公开(公告)号：WO2006081000A3

公开(公告)日：2006-09-28

申请号：PCT/US2005045321

申请日：2005-12-15

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA ,  KIPP JAMES E ,  HAI TON THAT ,  MELNICK BENNETT P

Inventor： KIPP JAMES E ,  HAI TON THAT ,  MELNICK BENNETT P

IPC: C08G65/326 ,  C08G65/334 ,  C08L71/02

CPC classification number: C08G65/334 ,  A61K8/90 ,  A61K9/146 ,  A61K47/34 ,  A61Q19/00 ,  C08G65/326 ,  C08L71/02

Abstract: The present invention is directed to novel compounds, methods of manufacture and methods of use. The present invention is also directed to solid drug/active agent particles having one or more of the compounds of the present invention associated with the surface thereof. The compounds of the present invention are comprised of a non-polar polyether covalently linked to an anionic sulfonate group. The compounds have an amphipathic quality and preferably, are surface active. Such compounds are preferably useful as surface-active agents to coat and stabilize dispersions of particles in a continuous liquid medium. These surface-active agents may be applied in the stabilization of suspensions, emulsions, or liposome formulations intended for pharmaceutical, medical, cosmetic, or agricultural use. The particles that can be prepared by a variety of methods and will preferably comprise a pharmaceutical agent. Pharmaceutical compositions of the present invention can be used to treat amyriad of conditions and can be administered by many routes, including intravenous, intramuscular, subcutaneous, intrathecal, subdural, intracameral, intracerebral, intralesional, topical, oral, buccal, rectal, pulmonary, and nasal.

Abstract translation: 本发明涉及新化合物，制备方法和使用方法。 本发明还涉及具有一种或多种与其表面相关的本发明化合物的固体药物/活性剂颗粒。 本发明的化合物由与阴离子磺酸盐基团共价连接的非极性聚醚组成。 该化合物具有两性质量，优选表面活性。 这些化合物优选用作表面活性剂以涂覆和稳定颗粒在连续液体介质中的分散体。 这些表面活性剂可以用于稳定用于制药，医疗，化妆品或农业用途的悬浮液，乳剂或脂质体制剂。 可以通过多种方法制备并且优选包含药剂的颗粒。 本发明的药物组合物可用于治疗异常的病症，并且可以通过许多途径施用，包括静脉内，肌肉内，皮下，鞘内，硬膜下，阴道内，脑内，肠内，局部，口服，口腔，直肠，肺和 鼻。

公开(公告)号：WO2010022320A3

公开(公告)日：2010-08-19

申请号：PCT/US2009054595

申请日：2009-08-21

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA ,  YANG GUOHAN ,  HAI TON THAT ,  MELNICK BENNETT ,  SAUNDERS PAUL ,  JIANG CONG ,  QUINN CATHERINE ,  LI JIE ,  AMBROISE AROUNAGUIRY ,  BROWN LARRY R

Inventor： YANG GUOHAN ,  HAI TON THAT ,  MELNICK BENNETT ,  SAUNDERS PAUL ,  JIANG CONG ,  QUINN CATHERINE ,  LI JIE ,  AMBROISE AROUNAGUIRY ,  BROWN LARRY R

IPC: A61K47/48 ,  A61P7/00

CPC classification number: A61K47/48215 ,  A61K31/405 ,  A61K47/60

Abstract: The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.

Abstract translation: 本发明涉及聚合衍生物，其可以与含氨基的药物缀合以改善其体内特性。 随后可以释放聚合物衍生物以产生其天然形式的药物。 描述了制备和使用这些聚合物衍生物和药物偶联物的方法。

公开(公告)号：WO2008011581A2

公开(公告)日：2008-01-24

申请号：PCT/US2007074003

申请日：2007-07-20

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA ,  STERNBERG SHMUEL ,  LURVEY KENT L ,  KRONGAUZ VADIM V ,  YEH ROSA H ,  PAULEY ROBIN G ,  CAWTHON DUSTIN C ,  HAI TON THAT ,  WOO LECON L ,  KHANNA ASHOK K ,  LAL BIRENDRA K ,  LING MICHAEL TUNG-KIUNG ,  HOERLE WILLIAM S ,  SANDFORD CRAIG L ,  NORDHAUS MARK A ,  SAVITSKI ALEXANDER ,  KIRICHKOW NICKLAUS J ,  SUH KENNETH GLEN ,  KRISHNAMOORTHY SIVARAMAKRISHNA ,  YANG HSINJIN E ,  CLARKE ROBERT A

