公开(公告)号：ES2076556T3

公开(公告)日：1995-11-01

申请号：ES91920381

申请日：1991-10-30

Applicant: BAXTER DIAGNOSTICS INC

Inventor： MORRIS ROGER JAMES ,  BASCOMB SHOSHANA ,  OLSON CAROLYN SHELCHUK

IPC: C12Q1/26 ,  G01N21/17 ,  G01N21/53 ,  G01N21/78

Abstract: A process to determine the concentration of any substance in a colorimetric, turbidimetric or nephelometric reaction using a fluorometric detector to measure fluorescence intensity. In particular, a change in color can be monitored by observing the measurement of fluorescence intensity of a fluorophore in an inert matrix. The absorption spectrum of the chromophore may overlap the excitation and/or emission spectrum of the fluorophore, thereby allowing the change in fluorescence to be related to the intensity of color in the reaction and thus related to the quantity of the substance of interest.

公开(公告)号：MX9101919A

公开(公告)日：1992-07-08

申请号：MX9101919

申请日：1991-11-05

Applicant: BAXTER DIAGNOSTICS INC

Inventor： MORRIS ROGER J ,  BASCOMB SHOSHANA ,  OLSON CAROLYN SHELSHUK

IPC: C12Q1/26 ,  G01N21/17 ,  G01N21/53 ,  G01N21/78 ,  G01J3/46

Abstract: A process to determine the concentration of any substance in a colorimetric, turbidimetric or nephelometric reaction using a fluorometric detector to measure fluorescence intensity. In particular, a change in color can be monitored by observing the measurement of fluorescence intensity of a fluorophore in an inert matrix. The absorption spectrum of the chromophore may overlap the excitation and/or emission spectrum of the fluorophore, thereby allowing the change in fluorescence to be related to the intensity of color in the reaction and thus related to the quantity of the substance of interest.

公开(公告)号：CA2070806A1

公开(公告)日：1992-05-06

申请号：CA2070806

申请日：1991-10-30

Applicant: BAXTER DIAGNOSTICS INC

Inventor： MORRIS ROGER J ,  BASCOMB SHOSHANA ,  OLSON CAROLYN S

IPC: C12Q1/26 ,  G01N21/17 ,  G01N21/53 ,  G01N21/78 ,  G01N21/84

Abstract: 2070806 9208123 PCTABS00013 The present invention relates to a process to determine the concentration of any substance in a colorimetric, turbidimetric or nephelometric reaction using a fluorometric detector to measure fluorescence intensity. In particular, a change in color can be monitored by observing the measurement of fluorescence intensity of a fluorophore in an inert matrix. The absorption spectrum of the chromophore may overlap the excitation and/or emission spectrum of the fluorophore, thereby allowing the change in fluoroscence to be related to the intensity of color in the reaction and thus related to the quantity of the substance of interest.

公开(公告)号：DE69110658T2

公开(公告)日：1996-03-21

申请号：DE69110658

申请日：1991-10-30

Applicant: BAXTER DIAGNOSTICS INC

Inventor： MORRIS ROGER ,  BASCOMB SHOSHANA ,  OLSON CAROLYN

IPC: C12Q1/26 ,  G01N21/17 ,  G01N21/53 ,  G01N21/78

Abstract: A process to determine the concentration of any substance in a colorimetric, turbidimetric or nephelometric reaction using a fluorometric detector to measure fluorescence intensity. In particular, a change in color can be monitored by observing the measurement of fluorescence intensity of a fluorophore in an inert matrix. The absorption spectrum of the chromophore may overlap the excitation and/or emission spectrum of the fluorophore, thereby allowing the change in fluorescence to be related to the intensity of color in the reaction and thus related to the quantity of the substance of interest.

