中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

21 records (took 0.021 seconds)

    Composiciones particuladas de inhibidores de tubulina
    1.
    发明专利
    Composiciones particuladas de inhibidores de tubulina 未知

    公开(公告)号：ES2424255T3

    公开(公告)日：2013-09-30

    申请号：ES05851355

    申请日：2005-11-03

    Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

    Inventor： PAPADOPOULOS PAVLOS ,  DOTY MARK ,  KIPP JAMES E ,  ROESSLER BERTHOLD

    IPC: A61K31/404 ,  A61K9/00 ,  A61P35/00

    Abstract: Composición farmacéutica en partículas que incluye partículas con un tamaño medio efectivo de entreaproximadamente 15 nm y aproximadamente 50 micrómetros de al menos un inhibidor de la tubulina defórmula (1): donde X es R3 es arilo o heteroarilo; R3' es hidrógeno; R4, R5, R6 y R7 son independientemente hidrógeno, halógeno o alquilo; R1 es arilalquilo; y R2 es hidrógeno, alquilo, acilo, arilo, alcoxicarbonilo, ariloxicarbonilo, heteroariloxicarbonilo, cicloalcoxicarbonilo,heterocicloalcoxicarbonilo, alqueniloxicarbonilo, cicloalqueniloxicarbonilo y heterocicloalqueniloxi-carbonilo; yal menos un agente tensioactivo seleccionado de entre el grupo consistente en agentes tensioactivos noiónicos, agentes tensioactivos aniónicos, agentes tensioactivos catiónicos, agentes tensioactivos derivadosbiológicamente, agentes tensioactivos zwitteriónicos y aminoácidos.

    6.
    发明专利
    未知

    公开(公告)号：BRPI0517652A

    公开(公告)日：2008-10-14

    申请号：BRPI0517652

    申请日：2005-11-03

    Applicant: BAXTER HEALTHCARE SA ,  BAXTER INT

    Inventor： RAAB GERHARD ,  PAPADOPOULOS PAVLOS ,  DOTY MARK ,  KIPP JAMES E ,  ROESSLER BERTHOLD

    IPC: A61K31/404 ,  A61K9/00 ,  A61P35/00

    Abstract: The present invention is directed to novel pharmaceutical compositions comprising nano- and micro-particulate formulations of poorly water soluble tubulin inhibitors of the indole chemical class, preferably N-substituted indol-3-glyoxyamides, and more preferably N-(Pyridin-4-yl)-[1-(4-chlorobenzyl)-indol-3-yl]glyoxylic acid amide (D-24851), also known as “Indibulin,” and methods of making and using such compositions for the treatment of anti-tumor agent resistant cancers and other diseases.

    7.
    发明专利
    未知

    公开(公告)号：BRPI0409929A

    公开(公告)日：2006-04-25

    申请号：BRPI0409929

    申请日：2004-04-29

    Applicant: BAXTER INT

    Inventor： RABINOW BARRETT E ,  WHITE RANDY ,  SUN CHONG-SON ,  WONG JOSEPH CHUNG TAK ,  KIPP JAMES E ,  DOTY MARK J ,  REBBECK CHRISTINE L ,  PAPADOPOULOS PAVLOS

    IPC: A61K9/50 ,  A61K9/51 ,  A61K31/496 ,  A61K9/14

    Abstract: The present invention relates to compositions of submicron- to micron-size particles of antimicrobial agents. More particularly the invention relates to a composition of an antimicrobial agent that renders the agent potent against organisms normally considered to be resistant to the agent. The composition comprises an aqueous suspension of submicron-tomicron-size particles containing the agent coated with at least one surfactant selected from the group consisting of: ionic surfactants, non-ionic surfactants, biologically derived surfactants, and amino acids and their derivatives. The particles have a volume-weighted mean particle size of less than 5 µm as measured by laser diffractonetry.

Patent Agency Ranking