Inventor： LURVEY KENT L ,  KRONGAUZ VADIM V ,  YEH ROSA H ,  PAULEY ROBIN G ,  CAWTHON DUSTIN C ,  HAI TON THAT ,  WOO LECON L ,  KHANNA ASHOK K ,  LAL BIRENDRA K ,  LING MICHAEL TUNG-KIUNG ,  HOERLE WILLIAM S ,  SANDFORD CRAIG L ,  NORDHAUS MARK A ,  SAVITSKI ALEXANDER ,  KIRICHKOW NICKLAUS J ,  SUH KENNETH GLEN ,  KRISHNAMOORTHY SIVARAMAKRISHNA ,  YANG HSINJIN E ,  CLARKE ROBERT A

IPC: A61M39/04

CPC classification number: G01N21/78 ,  A61M39/02 ,  A61M39/045 ,  A61M39/16 ,  A61M39/26 ,  A61M2039/1033 ,  A61M2039/1072 ,  A61M2205/583 ,  A61M2205/584 ,  G01N31/22

Abstract: A medical device, such as a vascular access device, is disclosed for providing access to a medical fluid flow path for the introduction or withdrawal of medical fluids to and from the flow path. The access device includes an indicator for providing a visual indication when the access device has been exposed to an antiseptic agent.

Abstract translation: 公开了一种医疗装置，例如血管通路装置，其用于提供通向医疗流体流动路径的入口，以将医疗流体引入流动路径或从流动路径引出。 进入装置包括指示器，用于当进入装置已经暴露于防腐剂时提供视觉指示。

公开(公告)号：WO2009014997A3

公开(公告)日：2010-04-08

申请号：PCT/US2008070410

申请日：2008-07-18

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA ,  HAI TON THAT ,  NORDHAUS MARK A ,  KRONGAUZ VADIM V ,  LURVEY KENT L

Inventor： HAI TON THAT ,  NORDHAUS MARK A ,  KRONGAUZ VADIM V ,  LURVEY KENT L

IPC: A61L29/16

CPC classification number: A61L27/50 ,  A61L27/28 ,  A61L2420/02 ,  A61M39/045 ,  A61M39/16 ,  C07D213/30

Abstract: A method for immobilizing dyes and antimicrobial agents on a porous surface is disclosed and described. The surface may be that of a medical device, such as a catheter, a connector, a drug vial spike, a bag spike, a prosthetic device, an endoscope, and surfaces of an infusion pump. The surfaces may also be one or more of those associated with a dialysis treatment, such as peritoneal dialysis or hemodialysis, where it is important that working surface for the dialysis fluid be sterile. These surfaces include connectors for peritoneal dialysis sets or for hemodialysis sets, bag spikes, dialysis catheters, and so forth. A method for determining whether a surface has been sterilized, and a dye useful in so indicating, is also disclosed.

Abstract translation: 公开并描述了将染料和抗微生物剂固定在多孔表面上的方法。 表面可以是医疗装置，例如导管，连接器，药物瓶尖，袋尖，假体装置，内窥镜和输液泵的表面。 表面也可以是与透析治疗有关的一种或多种，​​例如腹膜透析或血液透析，其中重要的是透析液的工作表面是无菌的。 这些表面包括用于腹膜透析套件的连接器或用于血液透析套件，袋尖，透析导管等。 还公开了一种用于确定表面是否已被灭菌的方法，以及用于如此指示的染料。

公开(公告)号：WO2006081000A9

公开(公告)日：2006-08-31

申请号：PCT/US2005045321

申请日：2005-12-15

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA ,  KIPP JAMES E ,  HAI TON THAT ,  MELNICK BENNETT P

Inventor： KIPP JAMES E ,  HAI TON THAT ,  MELNICK BENNETT P

IPC: C08G65/326 ,  C08G65/334 ,  C08L71/02

CPC classification number: C08G65/334 ,  A61K8/90 ,  A61K9/146 ,  A61K47/34 ,  A61Q19/00 ,  C08G65/326 ,  C08L71/02

