公开(公告)号：CA2761801C

公开(公告)日：2018-01-02

申请号：CA2761801

申请日：2010-05-13

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： RABINOW BARRETT ,  BAIRSTOW SHAWN F ,  CHAUBAL MAHESH V ,  LEE SARAH ,  WERLING JANE

IPC: A61K9/14 ,  A61K31/337 ,  A61P35/00

Abstract: The present disclosure is directed to surface-modified particles and to methods of making and using the same. The surface-modified particles comprise a particle core and a coating associated with the particle core, wherein the particle core comprises an active agent, the coating comprises a surfactant having formula (I) or a salt thereof, and the surface-modified particle has an average size from about 1 nm to about 2,000 nm:

公开(公告)号：SG176055A1

公开(公告)日：2011-12-29

申请号：SG2011083789

申请日：2010-05-13

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： RABINOW BARRETT ,  BAIRSTOW SHAWN F ,  CHAUBAL MAHESH V ,  LEE SARAH ,  WERLING JANE

Abstract: The present disclosure is directed to surface-modified particles and to methods of making and using the same. The surface-modified particles comprise a particle core and a coating associated with the particle core, wherein the particle core comprises an active agent, the coating comprises a surfactant having formula (I) or a salt thereof, and the surface-modified particle has an average size from about 1 nm to about 2,000 nm:

公开(公告)号：HK1170679A1

公开(公告)日：2013-03-08

申请号：HK12111567

申请日：2012-11-14

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： RABINOW BARRETT ,  BAIRSTOW SHAWN F ,  CHAUBAL MAHESH V ,  LEE SARAH ,  WERLING JANE

IPC: A61P20060101 ,  A61K20060101

Abstract: The present disclosure is directed to surface-modified particles and to methods of making and using the same. The surface-modified particles comprise a particle core and a coating associated with the particle core, wherein the particle core comprises an active agent, the coating comprises a surfactant having formula I, and the surface-modified particle has an average size from about 1 nm to about 2,000 nm:

公开(公告)号：MX2011012196A

公开(公告)日：2013-05-30

申请号：MX2011012196

申请日：2010-05-13

Applicant: BAXTER INT

Inventor： WERLING JANE ,  BAIRSTOW SHAWN F ,  RABINOW BARRETT ,  CHAUBAL MAHESH V ,  LEE SARAH

IPC: A61K31/337 ,  A61K9/14 ,  A61K47/34 ,  A61P35/00

Abstract: La presente invención está dirigida a partículas de superficie modificada y a métodos para hacer y utilizar las mismas. Las partículas de superficie modificada comprenden un núcleo de partícula y un revestimiento asociado con el núcleo de partícula, en donde el núcleo de partícula comprende un agente activo, el revestimiento comprende un agente tensoactivo que tienen la fórmula (I) o una sal del mismo, y la partícula de superficie modificada tiene un tamaño promedio de aproximadamente 1 nm a aproximadamente 2,000 nm.

公开(公告)号：BRPI1010903A2

公开(公告)日：2016-03-15

申请号：BRPI1010903

申请日：2010-05-13

Applicant: BAXTER HEALTHCARE SA ,  BAXTER INT

Inventor： RABINOW BARRETT ,  WERLING JANE ,  CHAUBAL MAHESH V ,  LEE SARAH ,  BAIRSTOW SHAWN F

IPC: A61K9/14 ,  A61K31/337 ,  A61K47/34 ,  A61P35/00

公开(公告)号：ES2509919T3

公开(公告)日：2014-10-20

申请号：ES10719211

申请日：2010-05-13

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： RABINOW BARRETT ,  BAIRSTOW SHAWN F ,  CHAUBAL MAHESH V ,  LEE SARAH ,  WERLING JANE

IPC: A61K9/14 ,  A61K31/337 ,  A61K31/365 ,  A61K31/415 ,  A61K31/427 ,  A61K31/444 ,  A61K31/496 ,  A61K31/513 ,  A61K31/538 ,  A61K31/551 ,  A61K31/708 ,  A61K47/34 ,  A61P35/00

Abstract: Partícula de superficie modificada que comprende un núcleo de partícula y un revestimiento asociado al núcleo de partícula, comprendiendo el núcleo de partícula un principio activo seleccionado de entre el grupo consistente en moléculas pequeñas, péptidos y proteínas, comprendiendo el revestimiento un agente tensioactivo de fórmula I o una sal del mismo, y presentando la partícula de superficie modificada un tamaño medio entre aproximadamente 1 nm y aproximadamente 2.000 nm: donde n y m son 1; R1, R2 y R3 son metilo; y R4 y R5 se seleccionan independientemente entre el grupo consistente en cis-9-octadecenoílo y cis-9- octadecenilo.

公开(公告)号：AU2010249008B2

公开(公告)日：2014-06-05

申请号：AU2010249008

申请日：2010-05-13

Applicant: BAXTER HEALTHCARE SA ,  BAXTER INT

Inventor： RABINOW BARRETT ,  BAIRSTOW SHAWN F ,  CHAUBAL MAHESH V ,  LEE SARAH ,  WERLING JANE

IPC: A61K9/14 ,  A61K31/337 ,  A61K47/34 ,  A61P35/00

Abstract: The present disclosure is directed to surface-modified particles and to methods of making and using the same. The surface-modified particles comprise a particle core and a coating associated with the particle core, wherein the particle core comprises an active agent, the coating comprises a surfactant having formula (I) or a salt thereof, and the surface-modified particle has an average size from about 1 nm to about 2,000 nm:

公开(公告)号：CA2761801A1

公开(公告)日：2010-11-18

申请号：CA2761801

申请日：2010-05-13

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： RABINOW BARRETT ,  BAIRSTOW SHAWN F ,  CHAUBAL MAHESH V ,  LEE SARAH ,  WERLING JANE

IPC: A61K9/14 ,  A61K31/337 ,  A61K47/34 ,  A61P35/00

Abstract: The present disclosure is directed to surface-modified particles and to methods of making and using the same. The surface-modified particles comprise a particle core and a coating associated with the particle core, wherein the particle core comprises an active agent, the coating comprises a surfactant having formula (I) or a salt thereof, and the surface-modified particle has an average size from about 1 nm to about 2,000 nm: