公开(公告)号：EP0357724A4

公开(公告)日：1990-02-20

申请号：EP89902474

申请日：1989-02-10

Applicant: BAXTER INT

Inventor： BAES MICHEL

IPC: A61K31/19 ,  A61K9/08 ,  A61K31/715 ,  A61K47/12 ,  A61P7/02

CPC classification number: A61K31/715 ,  A61K47/12 ,  A61K31/19

Abstract: A heat-sterilizable, stable aqueous solution typically includes in the solution from 5 to 1000 USP units of heparin per ml. and from 10 to 100 millimoles of calcium lactate per liter of said solution. This solution stabilizes the heparin present and permits its pasteurization or sterilization without significant loss of heparin activity. The solution may be used with collected blood or preferably blood plasma for improvements in the extraction of factor VIII activity therefrom.

Abstract translation: 可热灭菌的稳定水溶液通常在溶液中包含每毫升5至1000USP单位的肝素。 和每升所述溶液10至100毫摩尔的乳酸钙。 该溶液稳定肝素存在并允许其巴氏消毒或灭菌而不显着损失肝素活性。 该溶液可以与收集的血液或优选血浆一起使用，以改善由此提取因子VIII活性。

公开(公告)号：CA2062807A1

公开(公告)日：1991-11-08

申请号：CA2062807

申请日：1991-04-01

Applicant: BAXTER INT

Inventor： DEBRAUWERE JACK ,  MATHIAS JEAN-MARIE ,  PAYRAT JEAN-MARC ,  BAES MICHEL

IPC: A61K31/19 ,  A61K31/715 ,  A61K35/14 ,  A61K35/16 ,  C07K14/755 ,  A61K31/725

Abstract: 2062807 9116913 PCTABS00008 A heat-sterilizable, stable aqueous solution typically includes in the solution from 5 to 1000 USP units of heparin per ml. and from 10 to 250 millimoles of calcium lactate per liter of said solution. This solution stabilizes the heparin present and permits its pasteurization or sterilization without significant loss of heparin activity. The solution may be used with collected blood or preferably blood plasma for improvements in the extraction of factor VIII activity therefrom.

公开(公告)号：DE68903709D1

公开(公告)日：1993-01-14

申请号：DE68903709

申请日：1989-02-10

Applicant: BAXTER INT

Inventor： BAES MICHEL

IPC: A61K31/19 ,  A61K31/725