Abstract: The present invention is directed to novel compounds, methods of manufacture and methods of use. The present invention is also directed to solid drug/active agent particles having one or more of the compounds of the present invention associated with the surface thereof. The compounds of the present invention are comprised of a non-polar polyether covalently linked to an anionic sulfonate group. The compounds have an amphipathic quality and preferably, are surface active. Such compounds are preferably useful as surface-active agents to coat and stabilize dispersions of particles in a continuous liquid medium. These surface-active agents may be applied in the stabilization of suspensions, emulsions, or liposome formulations intended for pharmaceutical, medical, cosmetic, or agricultural use. The particles that can be prepared by a variety of methods and will preferably comprise a pharmaceutical agent. Pharmaceutical compositions of the present invention can be used to treat amyriad of conditions and can be administered by many routes, including intravenous, intramuscular, subcutaneous, intrathecal, subdural, intracameral, intracerebral, intralesional, topical, oral, buccal, rectal, pulmonary, and nasal.

Abstract translation: 本发明涉及新型化合物，制造方法和使用方法。 本发明还涉及具有与其表面结合的一种或多种本发明化合物的固体药物/活性剂颗粒。 本发明的化合物由与阴离子磺酸盐基团共价连接的非极性聚醚组成。 这些化合物具有两亲性，并且优选具有表面活性。 这些化合物优选用作表面活性剂以涂覆和稳定连续液体介质中的颗粒分散体。 这些表面活性剂可以用于稳定用于药物，医学，化妆品或农业用途的悬浮液，乳液或脂质体制剂。 可以通过多种方法制备并且优选包含药剂的颗粒。 本发明的药物组合物可用于治疗多种病症，并可通过多种途径给药，包括静脉内，肌肉内，皮下，鞘内，硬膜下，前房内，脑内，病灶内，局部，口服，口腔，直肠，肺和 鼻。

公开(公告)号：EP2968676B1

公开(公告)日：2017-05-03

申请号：EP14728708

申请日：2014-03-14

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA ,  UNIV NORTHWESTERN

Inventor： HAI TON THAT ,  GREEN JOHN-BRUCE DEVAULT ,  FULGHUM TIMOTHY MICHAEL ,  MESSERSMITH PHILLIP BYRON ,  SILEIKA TADAS STANISLOVAS

IPC: A61L31/04 ,  A61L27/54 ,  A61L29/16 ,  A61L31/06 ,  A61L31/16 ,  A61L33/00 ,  A61L33/08

CPC classification number: A61L33/0017 ,  A61L27/54 ,  A61L29/06 ,  A61L29/085 ,  A61L29/16 ,  A61L31/048 ,  A61L31/06 ,  A61L31/16 ,  A61L33/0011 ,  A61L33/0094 ,  A61L33/04 ,  A61L33/068 ,  A61L33/08 ,  A61L2300/42 ,  A61L2400/18 ,  A61L2420/02

Abstract: The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, depositing a primer compound on a substrate, thereby forming a primed substrate, contacting the primed substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated primed substrate, and contacting the trihydroxyphenyl-treated primed substrate with a solution of an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the primed substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.

Abstract translation: 本发明提供了将活性剂固定到基底表面的方法，包括以下步骤：将底漆化合物沉积在基底上，由此形成底涂底物，使底涂底物与包含三羟基苯基的化合物溶液接触，从而形成 三羟基苯基处理的底漆底物，并使三羟苯基处理的底漆底物与活性剂溶液接触，由此将活性剂固定在底物上。 还提供了将活性剂固定在基底上的方法，包括以下步骤：提供基底，将包含三羟基苯基的化合物溶液与活性剂溶液合并，由此形成活性剂 - 三羟基苯基缀合物 ，并使底涂底物与活性剂 - 三羟基苯基缀合物的溶液接触，由此将活性剂固定在底物上。 本发明进一步提供了具有固定在其表面上的活性剂的基底和医疗装置或装置部件。

公开(公告)号：EP1017405A4

公开(公告)日：2003-01-22

申请号：EP98931462

申请日：1998-06-22

Applicant: BAXTER INT

Inventor： HAI TON THAT ,  PEREIRA DAVID E ,  NELSON DEANNA J

IPC: A61K38/16 ,  A61K38/00 ,  A61P7/00 ,  A61P43/00 ,  C07G3/00 ,  C07K14/805 ,  C08B37/00 ,  C08G63/48 ,  A61K38/42 ,  A61K47/48 ,  C07H5/06

