公开(公告)号：WO0050035A2

公开(公告)日：2000-08-31

申请号：PCT/US0001588

申请日：2000-01-21

Applicant: BAXTER INT

Inventor： THOMPSON STACEY S ,  CHILAMKURTI RAO ,  SAMUEL MARY K ,  STEPHENS NORMA

IPC: A61K9/00 ,  A61K31/43 ,  A61K31/431 ,  A61K31/495 ,  A61K31/496 ,  A61K47/12 ,  A61K47/26 ,  A61K9/08

CPC classification number: A61K47/26 ,  A61K9/0019 ,  A61K31/43 ,  A61K31/431 ,  A61K31/495 ,  A61K31/496 ,  A61K47/12 ,  A61K2300/00

Abstract: The present invention provides a premixed form of a buffered piperacillin product having a near neutral pH and capable of a shelf life of at least nine months, with freezer storage (-20 DEG C or lower), or a refrigerated shelf life of up to 14 days at about 5 DEG C. The piperacillin may additionally contain a tazobactam component to inactivate beta-lactamases that commonly cause resistance to penicillins, allowing the piperacillin component to destroy susceptible bacteria. With the addition of dextrose, the premixed composition is physiologically isosmotic.

Abstract translation: 本发明提供一种具有接近中性pH并且能够保存至少9个月的缓冲哌拉西林产品的预混合形式，具有冷藏储存（-20℃或更低）或冷藏保质期长达14 约5℃的天数。哌拉西林可以另外含有他唑巴坦成分以灭活通常对青霉素产生抗性的β-内酰胺酶，允许哌拉西林组分破坏易感染的细菌。 通过加入葡萄糖，预混组合物在生理上是等渗的。

公开(公告)号：CY1108966T1

公开(公告)日：2014-07-02

申请号：CY091100433

申请日：2009-04-13

Applicant: BAXTER INT

Inventor： THOMPSON STACEY S ,  CHILAMKURTI RAO ,  SAMUEL MARY K ,  STEPHENS NORMA

IPC: A61K31/43 ,  A61K9/00 ,  A61K9/08 ,  A61K31/431 ,  A61K31/495 ,  A61K31/496 ,  A61K47/12 ,  A61K47/26

Abstract: Ηπαρούσαεφεύρεσηαφοράπροαναμεμιγμένημορφήενόςρυθμισμένουπροϊόντοςπιπερασιλλίνηςπουέχεισχεδόνουδέτερο pΗκαιικανόμιαςδιάρκειαςφύλαξηςστοράφι, τουλάχιστονεννέαμηνών, μεφύλαξησεκαταψύκτη (-20°C ήμικρότερη) ήδιάρκειαςφύλαξηςστοράφιυπόψύξημέχρι 14 ημέρεςπερίπουστους 5 C. Ηπιπερασιλλίνημπορείεπιπροσθέτωςναπεριέχειένασυστατικόταζοβακτάμηγιανααπενεργοποιείβήτα-λακταμάσεςπουκοινώςπροκαλούναντοχήστιςπενικιλίνες, επιτρέπονταςστοσυστατικόπιπερασιλλίνηνακαταστρέφειεπιδεκτικάβακτηρίδια. Μετηνπροσθήκηδεξτρόζης, ηπροαναμεμιγμένησύνθεσηείναιφυσιολογικώςισο-οσμωτική.

公开(公告)号：DE60041868D1

公开(公告)日：2009-05-07

申请号：DE60041868

申请日：2000-01-21

Applicant: BAXTER INT

Inventor： THOMPSON STACEY S ,  CHILAMKURTI RAO ,  SAMUEL MARY K ,  STEPHENS NORMA

IPC: A61K31/43 ,  A61K9/00 ,  A61K9/08 ,  A61K31/431 ,  A61K31/495 ,  A61K31/496 ,  A61K47/12 ,  A61K47/26

Abstract: The present invention provides a premixed form of a buffered piperacillin product having a near neutral pH and capable of a shelf life of at least nine months, with freezer storage (-20° C. or lower), or a refrigerated shelf life of up to 14 days at about 5° C. The piperacillin may additionally contain a tazobactam component to inactivate beta-lactamases that commonly cause resistance to penicillins, allowing the piperacillin component to destroy susceptible bacteria. With the addition of dextrose, the premixed composition is physiologically isosmotic.