公开(公告)号：AU652603B2

公开(公告)日：1994-09-01

申请号：AU9161091

申请日：1991-12-23

Applicant: BAXTER DIAGNOSTICS INC

Inventor： BADAL ROBERT ,  KELLEY ROGER ,  SAND THEODORE T ,  BASCOMB SHOSHANA

IPC: C12Q1/04 ,  C12Q1/18

公开(公告)号：AU652592B2

公开(公告)日：1994-09-01

申请号：AU8937191

申请日：1991-10-30

Applicant: BAXTER DIAGNOSTICS INC

Inventor： MORRIS ROGER JAMES ,  BASCOMB SHOSHANA ,  OLSON CAROLYN SHELCHUK

IPC: C12Q1/26 ,  G01N21/17 ,  G01N21/53 ,  G01N21/78 ,  G01N21/64

Abstract: A process to determine the concentration of any substance in a colorimetric, turbidimetric or nephelometric reaction using a fluorometric detector to measure fluorescence intensity. In particular, a change in color can be monitored by observing the measurement of fluorescence intensity of a fluorophore in an inert matrix. The absorption spectrum of the chromophore may overlap the excitation and/or emission spectrum of the fluorophore, thereby allowing the change in fluorescence to be related to the intensity of color in the reaction and thus related to the quantity of the substance of interest.

公开(公告)号：NO923436A

公开(公告)日：1992-09-03

申请号：NO923436

申请日：1992-09-03

Applicant: BAXTER DIAGNOSTICS INC

Inventor： MORRIS ROGER JAMES ,  BASCOMB SHOSHANA ,  BOBOLIS JAMIE ,  SHERMAN DAVID ,  OLSON CAROLYN SHELCHUK

IPC: C12M1/34 ,  C12Q1/06 ,  G01N20060101 ,  G01N21/27 ,  G01N21/64 ,  G01N21/78 ,  G01N21/80 ,  G01N33/49 ,  G01N

CPC classification number: G01N21/80 ,  C12Q1/06 ,  G01N21/272

公开(公告)号：AU657331B2

公开(公告)日：1995-03-09

申请号：AU1892792

申请日：1992-04-29

Applicant: BAXTER DIAGNOSTICS INC

Inventor： JOHNSTON JUDITH ,  FELLAND TRACY ,  BASCOMB SHOSHANA ,  GODSEY JAMES H

IPC: C12Q1/18 ,  C12Q1/02 ,  C12Q1/04

Abstract: In an assay for determination of beta-lactam antibiotic resistance in a target bacterial strain, the strain is grown in the presence of both a beta-lactamese inducing antibiotic and a beta-lactam indicator antibiotic [which kills or inhibits the growth of bacteria] unable to hydrolyze beta-lactam antibiotics. Growth, indicative of drug resistance in the target strain, is monitored by detecting a fluorophor released by the enzymatic cleavage of a metabolizable fluorogenic compound.

公开(公告)号：NO923436D0

公开(公告)日：1992-09-03

申请号：NO923436

申请日：1992-09-03

Applicant: BAXTER DIAGNOSTICS INC

Inventor： MORRIS ROGER JAMES ,  BASCOMB SHOSHANA ,  BOBOLIS JAMIE ,  SHERMAN DAVID

IPC: C12M1/34 ,  C12Q1/06 ,  G01N20060101 ,  G01N21/27 ,  G01N21/64 ,  G01N21/78 ,  G01N21/80 ,  G01N33/49 ,  G01N

公开(公告)号：CA2077560A1

公开(公告)日：1992-07-05

申请号：CA2077560

申请日：1991-12-23

Applicant: BAXTER DIAGNOSTICS INC

Inventor： MORRIS ROGER J ,  BASCOMB SHOSHANA ,  BOBOLIS JAMIE ,  SHERMAN DAVID ,  OLSON CAROLYN

IPC: C12M1/34 ,  C12Q1/06 ,  G01N20060101 ,  G01N21/27 ,  G01N21/64 ,  G01N21/78 ,  G01N21/80 ,  G01N33/49 ,  G01N33/52

Abstract: 2077560 9212413 PCTABS00014 The present invention is a multi-layer blood culture sensor which includes a pH sensitive absorbance dye encapsulated in or isolated by a first light transmissive gas permeable, proton impermeable matrix (2) and a pH insensitive fluorescence dye in a second matrix (4), the first and second matrices being spectrally coupled, and a method to use this sensor to detect microorganisms in a blood culture bottle.