CPC classification number: C07K14/805 ,  A61K38/00

Abstract: Novel polysaccharide compounds are disclosed for decorating biomolecular surfaces to increase isotropic size and mask antigenicity. The oligosaccharides may by synthesized as repeating disaccharide units, or may be derived by acid hydrolysis of naturally occurring polysaccharides. Such natural sources include chondroitins obtained from shark cartilage, or hyaluronic acid. The polyanionic sulfate groups contained in the sugar moieties impart negative charges which repel the molecules from the negatively charged wall of capillaries, to lengthen retention times of decorated drug molecules, such as cross-linked hemoglobin, in the peripheral circulation.

公开(公告)号：CA2793493A1

公开(公告)日：2011-10-20

申请号：CA2793493

申请日：2011-04-08

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： BUI TUAN ,  HAI TON THAT ,  NORDHAUS MARK ,  SANDERS PAUL ,  JIANG CONG ,  LAMB DAVID ,  YARDIMCI OZLEM

IPC: A61L27/50 ,  A61L27/54 ,  A61L29/14 ,  A61L29/16 ,  A61L31/14 ,  A61L31/16 ,  A61M39/02 ,  A61M39/16

Abstract: A method for immobilizing dyes and antimicrobial agents on a polymeric cover or housing for a medical device is disclosed and described. The surface may be that of a catheter, a connector, a drug vial spike, a bag spike, a prosthetic device, an endoscope, a surface of an infusion pump, a key pad, a touch screen or a handle. The surfaces may also be one or more of those associated with a infusion of a medicament or dialysis treatment, such as peritoneal dialysis or hemodialysis, where it is important that the working surface for the dialysis fluid be sterile. These surfaces include connectors for peritoneal dialysis sets or for hemodialysis sets, bag spikes, dialysis catheters, and so forth. A method for determining whether a surface has been sterilized, and a dye useful in so indicating, is also disclosed.

公开(公告)号：AT520430T

公开(公告)日：2011-09-15

申请号：AT10075249

申请日：2002-10-01

Applicant: BAXTER INT

Inventor： MORTI STAVROULA ,  KAROOR SUJATHA ,  DONOVAN BRIAN ,  HAI TON THAT ,  KATADA MARI ,  LU LUIS ,  MARTIS LEO ,  MUJAIS SALIM ,  SANDERS PAUL ,  SOLTYS PAUL ,  TANDON RAHUL

IPC: A61M1/16 ,  A61M1/36 ,  A61M1/28 ,  B01D15/00 ,  B01J20/02 ,  B01J20/06 ,  B01J20/20 ,  B01J20/22 ,  B01J39/10 ,  B01J41/10

Abstract: The invention provides a device (32) for removing uremic toxins in a dialysis procedure comprising a body having an inlet (42) and an outlet (44) and defining an interior. The interior includes a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon. The device is constructed and arranged so that a fluid entering the device contacts the zirconium phosphate layer before contacting the urease layer and before contacting the zirconium oxide layer.

公开(公告)号：AU742849B2

公开(公告)日：2002-01-17

申请号：AU8158698

申请日：1998-06-22

Applicant: BAXTER INT

Inventor： HAI TON THAT ,  PEREIRA DAVID E ,  NELSON DEANNA J

IPC: A61K38/16 ,  A61K38/00 ,  A61P7/00 ,  A61P43/00 ,  C07G3/00 ,  C07K14/805 ,  C08B37/00 ,  C08G63/48 ,  A61K35/14 ,  A61K39/385 ,  C07H1/00

Abstract: Novel polysaccharide compounds are disclosed for decorating biomolecular surfaces to increase isotropic size and mask antigenicity. The oligosaccharides may be synthesized as repeating disaccharide units, or may be derived by acid hydrolysis of naturally occurring polysaccharides. Such natural sources include chondroitins obtained from shark cartilage, or hyaluronic acid. The polyanionic sulfate groups contained in the sugar moieties impart negative charges which repel the molecules from the negatively charged wall of capillaries, to lengthen retention times of decorated drug molecules, such as crosslinked hemoglobin, in the peripheral circulation.