公开(公告)号：PT1154770E

公开(公告)日：2009-04-27

申请号：PT00906992

申请日：2000-01-21

Applicant: BAXTER INT

Inventor： THOMPSON STACEY S ,  CHILAMKURTI RAO ,  SAMUEL MARY K ,  STEPHENS NORMA

IPC: A61K31/43 ,  A61K9/00 ,  A61K9/08 ,  A61K31/431 ,  A61K31/495 ,  A61K31/496 ,  A61K47/12 ,  A61K47/26

公开(公告)号：CA2361392C

公开(公告)日：2007-08-07

申请号：CA2361392

申请日：2000-01-21

Applicant: BAXTER INT

Inventor： CHILAMKURTI RAO ,  SAMUEL MARY K ,  STEPHENS NORMA ,  THOMPSON STACEY S

IPC: A61K31/496 ,  A61K9/00 ,  A61K9/08 ,  A61K31/43 ,  A61K31/431 ,  A61K31/495 ,  A61K47/12 ,  A61K47/26 ,  A61P31/04

Abstract: The present invention provides a premixed form of a buffered piperacillin product having a near neutral pH and capable of a shelf life of at least nine months, with freezer storage (-20 .degree.C or lower), or a refrigerated shelf life of up to 14 days at about 5 .degree.C. The piperacillin may additionally contain a tazobactam component to inactivate beta-lactamases that commonly cause resistance to penicillins, allowing the piperacillin component to destroy susceptible bacteria. With the addition of dextrose, the premixed composition is physiologically isosmotic.

公开(公告)号：AU2856200A

公开(公告)日：2000-09-14

申请号：AU2856200

申请日：2000-01-21

Applicant: BAXTER INT

Inventor： THOMPSON STACEY S ,  CHILAMKURTI RAO ,  SAMUEL MARY K ,  STEPHENS NORMA

IPC: A61K9/00 ,  A61K31/43 ,  A61K31/431 ,  A61K31/495 ,  A61K31/496 ,  A61K47/12 ,  A61K47/26 ,  A61K9/08

Abstract: The present invention provides a premixed form of a buffered piperacillin product having a near neutral pH and capable of a shelf life of at least nine months, with freezer storage (-20° C. or lower), or a refrigerated shelf life of up to 14 days at about 5° C. The piperacillin may additionally contain a tazobactam component to inactivate beta-lactamases that commonly cause resistance to penicillins, allowing the piperacillin component to destroy susceptible bacteria. With the addition of dextrose, the premixed composition is physiologically isosmotic.

公开(公告)号：ES2322790T3

公开(公告)日：2009-06-29

申请号：ES00906992

申请日：2000-01-21

Applicant: BAXTER INT

Inventor： THOMPSON STACEY S ,  CHILAMKURTI RAO ,  SAMUEL MARY K ,  STEPHENS NORMA

IPC: A61K31/43 ,  A61K9/00 ,  A61K9/08 ,  A61K31/431 ,  A61K31/495 ,  A61K31/496 ,  A61K47/12 ,  A61K47/26

Abstract: Composición farmacéutica adecuada para su administración parenteral que comprende una solución que posee una cantidad eficaz de piperacilina, teniendo dicha solución un pH ajustado para que se encuentre en el rango de 6,1 a 6,9, caracterizada porque la composición comprende además una cantidad eficaz de un tampón para mantener el pH en el rango de 6,1 a 6,9.

公开(公告)号：DK1154770T3

公开(公告)日：2009-06-29

申请号：DK00906992

申请日：2000-01-21

Applicant: BAXTER INT

Inventor： THOMPSON STACEY S ,  CHILAMKURTI RAO ,  SAMUEL MARY K ,  STEPHENS NORMA

IPC: A61K31/43 ,  A61K9/00 ,  A61K9/08 ,  A61K31/431 ,  A61K31/495 ,  A61K31/496 ,  A61K47/12 ,  A61K47/26

Abstract: The present invention provides a premixed form of a buffered piperacillin product having a near neutral pH and capable of a shelf life of at least nine months, with freezer storage (-20° C. or lower), or a refrigerated shelf life of up to 14 days at about 5° C. The piperacillin may additionally contain a tazobactam component to inactivate beta-lactamases that commonly cause resistance to penicillins, allowing the piperacillin component to destroy susceptible bacteria. With the addition of dextrose, the premixed composition is physiologically isosmotic.

公开(公告)号：CA2361392A1

公开(公告)日：2000-08-31

申请号：CA2361392

申请日：2000-01-21

Applicant: BAXTER INT

Inventor： THOMPSON STACEY S ,  CHILAMKURTI RAO ,  SAMUEL MARY K ,  STEPHENS NORMA

IPC: A61K9/00 ,  A61K31/43 ,  A61K31/431 ,  A61K31/495 ,  A61K31/496 ,  A61K47/12 ,  A61K47/26 ,  A61K9/08

Abstract: The present invention provides a premixed form of a buffered piperacillin product having a near neutral pH and capable of a shelf life of at least nin e months, with freezer storage (-20 ~C or lower), or a refrigerated shelf life of up to 14 days at about 5 ~C. The piperacillin may additionally contain a tazobactam component to inactivate beta-lactamases that commonly cause resistance to penicillins, allowing the piperacillin component to destroy susceptible bacteria. With the addition of dextrose, the premixed compositio n is physiologically isosmotic.