公开(公告)号：HK1144548A1

公开(公告)日：2011-02-25

申请号：HK10111026

申请日：2010-11-26

Applicant: BAXTER INT

Inventor： RISER BRUCE L ,  ZIESKE PAUL ,  KAROOR SUJATHA ,  PATEL HIMANSHU D

IPC: A61K20060101 ,  A61L20060101 ,  A61M20060101 ,  A61P20060101

Abstract: Dialysis solutions comprising pyrophosphates and methods of making and using the dialysis solutions are provided. In an embodiment, the present disclosure provides a dialysis solution comprising a stable and therapeutically effective amount of pyrophosphate. The dialysis solution can be sterilized, for example, using a technique such as autoclave, steam, high pressure, ultra-violet, filtration or combination thereof. The dialysis solution can be in the form of a concentrate.

公开(公告)号：CA2510788A1

公开(公告)日：2004-07-15

申请号：CA2510788

申请日：2003-12-18

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： CHOO CAROLYN ,  ZIESKE PAUL ,  MARTIS LEO

IPC: A61K31/718 ,  A61K31/724 ,  A61M1/28

Abstract: Glucose polymer-based solutions and methods of making same that can be used during medical therapy, such as dialysis therapy are provided. The glucose polymer-based solution preferably includes a first solution containing icodextrin at a pH ranging from about 1.5 to about 5.0 and a buffer solution at a pH ranging from about 7.0 to about 12.0 that are so constructed and arranged allowing the glucose polymer-based solution to be mixed prior to infusion into a patient. The glucose polymer-based solutions of the present invention can be made at physiologic pH and with minimal glucose degradation products.

公开(公告)号：DK2211874T3

公开(公告)日：2014-02-17

申请号：DK08838014

申请日：2008-10-07

Applicant: BAXTER HEALTHCARE SA ,  BAXTER INT

Inventor： KAROOR SUJATHA ,  PATEL HIMANSHU D ,  RISER BRUCE L ,  ZIESKE PAUL

IPC: A61K33/42 ,  A61L2/00 ,  A61L2/02 ,  A61L2/04 ,  A61L2/07 ,  A61L2/10 ,  A61M1/16 ,  A61M1/28 ,  A61P7/08

公开(公告)号：AU2012216797B2

公开(公告)日：2013-10-31

申请号：AU2012216797

申请日：2012-09-12

Applicant: BAXTER HEALTHCARE SA ,  BAXTER INT

Inventor： RISER BRUCE L ,  ZIESKE PAUL ,  KAROOR SUJATHA ,  PATEL HIMANSHU D

IPC: A61K33/42 ,  A61L2/02 ,  A61L2/04 ,  A61L2/07 ,  A61L2/10 ,  A61M1/16 ,  A61M1/28 ,  A61P7/08

Abstract: A heat sterilized solution includes a pyrophosphate and a bicarbonate buffer, the solution having a pH greater than 7, wherein the bicarbonate buffer and the pH greater than 7 heat stabilize the pyrophosphate. The solution can be part of a heat sterilized dialysis product that also includes another part comprising a dialysis component selected from the group consisting of osmotic agents, electrolytes and combinations thereof. 1 1 Inn- 1)

公开(公告)号：CA2701763A1

公开(公告)日：2009-04-16

申请号：CA2701763

申请日：2008-10-07

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： RISER BRUCE L ,  ZIESKE PAUL ,  KAROOR SUJATHA ,  PATEL HIMANSHU D

IPC: A61K33/42 ,  A61L2/02 ,  A61L2/04 ,  A61L2/07 ,  A61L2/10 ,  A61M1/16 ,  A61M1/28 ,  A61P7/08

Abstract: Dialysis solutions comprising pyrophosphates and methods of making and using the dialysis solutions are provided. In an embodiment, the present disclosure provides a dialysis solution comprising a stable and therapeutically effective amount of pyrophosphate. The dialysis solution can be sterilized, for example, using a technique such as autoclave, steam, high pressure, ultra-violet, filtration or combination thereof. The dialysis solution can be in the form of a concentrate.

