公开(公告)号：WO0050035A2

公开(公告)日：2000-08-31

申请号：PCT/US0001588

申请日：2000-01-21

Applicant: BAXTER INT

Inventor： THOMPSON STACEY S ,  CHILAMKURTI RAO ,  SAMUEL MARY K ,  STEPHENS NORMA

IPC: A61K9/00 ,  A61K31/43 ,  A61K31/431 ,  A61K31/495 ,  A61K31/496 ,  A61K47/12 ,  A61K47/26 ,  A61K9/08

CPC classification number: A61K47/26 ,  A61K9/0019 ,  A61K31/43 ,  A61K31/431 ,  A61K31/495 ,  A61K31/496 ,  A61K47/12 ,  A61K2300/00

Abstract: The present invention provides a premixed form of a buffered piperacillin product having a near neutral pH and capable of a shelf life of at least nine months, with freezer storage (-20 DEG C or lower), or a refrigerated shelf life of up to 14 days at about 5 DEG C. The piperacillin may additionally contain a tazobactam component to inactivate beta-lactamases that commonly cause resistance to penicillins, allowing the piperacillin component to destroy susceptible bacteria. With the addition of dextrose, the premixed composition is physiologically isosmotic.

Abstract translation: 本发明提供一种具有接近中性pH并且能够保存至少9个月的缓冲哌拉西林产品的预混合形式，具有冷藏储存（-20℃或更低）或冷藏保质期长达14 约5℃的天数。哌拉西林可以另外含有他唑巴坦成分以灭活通常对青霉素产生抗性的β-内酰胺酶，允许哌拉西林组分破坏易感染的细菌。 通过加入葡萄糖，预混组合物在生理上是等渗的。

公开(公告)号：EP0680358A4

公开(公告)日：1996-07-31

申请号：EP94931282

申请日：1994-09-20

Applicant: BAXTER INT

Inventor： THOMPSON STACEY S ,  MCSHANE JAMES ,  WONG JOSEPH ,  WOOD RAY W

IPC: A61J1/05 ,  A61J1/00 ,  A61J1/20 ,  A61M5/14 ,  A61M5/28 ,  A61M37/00 ,  A61M39/00

CPC classification number: A61M5/284 ,  A61J1/10 ,  A61J1/1475 ,  A61J1/201 ,  A61J1/2013 ,  A61J1/2089 ,  A61J1/2096 ,  A61M5/1409 ,  A61M5/282

Abstract: A receptacle (500) is provided for coupling an adaptor (10) having a vial (54) including a beneficial agent to an IV administration set (526). In an embodiment, the receptacle (500) includes an injection site (512) for receiving a cannula (26) from the adaptor (10). A resilient divider (516) separates the receptacle (500) into two sections defined by an upper fitment (508) and a lower fitment (510). A container (520) holding a solution is in fluid communication with the receptacle (500) via an inlet (502). A through bore (518) allows the solution from the container (520) to pass through the resilient divider (516) when the adaptor (10) is removed from the receptacle (500).

公开(公告)号：AU681718B2

公开(公告)日：1997-09-04

申请号：AU8010794

申请日：1994-09-20

Applicant: BAXTER INT

Inventor： THOMPSON STACEY S ,  MCSHANE JAMES ,  WONG JOSEPH ,  WOOD RAY W

IPC: A61J1/05 ,  A61J1/00 ,  A61J1/20 ,  A61M5/14 ,  A61M5/28 ,  A61M37/00 ,  A61M39/00 ,  A61M39/02

公开(公告)号：CY1108966T1

公开(公告)日：2014-07-02

申请号：CY091100433

申请日：2009-04-13

Applicant: BAXTER INT

Inventor： THOMPSON STACEY S ,  CHILAMKURTI RAO ,  SAMUEL MARY K ,  STEPHENS NORMA

IPC: A61K31/43 ,  A61K9/00 ,  A61K9/08 ,  A61K31/431 ,  A61K31/495 ,  A61K31/496 ,  A61K47/12 ,  A61K47/26

Abstract: Ηπαρούσαεφεύρεσηαφοράπροαναμεμιγμένημορφήενόςρυθμισμένουπροϊόντοςπιπερασιλλίνηςπουέχεισχεδόνουδέτερο pΗκαιικανόμιαςδιάρκειαςφύλαξηςστοράφι, τουλάχιστονεννέαμηνών, μεφύλαξησεκαταψύκτη (-20°C ήμικρότερη) ήδιάρκειαςφύλαξηςστοράφιυπόψύξημέχρι 14 ημέρεςπερίπουστους 5 C. Ηπιπερασιλλίνημπορείεπιπροσθέτωςναπεριέχειένασυστατικόταζοβακτάμηγιανααπενεργοποιείβήτα-λακταμάσεςπουκοινώςπροκαλούναντοχήστιςπενικιλίνες, επιτρέπονταςστοσυστατικόπιπερασιλλίνηνακαταστρέφειεπιδεκτικάβακτηρίδια. Μετηνπροσθήκηδεξτρόζης, ηπροαναμεμιγμένησύνθεσηείναιφυσιολογικώςισο-οσμωτική.

