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公开(公告)号：AU657331B2
公开(公告)日：1995-03-09
申请号：AU1892792
申请日：1992-04-29
Applicant: BAXTER DIAGNOSTICS INC
Inventor： JOHNSTON JUDITH , FELLAND TRACY , BASCOMB SHOSHANA , GODSEY JAMES H
Abstract: In an assay for determination of beta-lactam antibiotic resistance in a target bacterial strain, the strain is grown in the presence of both a beta-lactamese inducing antibiotic and a beta-lactam indicator antibiotic [which kills or inhibits the growth of bacteria] unable to hydrolyze beta-lactam antibiotics. Growth, indicative of drug resistance in the target strain, is monitored by detecting a fluorophor released by the enzymatic cleavage of a metabolizable fluorogenic compound.
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