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    3.
    发明专利
    未知

    公开(公告)号：DE69736974T2

    公开(公告)日：2007-05-03

    申请号：DE69736974

    申请日：1997-09-22

    Applicant: BAXTER INT

    Inventor： PRINCE R ,  PEKKARINEN O ,  BELLAMY DAVID ,  STERNBERG SHMUEL

    IPC: B01D65/02 ,  A61M1/26 ,  A61M1/34 ,  B01D39/16 ,  B01D61/14 ,  B01D61/22 ,  B01D63/16 ,  B01D65/08 ,  B01D69/00 ,  B01D69/02

    Abstract: A method and apparatus for filtering suspensions of medical and biological fluids, one aspect of which is separating a suspension comprising at least two types of particles which are differently sized or shaped and in which the first type of particle may be deformable at a relatively lower force and/or faster rate than the second type of particle. A filter member is provided having substantially precisely dimensioned pore sizes, with the pores being dimensioned to allow passage of the first type of suspended particle without distortion or only minimal distortion and passage of the second type of particle only with substantial distortion. Because the filter membrane has precisely dimensioned pores, with spacing between the pores being maintained despite the smaller interval between the pores, the porosity of the membrane may be much greater than nominal pore size membranes, allowing faster filtration rates and/or smaller membranes for a given filtration rate, while reducing the exposure time of the cells within the shear environment, and consequently reducing particle damage. Various methods for preventing clogging of the membrane are also disclosed.

    4.
    发明专利
    未知

    公开(公告)号：DE69736974D1

    公开(公告)日：2007-01-04

    申请号：DE69736974

    申请日：1997-09-22

    Applicant: BAXTER INT

    Inventor： PRINCE R ,  PEKKARINEN O ,  BELLAMY DAVID ,  STERNBERG SHMUEL

    IPC: B01D65/02 ,  A61M1/26 ,  A61M1/34 ,  B01D39/16 ,  B01D61/14 ,  B01D61/22 ,  B01D63/16 ,  B01D65/08 ,  B01D69/00 ,  B01D69/02

    Abstract: A method and apparatus for filtering suspensions of medical and biological fluids, one aspect of which is separating a suspension comprising at least two types of particles which are differently sized or shaped and in which the first type of particle may be deformable at a relatively lower force and/or faster rate than the second type of particle. A filter member is provided having substantially precisely dimensioned pore sizes, with the pores being dimensioned to allow passage of the first type of suspended particle without distortion or only minimal distortion and passage of the second type of particle only with substantial distortion. Because the filter membrane has precisely dimensioned pores, with spacing between the pores being maintained despite the smaller interval between the pores, the porosity of the membrane may be much greater than nominal pore size membranes, allowing faster filtration rates and/or smaller membranes for a given filtration rate, while reducing the exposure time of the cells within the shear environment, and consequently reducing particle damage. Various methods for preventing clogging of the membrane are also disclosed.

    6.
    发明专利
    未知

    公开(公告)号：DE3784347D1

    公开(公告)日：1993-04-01

    申请号：DE3784347

    申请日：1987-02-25

    Applicant: BAXTER INT

    Inventor： WILLIAMSON WARREN ,  PRINCE R

    IPC: A61M1/02 ,  A61M1/00 ,  A61M1/36 ,  A61M5/38 ,  A61M37/00 ,  A61M39/14

    Abstract: The method comprises placing a needle (12 or 14) in fluid communication with a chamber, and introducing a liq. into the chamber through the needles and allowing the liq. to exit the chamber and flow back into the network, so that the tubing system is purged with the liq. The method comprises enclosing at least a distal region of the needles within a common chamber (16), and flowing liq. through one portion of the tubing system and into the chamber via one of the needles. The method then involves flowing liq. out from the chamber via the other of the needles, so that air in the tubing system is purged. The method further comprises collecting air in the chamber during the flowing step and venting the collected air from the chamber.

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