公开(公告)号：NO172277C

公开(公告)日：1993-06-30

申请号：NO863114

申请日：1986-08-01

Applicant: BAXTER INT

Inventor： ZDEB BRIAN ,  PEARSON STEVE ,  SLATER GLENN L

IPC: A61J3/00 ,  A61M5/14 ,  A61M39/00

公开(公告)号：CA1261220A

公开(公告)日：1989-09-26

申请号：CA496680

申请日：1985-12-02

Applicant: BAXTER INT

Inventor： ZDEB BRIAN ,  PEARSON STEVE ,  SLATER GLENN L

IPC: A61J3/00 ,  A61M5/14 ,  A61M39/00

Abstract: HOUSING ENABLING PASSIVE MIXING OF A BENEFICIAL AGENT WITH A DILUENT A housing is provided for insertion in an intravenous delivery system including a fluid source and a fluid conduit. The housing is adapted for receiving a beneficial agent to be mixed with fluid flowing through the fluid conduit. The beneficial agent is reconstituted within the housing, eliminating the need for manual reconstitution. The housing may comprise a separate receptacle and cartridge in which the receptacle is manufactured "in-line" in an administration set and the cartridge is adapted for receiving a beneficial agent. In one embodiment of the invention, the cartridge is a standard drug vial.

公开(公告)号：DE3585530D1

公开(公告)日：1992-04-09

申请号：DE3585530

申请日：1985-11-29

Applicant: BAXTER INT

Inventor： NEEDHAM E ,  WRIGHT C ,  PEARSON STEVE ,  CHILAMKURTI N ,  KOPP V

IPC: A61M5/168 ,  A61M5/14 ,  A61M39/00

Abstract: Apparatus for safe delivery of a beneficial agent to a patient comprising a chamber (98) for the agent through which a fluid passes to the patient and means for controlling the rate of delivery in two alternative modes. In the first mode fluid flow through the chamber is high enough to provide delivery of the agent at a rate independent of the actual fluid flow rate to provide a therapeutic dose of the agent in approximately thirty minutes. In the second mode, the fluid flow rate in the chamber is low enough for rate delivery of the agent to be at least partially dependent on fluid flow rate through the chamber. The control means ensures that a toxic concentration is not delivered to the patient nor develops in the patient's bloodstream. The control means may take various forms.

公开(公告)号：CA1284072C

公开(公告)日：1991-05-14

申请号：CA606370

申请日：1989-07-21

Applicant: BAXTER INT

Inventor： ZDEB BRIAN ,  PEARSON STEVE ,  SLATER GLENN L

IPC: A61J3/00 ,  A61M5/14 ,  A61M39/00

Abstract: HOUSING ENABLING PASSIVE MIXING OF A BENEFICIAL AGENT WITH A DILUENT A housing is provided for insertion in an intravenous delivery system including a fluid source and a fluid conduit. The housing is adapted for receiving a beneficial agent to be mixed with fluid flowing through the fluid conduit. The beneficial agent is reconstituted within the housing, eliminating the need for manual reconstitution. The housing may comprise a separate receptacle and cartridge in which the receptacle is manufactured "in-line" in an administration set and the cartridge is adapted for receiving a beneficial agent. In one embodiment of the invention, the cartridge is a standard drug vial.

公开(公告)号：AU592546B2

公开(公告)日：1990-01-18

申请号：AU5233186

申请日：1985-11-29

Applicant: BAXTER INT

Inventor： NEEDHAM THOMAS E ,  WRIGHT JEREMY C ,  PEARSON STEVE ,  CHILAMKURTI RAO N ,  KOPP CLINTON V

IPC: A61M5/168 ,  A61M5/14 ,  A61M39/00

Abstract: Apparatus for safe delivery of a beneficial agent to a patient comprising a chamber (98) for the agent through which a fluid passes to the patient and means for controlling the rate of delivery in two alternative modes. In the first mode fluid flow through the chamber is high enough to provide delivery of the agent at a rate independent of the actual fluid flow rate to provide a therapeutic dose of the agent in approximately thirty minutes. In the second mode, the fluid flow rate in the chamber is low enough for rate delivery of the agent to be at least partially dependent on fluid flow rate through the chamber. The control means ensures that a toxic concentration is not delivered to the patient nor develops in the patient's bloodstream. The control means may take various forms.

公开(公告)号：AU591883B2

公开(公告)日：1989-12-21

申请号：AU5203686

申请日：1985-11-29

Applicant: BAXTER INT

Inventor： ZDEB BRIAN ,  PEARSON STEVE ,  SLATER GLENN L

IPC: A61J3/00 ,  A61M5/14 ,  A61M39/00

公开(公告)号：NO172277B

公开(公告)日：1993-03-22

申请号：NO863114

申请日：1986-08-01

Applicant: BAXTER INT

Inventor： ZDEB BRIAN ,  PEARSON STEVE ,  SLATER GLENN L

IPC: A61J3/00 ,  A61M5/14 ,  A61M39/00

公开(公告)号：DE3585528D1

公开(公告)日：1992-04-09

申请号：DE3585528

申请日：1985-11-29

Applicant: BAXTER INT

Inventor： ZDEB BRIAN ,  PEARSON STEVE ,  SLATER L

IPC: A61J3/00 ,  A61M5/14 ,  A61M39/00

公开(公告)号：CA1261701A

公开(公告)日：1989-09-26

申请号：CA496681

申请日：1985-12-02

Applicant: BAXTER INT

Inventor： NEEDHAM THOMAS E ,  WRIGHT JEREMY C ,  PEARSON STEVE ,  CHILAMKURTI RAO ,  KOPP CLINTON V

IPC: A61M5/168 ,  A61M5/14 ,  A61M39/00

Abstract: DRUG DELIVERY APPARATUS PREVENTING LOCAL AND SYSTEMIC TOXICITY An apparatus is provided for the safe, passive reconstitution of a drug or other beneficial agent, without requiring manual reconstitution steps. The apparatus includes a housing, preferably having a receptacle "in-line" in an administration set and forming part of an intravenous delivery system, and a cartridge adapted for receiving a beneficial agent or beneficial agent and carrier. The cartridge is plugged into the receptacle to initiate reconstitution of the agent. The apparatus creates first and second delivery modes, in which the delivery rate of the agent to a patient is independent from and dependent upon, respectively, the fluid flow rate through the intravenous delivery system.