公开(公告)号：WO2005072706A3

公开(公告)日：2005-11-24

申请号：PCT/US2005001861

申请日：2005-01-21

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA ,  WERLING JANE ,  CHAUBAL MAHESH V ,  KIPP JAMES E ,  RABINOW BARRETT E

Inventor： WERLING JANE ,  CHAUBAL MAHESH V ,  KIPP JAMES E ,  RABINOW BARRETT E

IPC: A61K9/10 ,  A61K9/14 ,  A61K9/51 ,  A61K31/00 ,  A61K31/551 ,  A61K31/7072 ,  A61K31/7076

CPC classification number: A61K9/10 ,  A61K9/5123 ,  A61K31/00 ,  A61K31/551 ,  A61K31/7072 ,  A61K31/7076

Abstract: The present invention provides compositions comprising dispersions of anti-retroviral agents and methods of manufacture. The nanosuspensions are made by the process of microprecipitation and energy addition. Preferably, the nanosuspensions are made by the tandem process of microprecipitation-homogenization.

Abstract translation: 本发明提供了包含抗逆转录病毒剂分散体和制造方法的组合物。 纳米悬浮液是通过微量沉淀和能量添加过程制成的。 优选地，纳米悬浮液通过微量沉淀 - 均质化的串联过程制成。

公开(公告)号：CA2761801C

公开(公告)日：2018-01-02

申请号：CA2761801

申请日：2010-05-13

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： RABINOW BARRETT ,  BAIRSTOW SHAWN F ,  CHAUBAL MAHESH V ,  LEE SARAH ,  WERLING JANE

IPC: A61K9/14 ,  A61K31/337 ,  A61P35/00

Abstract: The present disclosure is directed to surface-modified particles and to methods of making and using the same. The surface-modified particles comprise a particle core and a coating associated with the particle core, wherein the particle core comprises an active agent, the coating comprises a surfactant having formula (I) or a salt thereof, and the surface-modified particle has an average size from about 1 nm to about 2,000 nm:

公开(公告)号：CA2554246A1

公开(公告)日：2005-08-11

申请号：CA2554246

申请日：2005-01-21

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： KIPP JAMES E ,  RABINOW BARRETT E ,  CHAUBAL MAHESH V ,  WERLING JANE

IPC: A61K9/10 ,  A61K9/14 ,  A61K9/51 ,  A61K31/00 ,  A61K31/551 ,  A61K31/7072 ,  A61K31/7076

Abstract: The present invention provides compositions comprising dispersions of anti- retroviral agents and methods of manufacture. The nanosuspensions are made b y the process of microprecipitation and energy addition. Preferably, the nanosuspensions are made by the tandem process of microprecipitation- homogenization.

公开(公告)号：MX2011012196A

公开(公告)日：2013-05-30

申请号：MX2011012196

申请日：2010-05-13

Applicant: BAXTER INT

Inventor： WERLING JANE ,  BAIRSTOW SHAWN F ,  RABINOW BARRETT ,  CHAUBAL MAHESH V ,  LEE SARAH

IPC: A61K31/337 ,  A61K9/14 ,  A61K47/34 ,  A61P35/00

Abstract: La presente invención está dirigida a partículas de superficie modificada y a métodos para hacer y utilizar las mismas. Las partículas de superficie modificada comprenden un núcleo de partícula y un revestimiento asociado con el núcleo de partícula, en donde el núcleo de partícula comprende un agente activo, el revestimiento comprende un agente tensoactivo que tienen la fórmula (I) o una sal del mismo, y la partícula de superficie modificada tiene un tamaño promedio de aproximadamente 1 nm a aproximadamente 2,000 nm.

公开(公告)号：SG176055A1

公开(公告)日：2011-12-29

申请号：SG2011083789

申请日：2010-05-13

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： RABINOW BARRETT ,  BAIRSTOW SHAWN F ,  CHAUBAL MAHESH V ,  LEE SARAH ,  WERLING JANE

Abstract: The present disclosure is directed to surface-modified particles and to methods of making and using the same. The surface-modified particles comprise a particle core and a coating associated with the particle core, wherein the particle core comprises an active agent, the coating comprises a surfactant having formula (I) or a salt thereof, and the surface-modified particle has an average size from about 1 nm to about 2,000 nm:

公开(公告)号：AU2010249008A1

公开(公告)日：2011-12-01

申请号：AU2010249008

申请日：2010-05-13

Applicant: BAXTER HEALTHCARE SA ,  BAXTER INT

Inventor： BARRETT RABINOW ,  BAIRSTOW SHAWN F ,  CHAUBAL MAHESH V ,  SARAH LEE ,  JANE WERLING

IPC: A61K9/14 ,  A61K31/337 ,  A61K47/34 ,  A61P35/00

Abstract: The present disclosure is directed to surface-modified particles and to methods of making and using the same. The surface-modified particles comprise a particle core and a coating associated with the particle core, wherein the particle core comprises an active agent, the coating comprises a surfactant having formula (I) or a salt thereof, and the surface-modified particle has an average size from about 1 nm to about 2,000 nm:

公开(公告)号：HK1170679A1

公开(公告)日：2013-03-08

申请号：HK12111567

申请日：2012-11-14

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： RABINOW BARRETT ,  BAIRSTOW SHAWN F ,  CHAUBAL MAHESH V ,  LEE SARAH ,  WERLING JANE

IPC: A61P20060101 ,  A61K20060101

Abstract: The present disclosure is directed to surface-modified particles and to methods of making and using the same. The surface-modified particles comprise a particle core and a coating associated with the particle core, wherein the particle core comprises an active agent, the coating comprises a surfactant having formula I, and the surface-modified particle has an average size from about 1 nm to about 2,000 nm:

公开(公告)号：ZA200606051B

公开(公告)日：2008-04-30

申请号：ZA200606051

申请日：2006-07-21

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： JANE WERLING ,  CHAUBAL MAHESH V ,  KIPP JAMES E ,  RABINOW BARRETT E

IPC: A61K20090101 ,  A61K9/10 ,  A61K9/14 ,  A61K9/51 ,  A61K31/00 ,  A61K31/551 ,  A61K31/7072 ,  A61K31/7076

Abstract: The present invention provides compositions comprising dispersions of anti-retroviral agents and methods of manufacture. The nanosuspensions are made by the process of microprecipitation and energy addition. Preferably, the nanosuspensions are made by the tandem process of microprecipitation-homogenization.

公开(公告)号：BRPI0507308A

公开(公告)日：2007-06-26

申请号：BRPI0507308

申请日：2005-01-21

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： WERLING JANE ,  CHAUBAL MAHESH V ,  KIPP JAMES E ,  RABINOW BARRETT E

IPC: A61K9/10 ,  A61K9/14 ,  A61K9/51 ,  A61K31/00 ,  A61K31/551 ,  A61K31/7072 ,  A61K31/7076

Abstract: The present invention provides compositions comprising dispersions of anti-retroviral agents and methods of manufacture. The nanosuspensions are made by the process of microprecipitation and energy addition. Preferably, the nanosuspensions are made by the tandem process of microprecipitation-homogenization.

公开(公告)号：BRPI1010903A2

公开(公告)日：2016-03-15

申请号：BRPI1010903

申请日：2010-05-13

Applicant: BAXTER HEALTHCARE SA ,  BAXTER INT

Inventor： RABINOW BARRETT ,  WERLING JANE ,  CHAUBAL MAHESH V ,  LEE SARAH ,  BAIRSTOW SHAWN F

IPC: A61K9/14 ,  A61K31/337 ,  A61K47/34 ,  A61P35/00