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1.发明申请
公开(公告)号：WO2006089651A3
公开(公告)日：2007-01-11
申请号：PCT/EP2006001248
申请日：2006-02-10
Applicant: BAXTER INT , BAXTER HEALTHCARE SA , ROESSLER BERTHOLD
Inventor： ROESSLER BERTHOLD
IPC: A61K9/00 , A61K9/28 , A61K31/675
CPC classification number: A61K9/2866 , A61K9/2846 , A61K31/675
Abstract: The invention relates to trofosfamide-containing film-coated tablets for oral administration as well as a method for the production thereof.
Abstract translation: 本发明涉及氯乙环磷酰胺含有用于口服给药的以及用于它们的制备方法的膜包衣片。
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2.发明申请
公开(公告)号：WO2006002887A8
公开(公告)日：2006-06-08
申请号：PCT/EP2005006991
申请日：2005-06-29
Applicant: BAXTER INT , BAXTER HEALTHCARE SA , ROESSLER BERTHOLD
Inventor： ROESSLER BERTHOLD
IPC: A61K9/08 , A61K31/4439 , A61K47/12
CPC classification number: A61K47/12
Abstract: The invention relates to a pharmaceutical presentation form for the oral administration of a poorly soluble active compound (D-24 851; INN: indibulin) in the form of an aqueous drink solution, and a method for its preparation.
Abstract translation: 本发明涉及以饮用水溶液形式口服不溶性活性化合物（D-24 851; INN：靛蓝）的药物呈递形式及其制备方法。
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3.发明申请ORAL SOLID PHARMACEUTICAL FORMULATION OF THE TRIBULIN INHIBITOR INDIBULIN 审中-公开TRIBULIN抑制剂INDIBULIN的口服固体药物制剂
公开(公告)号：WO2006133835A3
公开(公告)日：2007-07-19
申请号：PCT/EP2006005423
申请日：2006-06-07
Applicant: BAXTER INT , BAXTER HEALTHCARE SA , ROESSLER BERTHOLD , RAAB GERHARD , REISSMANN THOMAS
Inventor： ROESSLER BERTHOLD , RAAB GERHARD , REISSMANN THOMAS
IPC: A61K9/16 , A61K31/4439
CPC classification number: A61K9/1623 , A61K9/1652 , A61K31/4439
Abstract: The present invention relates to a pharmaceutical formulation for oral administration of the poorly soluble and therefore hardly bioavailable tubulin inhibitor Indibulin and a process for its manufacture. In particular, there is provided a pharmaceutical formulation of lndibulin for oral administration comprising a granulate containing micronized lndibulin having a particle size of less than 20 µm for at least 99 vol.-% of the particles, at least one hydrophilic surfactant, and one or more capsulation excipients.
Abstract translation: 本发明涉及一种用于口服给予难溶性且因此难以生物利用的微管蛋白抑制剂靛敏素的药物制剂及其制备方法。 特别地，提供了用于口服给药的依地普林的药物制剂，其包含含有至少99体积％的颗粒，至少一种亲水性表面活性剂和至少一种亲水性表面活性剂的粒径小于20μm的微粉化丝氨酸的颗粒，以及一种或 更多的胶囊赋形剂。
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公开(公告)号：CA2598759C
公开(公告)日：2013-08-06
申请号：CA2598759
申请日：2006-02-10
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： ROESSLER BERTHOLD
IPC: A61K9/00 , A61K9/28 , A61K31/675
Abstract: The invention relates to trofosfamide-containing film-coated tablets for oral administration as well as a method for the production thereof.
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5.发明专利
公开(公告)号：PT1853218E
公开(公告)日：2013-07-23
申请号：PT06706868
申请日：2006-02-10
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： ROESSLER BERTHOLD
IPC: A61K9/00 , A61K9/28 , A61K31/675
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Patent Agency Ranking
公开(公告)号：MX2007016081A
公开(公告)日：2008-03-10
申请号：MX2007016081
申请日：2006-06-07
Applicant: BAXTER INT
Inventor： REISSMANN THOMAS , ROESSLER BERTHOLD , RAAB GERHARD
IPC: A61K9/16 , A61K31/4439
Abstract: La presente invencion se refiere a una formulacion farmaceutica para administracion oral de un inhibidor de tubulina, Indubulina, pobremente soluble y por lo tanto escasamente biodisponible y un procedimiento para su fabricacion. En particular, se proporciona una formulacion farmaceutica de Indibulina para administracion oral, que comprende un granulo que contiene Indibulina micronizada teniendo un tamano de particula de menos de 20 ??m para por lo menos 99%/volumen de las particulas, por lo menos un agente tensoactivo, y uno o mas excipientes de encapsulacion.
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公开(公告)号：CA2598759A1
公开(公告)日：2006-08-31
申请号：CA2598759
申请日：2006-02-10
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： ROESSLER BERTHOLD
IPC: A61K9/00 , A61K9/28 , A61K31/675
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公开(公告)号：DK1853218T3
公开(公告)日：2013-09-23
申请号：DK06706868
申请日：2006-02-10
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： ROESSLER BERTHOLD
IPC: A61K9/00 , A61K9/28 , A61K31/675
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公开(公告)号：PL1667655T3
公开(公告)日：2012-05-31
申请号：PL04789095
申请日：2004-09-28
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： ROESSLER BERTHOLD
IPC: A61K9/08 , A61K9/19 , A61K31/185 , A61K31/66 , A61K31/675 , A61K45/06 , A61K47/20 , A61K47/26 , A61P35/00
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公开(公告)号：HK1091146A1
公开(公告)日：2007-01-12
申请号：HK06113073
申请日：2006-11-29
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： ROESSLER BERTHOLD
IPC: A61K20060101 , A61K9/08 , A61K9/19 , A61K31/185 , A61K31/66 , A61K31/675 , A61K45/06 , A61K47/20 , A61K47/26 , A61P20060101 , A61P35/00
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