公开(公告)号：WO1992019355A1

公开(公告)日：1992-11-12

申请号：PCT/US1992003475

申请日：1992-04-27

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  BUCHHOLZ, Donald, H. ,  KANDLER, Richard, L.

IPC: B01D37/00

CPC classification number: A61K35/18 ,  A61M1/0218 ,  A61M2202/0429 ,  A61M2205/7518 ,  A61M2202/0042 ,  A61M2202/005

Abstract: A blood processing method provides a red blood cell product that is free of microorganisms like Yersinia enterocolitica during storage periods over 24 hours. The red blood cell product is collected in a first container (16), where it is refrigerating to cool the blood product to a temperature of about 3 to 5 degrees C. The refrigerated product is transferred from the first container (16) into a storage container (34) through a prescribed filter medium (44) that comprises a mass of synthetic fibers having an average fiber diameter of about 10 microns or less and a bulk density of about 0.7 gram per cubic centimeter or less. The filtered product is retained in the storage container (34) at a temperature of about 3 to 5 degrees C for a storage period over 24 hours after filtration. Using the filter medium (44), microorganisms like Yersinia enterocolitica present in the red blood cell product at the time of collection are depleted. The filtered blood product remains free of clinically significant numbers of microorganisms throughout refrigerated storage up to time of transfusion.

Abstract translation: 血液处理方法提供在24小时内储存期间不含微生物如小肠结肠炎耶尔森菌的红细胞产物。 将红细胞产品收集在第一容器（16）中，在该第一容器（16）中，其被冷藏以将血液制品冷却至约3至5摄氏度的温度。冷藏产品从第一容器（16）转移到储存器 容器（34）通过规定的过滤介质（44），所述过滤介质包括大量的平均纤维直径约为10微米或更小，体积密度为约0.7克/立方厘米或更小的合成纤维。 过滤后的产物在约3〜5℃的温度下保存在储存容器（34）中24小时以上。 使用过滤介质（44），在收集时存在于红细胞产品中的微生物诸如肠球菌耶尔森菌（Yersinia enterocolitica）被耗尽。 过滤的血液制品在输血时间内，在冷藏保存期间，仍然无临床显着数量的微生物。

公开(公告)号：WO1992002239A1

公开(公告)日：1992-02-20

申请号：PCT/US1991005219

申请日：1991-07-24

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  KANDLER, Richard, L. ,  SPICUSSA, John, C.

IPC: A61K37/02

CPC classification number: A61K38/42

Abstract: The present invention relates to a stable hemoglobin based composition having sufficiently low levels of methemoglobin to effectively function as an oxygen carrying solution upon administration to a patient made by the process comprising: a) adding an oxygenated or deoxygenated form of said blood substitute to an oxygen impermeable package, and b) storing said container at from between 5 DEG C to 45 DEG C for sufficient time to permit the autoreduction of methemoglobin. The stable hemoglobin based composition includes hemoglobin, modified hemoglobin and/or encapsulated hemoglobin. To effectively function as an oxygen carrying solution upon administration to a patient, the stable hemolobin based solution cannot have greater than about 50 % of said hemoglobin based solution in the methemoglobin form but, preferably no more than about 15 %. The invention further relates to a method to store a stable oxygen carrying solution according to the above discussed process.

Abstract translation: 本发明涉及一种稳定的基于血红蛋白的稳定的组合物，其具有足够低水平的高铁血红蛋白，以便在施用于通过该方法制备的患者时有效起氧载体溶液的作用，所述方法包括：a）将氧合或脱氧形式的所述血液代用品加入氧气 不可渗透的包装，以及b）将所述容器在5℃至45℃之间储存足够的时间以允许高铁血红蛋白的自身还原。 基于稳定血红蛋白的组合物包括血红蛋白，修饰的血红蛋白和/或包封的血红蛋白。 为了在给予患者时有效地作为携氧溶液起作用，稳定的基于血红蛋白的溶液不能具有高于血红蛋白形式的所述基于血红蛋白的溶液的约50％，但优选不超过约15％。 本发明还涉及一种根据上述方法储存稳定的载氧溶液的方法。

公开(公告)号：EP0541790B1

公开(公告)日：1995-08-02

申请号：EP92917351.6

申请日：1992-04-27

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BUCHHOLZ, Donald, H. ,  KANDLER, Richard, L.

