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1.发明公开
公开(公告)号：EP1017405A4
公开(公告)日：2003-01-22
申请号：EP98931462
申请日：1998-06-22
Applicant: BAXTER INT
Inventor： HAI TON THAT , PEREIRA DAVID E , NELSON DEANNA J
IPC: A61K38/16 , A61K38/00 , A61P7/00 , A61P43/00 , C07G3/00 , C07K14/805 , C08B37/00 , C08G63/48 , A61K38/42 , A61K47/48 , C07H5/06
CPC classification number: C07K14/805 , A61K38/00
Abstract: Novel polysaccharide compounds are disclosed for decorating biomolecular surfaces to increase isotropic size and mask antigenicity. The oligosaccharides may by synthesized as repeating disaccharide units, or may be derived by acid hydrolysis of naturally occurring polysaccharides. Such natural sources include chondroitins obtained from shark cartilage, or hyaluronic acid. The polyanionic sulfate groups contained in the sugar moieties impart negative charges which repel the molecules from the negatively charged wall of capillaries, to lengthen retention times of decorated drug molecules, such as cross-linked hemoglobin, in the peripheral circulation.
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公开(公告)号：AU742849B2
公开(公告)日：2002-01-17
申请号：AU8158698
申请日：1998-06-22
Applicant: BAXTER INT
Inventor： HAI TON THAT , PEREIRA DAVID E , NELSON DEANNA J
IPC: A61K38/16 , A61K38/00 , A61P7/00 , A61P43/00 , C07G3/00 , C07K14/805 , C08B37/00 , C08G63/48 , A61K35/14 , A61K39/385 , C07H1/00
Abstract: Novel polysaccharide compounds are disclosed for decorating biomolecular surfaces to increase isotropic size and mask antigenicity. The oligosaccharides may be synthesized as repeating disaccharide units, or may be derived by acid hydrolysis of naturally occurring polysaccharides. Such natural sources include chondroitins obtained from shark cartilage, or hyaluronic acid. The polyanionic sulfate groups contained in the sugar moieties impart negative charges which repel the molecules from the negatively charged wall of capillaries, to lengthen retention times of decorated drug molecules, such as crosslinked hemoglobin, in the peripheral circulation.
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公开(公告)号：AU9403098A
公开(公告)日：1999-05-03
申请号：AU9403098
申请日：1998-09-22
Applicant: BAXTER INT
Inventor： HAI TON THAT , NELSON DEANNA J , PEREIRA DAVID E
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公开(公告)号：CA2296700A1
公开(公告)日：1999-01-28
申请号：CA2296700
申请日：1998-06-22
Applicant: BAXTER INT
Inventor： HAI TON THAT , PEREIRA DAVID E , NELSON DEANNA J
IPC: A61K38/16 , A61K38/00 , A61P7/00 , A61P43/00 , C07G3/00 , C07K14/805 , C08B37/00 , C08G63/48 , A61K35/14 , C07H1/00 , A61K39/385
Abstract: Novel polysaccharide compounds are disclosed for decorating biomolecular surfaces to increase isotropic size and mask antigenicity. The oligosaccharides may by synthesized as repeating disaccharide units, or may be derived by acid hydrolysis of naturally occurring polysaccharides. Such natural sources include chondroitins obtained from shark cartilage, or hyaluronic acid. The polyanionic sulfate groups contained in the sugar moieties impart negative charges which repel the molecules from the negatively charged wall of capillaries, to lengthen retention times of decorated drug molecules, such as cross-linked hemoglobin, in the peripheral circulation.
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公开(公告)号：ZA988662B
公开(公告)日：1999-03-31
申请号：ZA988662
申请日：1998-09-22
Applicant: BAXTER INT
Inventor： HAI TON THAT , NELSON DEANNA J , PEREIRA DAVID E
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Patent Agency Ranking
公开(公告)号：AU8158698A
公开(公告)日：1999-02-10
申请号：AU8158698
申请日：1998-06-22
Applicant: BAXTER INT
Inventor： HAI TON THAT , PEREIRA DAVID E , NELSON DEANNA J
IPC: A61K38/16 , A61K38/00 , A61P7/00 , A61P43/00 , C07G3/00 , C07K14/805 , C08B37/00 , C08G63/48 , A61K35/14 , A61K39/385 , C07H1/00
Abstract: Novel polysaccharide compounds are disclosed for decorating biomolecular surfaces to increase isotropic size and mask antigenicity. The oligosaccharides may be synthesized as repeating disaccharide units, or may be derived by acid hydrolysis of naturally occurring polysaccharides. Such natural sources include chondroitins obtained from shark cartilage, or hyaluronic acid. The polyanionic sulfate groups contained in the sugar moieties impart negative charges which repel the molecules from the negatively charged wall of capillaries, to lengthen retention times of decorated drug molecules, such as crosslinked hemoglobin, in the peripheral circulation.
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公开(公告)号：AU721728B2
公开(公告)日：2000-07-13
申请号：AU3798899
申请日：1999-07-05
Applicant: BAXTER INT
Inventor： TRIMBO SUSAN , LAVERVE XAVIER , ROWE BRUCE , ROSE FRANCIS , PEREIRA DAVID E , JONES PATRICK J
IPC: A61K31/215 , A61K31/22 , A61K31/70 , C07C67/317 , C07C69/675 , C07C69/68 , C07H1/00 , C07H13/04 , C07H13/06
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公开(公告)号：AU3798899A
公开(公告)日：1999-09-02
申请号：AU3798899
申请日：1999-07-05
Applicant: BAXTER INT
Inventor： TRIMBO SUSAN , JONES PATRICK J , PEREIRA DAVID E , ROSE FRANCIS , ROWE BRUCE , LAVERVE XAVIER
IPC: A61K31/215 , A61K31/22 , A61K31/70 , C07C67/317 , C07C69/675 , C07C69/68 , C07H1/00 , C07H13/04 , C07H13/06
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公开(公告)号：AU707531B2
公开(公告)日：1999-07-15
申请号：AU5045696
申请日：1996-04-02
Applicant: BAXTER INT
Inventor： TRIMBO SUSAN , LAVERVE XAVIER , ROWE BRUCE , ROSE FRANCIS , PEREIRA DAVID E , JONAS PATRICK J
IPC: A23D9/007 , A23D9/013 , A23L1/30 , A61K31/22 , A61K31/23 , A61K31/70 , A61P3/00 , A61P3/02 , A61P3/04 , A61P3/08 , A61P43/00 , C07C69/675 , C07C69/732 , C07H13/06 , C07H13/04 , C07H1/00 , C07C69/68 , C07C67/317 , A61K31/215
Abstract: The present disclosure generally relates to the field of enteral and parenteral nutritional formulations in which enantiomerically-enriched energy substrates are used for providing high caloric density and low osmolarity. In particular monoisomeric glyceryl tri(chiral alkanoates), anomeric mixtures of alpha, beta-D-glucopyranosyl alkanoates, monoisomeric chiral alkanoic acid esters, anomeric chiral alkanoic acid esters as well as methods for their preparation and their use in enteral or parenteral nutrition, for metabolic disorder, trauma and malnutrition are described.
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公开(公告)号：ZA9808662B
公开(公告)日：1999-03-31
申请号：ZA9808662
申请日：1998-09-22
Applicant: BAXTER INT
Inventor： HAI TON THAT , NELSON DEANNA J , PEREIRA DAVID E
CPC classification number: A61K38/42
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