公开(公告)号：BR0317450A

公开(公告)日：2005-11-16

申请号：BR0317450

申请日：2003-12-18

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： MARTIS LEO ,  CHOO CAROLYN ,  ZIESKE PAUL

IPC: A61K31/718 ,  A61K31/724 ,  A61M1/28

Abstract: Icodextrin-based solutions and methods of making same that can be used during medical therapy, such as dialysis therapy are provided. The icodextrin-based solution at least includes a first solution containing icodextrin at a pH ranging from about 1.5 to about 5.0 and a buffer solution at a pH ranging from about 7.0 to about 12.0 that are so constructed and arranged allowing the icodextrin-based solution to be mixed prior to infusion into a patient. The icodextrin-based solutions of the present invention can be made at physiologic pH and with minimal glucose degradation products.

公开(公告)号：CA2701763C

公开(公告)日：2017-04-18

申请号：CA2701763

申请日：2008-10-07

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： RISER BRUCE L ,  ZIESKE PAUL ,  KAROOR SUJATHA ,  PATEL HIMANSHU D

IPC: A61K33/42 ,  A61L2/02 ,  A61L2/04 ,  A61L2/07 ,  A61L2/10 ,  A61M1/16 ,  A61M1/28 ,  A61P7/08

Abstract: Dialysis solutions comprising pyrophosphates and methods of making and using the dialysis solutions are provided. In an embodiment, the present disclosure provides a dialysis solution comprising a stable and therapeutically effective amount of pyrophosphate. The dialysis solution can be sterilized, for example, using a technique such as autoclave, steam, high pressure, ultra-violet, filtration or combination thereof. The dialysis solution can be in the form of a concentrate.

公开(公告)号：BRPI0818250A2

公开(公告)日：2015-04-07

申请号：BRPI0818250

申请日：2008-10-07

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： RISER BRUCE L ,  ZIESKE PAUL ,  KAROOR SUJATHA ,  PATEL HIMANSHU D

IPC: A61K33/42 ,  A61L2/02 ,  A61L2/04 ,  A61L2/07 ,  A61L2/10 ,  A61M1/16 ,  A61M1/28 ,  A61P7/08

公开(公告)号：AU2008311054B2

公开(公告)日：2012-10-18

申请号：AU2008311054

申请日：2008-10-07

Applicant: BAXTER HEALTHCARE SA ,  BAXTER INT

Inventor： RISER BRUCE L ,  KAROOR SUJATHA ,  PATEL HIMANSHU D ,  ZIESKE PAUL

IPC: A61K33/42 ,  A61L2/02 ,  A61L2/04 ,  A61L2/07 ,  A61L2/10 ,  A61M1/16 ,  A61M1/28 ,  A61P7/08

Abstract: Dialysis solutions comprising pyrophosphates and methods of making and using the dialysis solutions are provided. In an embodiment, the present disclosure provides a dialysis solution comprising a stable and therapeutically effective amount of pyrophosphate. The dialysis solution can be sterilized, for example, using a technique such as autoclave, steam, high pressure, ultra-violet, filtration or combination thereof. The dialysis solution can be in the form of a concentrate.

公开(公告)号：CO6270333A2

公开(公告)日：2011-04-20

申请号：CO10056067

申请日：2010-05-11

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： RISER BRUCE L ,  ZIESKE PAUL ,  KAROOR SUJATHA ,  PATEL HIMANSHU

IPC: A61K33/42 ,  A61L2/02 ,  A61L2/04 ,  A61L2/10 ,  A61P7/08

Abstract: Se proporcionan soluciones para dialisis que comprenden pirofosfatos y métodos para elaborar y utilizar las soluciones para dialisis. En una modalidad, la presente descripcion suministra unas soluciones para dialisis que comprenden una cantidad estable y terapéuticamente efectiva de pirofosfatos. La solucion para dialisis se puede esterilizar, por ejemplo, utilizando una técnica tal como autoclave, vapor, alta presion, rayos ultra-violeta, filtracion o una combinacion de las mismas. La solucion para dialisis puede estar en la forma de un concentrado.