IPC: B01D37/00 ,  A61M1/02

CPC classification number: A61K35/18 ,  A61M1/0218 ,  A61M2202/0429 ,  A61M2205/7518 ,  A61M2202/0042 ,  A61M2202/005

Abstract: A blood processing method provides a red blood cell product that is free of microorganisms like Yersinia enterocolitica during storage periods over 24 hours. The red blood cell product is collected in a first container, where it is refrigerating to cool the blood product to a temperature of about 3 to 5 degrees C. The refrigerated product is transferred from the first container into a storage container through a prescribed filter medium that comprises a mass of synthetic fibers having an average fiber diameter of about 10 microns or less and a bulk density of about 0.7 gram per cubic centimeter or less. The filtered product is retained in the storage container at a temperature of about 3 to 5 degrees C. for a storage period over 24 hours after filtration. Using the filter medium, microorganisms like Yersinia enterocolitica present in the red blood cell product at the time of collection are depleted. The filtered blood product remains free of clinically significant numbers of microorganisms throughout refrigerated storage up to time of transfusion.

公开(公告)号：EP0495047A1

公开(公告)日：1992-07-22

申请号：EP91913972.0

申请日：1991-07-24

Applicant: BAXTER INTERNATIONAL INC.

Inventor： KANDLER, Richard, L. ,  SPICUSSA, John, C.

IPC: A61K38 ,  A61P7

CPC classification number: A61K38/42

Abstract: L'invention se rapporte à une composition stable à base d'hémoglobine comportant des niveaux de méthémoglobine suffisamment faibles pour fonctionner efficacement comme solution porteuse d'oxygène quand on l'administre à un malade et qui est produite au moyen d'un processus comprenant: a) l'addition d'une forme oxygénée ou désoxygénée dudit substitut sanguin à un ensemble de conditionnement imperméable oxygéné et, b) le stockage dudit ensemble à une température située entre 5 °C et 45 °C pendant une période suffisamment longue pour permettre l'autoréduction de la méthémoglobine. La composition stable à base d'hémoglobine comprend de l'hémoglobine, de l'hémoglobine modifiée et/ou encapsulée. Pour fonctionner efficacement comme solution porteuse d'oxygène quand on l'administre à un malade, cette solution stable à base d'hémoglobine ne peut comporter plus de 50 % environ de ladite solution à base d'hémoglobine sous forme de méthémoglobine mais, de préférence, pas plus de 15 % environ. L'invention se rapporte, de plus, à un procédé de stockage d'une solution stable porteuse d'oxygène en rapport avec le processus décrit ci-dessus.

公开(公告)号：EP1001675A1

公开(公告)日：2000-05-24

申请号：EP98921239.4

申请日：1998-05-15

Applicant: BAXTER INTERNATIONAL INC.

Inventor： KANDLER, Richard, L. ,  FARRELL, Liam, C.

IPC: A01N1/02

CPC classification number: A01N1/0226 ,  A01N1/02 ,  A01N1/0205

Abstract: Platelet suspensions and methods for resuspending platelet concentrates are disclosed. The platelet concentrates are resuspended by combining a platelet concentrate with a substance capable of resuspending platelets, such as a salt solution. The resuspended platelets may be stored and/or administered to a patient.

公开(公告)号：EP0495047B1

公开(公告)日：1995-11-29

申请号：EP91913972.5

申请日：1991-07-24

Applicant: BAXTER INTERNATIONAL INC.

Inventor： KANDLER, Richard, L. ,  SPICUSSA, John, C.

IPC: A61K38/42 ,  A61K35/18

CPC classification number: A61K38/42

Abstract: The present invention relates to a stable hemoglobin based composition having sufficiently low levels of methemoglobin to effectively function as an oxygen carrying solution upon administration to a patient made by the process comprising: a) adding an oxygenated or deoxygenated form of said blood substitute to an oxygen impermeable package, and b) storing said container at from between 5 °C to 45 °C for sufficient time to permit the autoreduction of methemoglobin. The stable hemoglobin based composition includes hemoglobin, modified hemoglobin and/or encapsulated hemoglobin. To effectively function as an oxygen carrying solution upon administration to a patient, the stable hemolobin based solution cannot have greater than about 50 % of said hemoglobin based solution in the methemoglobin form but, preferably no more than about 15 %. The invention further relates to a method to store a stable oxygen carrying solution according to the above discussed process.