of the supercritical fluid premixture in the receiving liquid.

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