公开(公告)号：AU8010794A

公开(公告)日：1995-06-13

申请号：AU8010794

申请日：1994-09-20

Applicant: BAXTER INT

Inventor： THOMPSON STACEY S ,  MCSHANE JAMES ,  WONG JOSEPH ,  WOOD RAY W

IPC: A61J1/05 ,  A61J1/00 ,  A61J1/20 ,  A61M5/14 ,  A61M5/28 ,  A61M37/00 ,  A61M39/00

公开(公告)号：DE60041868D1

公开(公告)日：2009-05-07

申请号：DE60041868

申请日：2000-01-21

Applicant: BAXTER INT

Inventor： THOMPSON STACEY S ,  CHILAMKURTI RAO ,  SAMUEL MARY K ,  STEPHENS NORMA

IPC: A61K31/43 ,  A61K9/00 ,  A61K9/08 ,  A61K31/431 ,  A61K31/495 ,  A61K31/496 ,  A61K47/12 ,  A61K47/26

Abstract: The present invention provides a premixed form of a buffered piperacillin product having a near neutral pH and capable of a shelf life of at least nine months, with freezer storage (-20° C. or lower), or a refrigerated shelf life of up to 14 days at about 5° C. The piperacillin may additionally contain a tazobactam component to inactivate beta-lactamases that commonly cause resistance to penicillins, allowing the piperacillin component to destroy susceptible bacteria. With the addition of dextrose, the premixed composition is physiologically isosmotic.

公开(公告)号：PT1154770E

公开(公告)日：2009-04-27

申请号：PT00906992

申请日：2000-01-21

Applicant: BAXTER INT

Inventor： THOMPSON STACEY S ,  CHILAMKURTI RAO ,  SAMUEL MARY K ,  STEPHENS NORMA

IPC: A61K31/43 ,  A61K9/00 ,  A61K9/08 ,  A61K31/431 ,  A61K31/495 ,  A61K31/496 ,  A61K47/12 ,  A61K47/26

公开(公告)号：CA2152586A1

公开(公告)日：1995-06-01

申请号：CA2152586

申请日：1994-09-20

Applicant: BAXTER INT

Inventor： THOMPSON STACEY S ,  MCSHANE JAMES ,  WONG JOSEPH ,  WOOD RAY W

IPC: A61J1/05 ,  A61J1/00 ,  A61J1/20 ,  A61M5/14 ,  A61M5/28 ,  A61M37/00 ,  A61M39/00

Abstract: A receptacle (500) is provided for coupling an adaptor (10) having a vial (54) including a beneficial agent to an IV administration set (526). In an embodiment, the receptacle (500) includes an injection site (512) for receiving a cannula (26) from the adaptor (10). A resilient divider (516) separates the receptacle (500) into two sections defined by an upper fitment (508) and a lower fitment (510). A container (520) holding a solution is in fluid communication with the receptacle (500) via an inlet (502). A through bore (518) allows the solution from the container (520) to pass through the resilient divider (516) when the adaptor (10) is removed from the receptacle (500).

公开(公告)号：ES2322790T3

公开(公告)日：2009-06-29

申请号：ES00906992

申请日：2000-01-21

Applicant: BAXTER INT

Inventor： THOMPSON STACEY S ,  CHILAMKURTI RAO ,  SAMUEL MARY K ,  STEPHENS NORMA

IPC: A61K31/43 ,  A61K9/00 ,  A61K9/08 ,  A61K31/431 ,  A61K31/495 ,  A61K31/496 ,  A61K47/12 ,  A61K47/26

Abstract: Composición farmacéutica adecuada para su administración parenteral que comprende una solución que posee una cantidad eficaz de piperacilina, teniendo dicha solución un pH ajustado para que se encuentre en el rango de 6,1 a 6,9, caracterizada porque la composición comprende además una cantidad eficaz de un tampón para mantener el pH en el rango de 6,1 a 6,9.

公开(公告)号：DK1154770T3

公开(公告)日：2009-06-29

申请号：DK00906992

申请日：2000-01-21

Applicant: BAXTER INT

Inventor： THOMPSON STACEY S ,  CHILAMKURTI RAO ,  SAMUEL MARY K ,  STEPHENS NORMA

IPC: A61K31/43 ,  A61K9/00 ,  A61K9/08 ,  A61K31/431 ,  A61K31/495 ,  A61K31/496 ,  A61K47/12 ,  A61K47/26

Abstract: The present invention provides a premixed form of a buffered piperacillin product having a near neutral pH and capable of a shelf life of at least nine months, with freezer storage (-20° C. or lower), or a refrigerated shelf life of up to 14 days at about 5° C. The piperacillin may additionally contain a tazobactam component to inactivate beta-lactamases that commonly cause resistance to penicillins, allowing the piperacillin component to destroy susceptible bacteria. With the addition of dextrose, the premixed composition is physiologically isosmotic.