公开(公告)号：CA1261701A

公开(公告)日：1989-09-26

申请号：CA496681

申请日：1985-12-02

Applicant: BAXTER INT

Inventor： NEEDHAM THOMAS E ,  WRIGHT JEREMY C ,  PEARSON STEVE ,  CHILAMKURTI RAO ,  KOPP CLINTON V

IPC: A61M5/168 ,  A61M5/14 ,  A61M39/00

Abstract: DRUG DELIVERY APPARATUS PREVENTING LOCAL AND SYSTEMIC TOXICITY An apparatus is provided for the safe, passive reconstitution of a drug or other beneficial agent, without requiring manual reconstitution steps. The apparatus includes a housing, preferably having a receptacle "in-line" in an administration set and forming part of an intravenous delivery system, and a cartridge adapted for receiving a beneficial agent or beneficial agent and carrier. The cartridge is plugged into the receptacle to initiate reconstitution of the agent. The apparatus creates first and second delivery modes, in which the delivery rate of the agent to a patient is independent from and dependent upon, respectively, the fluid flow rate through the intravenous delivery system.

公开(公告)号：AU5233186A

公开(公告)日：1986-07-01

申请号：AU5233186

申请日：1985-11-29

Applicant: BAXTER INT

Inventor： NEEDHAM THOMAS E ,  WRIGHT JEREMY C ,  STEVE PEARSON ,  CHILAMKURTI RAO N ,  KOPP CLINTON V

IPC: A61M5/168 ,  A61M5/14 ,  A61M39/00

Abstract: Apparatus for safe delivery of a beneficial agent to a patient comprising a chamber (98) for the agent through which a fluid passes to the patient and means for controlling the rate of delivery in two alternative modes. In the first mode fluid flow through the chamber is high enough to provide delivery of the agent at a rate independent of the actual fluid flow rate to provide a therapeutic dose of the agent in approximately thirty minutes. In the second mode, the fluid flow rate in the chamber is low enough for rate delivery of the agent to be at least partially dependent on fluid flow rate through the chamber. The control means ensures that a toxic concentration is not delivered to the patient nor develops in the patient's bloodstream. The control means may take various forms.

公开(公告)号：AU592546B2

公开(公告)日：1990-01-18

申请号：AU5233186

申请日：1985-11-29

Applicant: BAXTER INT

Inventor： NEEDHAM THOMAS E ,  WRIGHT JEREMY C ,  PEARSON STEVE ,  CHILAMKURTI RAO N ,  KOPP CLINTON V

IPC: A61M5/168 ,  A61M5/14 ,  A61M39/00

Abstract: Apparatus for safe delivery of a beneficial agent to a patient comprising a chamber (98) for the agent through which a fluid passes to the patient and means for controlling the rate of delivery in two alternative modes. In the first mode fluid flow through the chamber is high enough to provide delivery of the agent at a rate independent of the actual fluid flow rate to provide a therapeutic dose of the agent in approximately thirty minutes. In the second mode, the fluid flow rate in the chamber is low enough for rate delivery of the agent to be at least partially dependent on fluid flow rate through the chamber. The control means ensures that a toxic concentration is not delivered to the patient nor develops in the patient's bloodstream. The control means may take various forms.