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公开(公告)号：WO2019195568A8
公开(公告)日：2019-10-10
申请号：PCT/US2019/025816
申请日：2019-04-04
Applicant: BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE SA
Inventor： LO, Ying-Cheng , BROWN, Aaron W. , DING, Yuanpang Samuel , LAO, Alex , FULLER, Zachariah Louis , GEIER, Aaron Joseph , HARVEY, Alan John , LO, Leansu Kiatoukaysy
IPC: A61M1/28
Abstract: A gravity fed peritoneal dialysis ("PD") machine includes: a frame configured to be set on a supporting surface; at least one load cell; a scale platform supported by the frame via the at least one load cell positioned between the frame and the scale platform; a drain container support in mechanical communication with and extending downwardly from the scale platform, the machine configured such that when the frame is set on the supporting surface, at least one fresh PD fluid supply container is supportable by the scale platform above the at least one load cell and at least one used PD fluid drain container is supportable by the drain container support below the at least one load cell, so that a combined weight of fresh PD fluid and used PD fluid may be sensed by the at least one load cell.
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2.发明申请HEMODIALYSIS AND PERITONEAL DIALYSIS SYSTEMS HAVING ELECTRODIALYSIS AND ELECTRODEIONIZATION CAPABILITIES 审中-公开具有电解质和电极化能力的血液透析和腹膜透析系统
公开(公告)号：WO2014158418A1
公开(公告)日：2014-10-02
申请号：PCT/US2014/016376
申请日：2014-02-14
Applicant: BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE SA
Inventor： LIN, Rongsheng , DING, Yuanpang Samuel , WHITE, James M. , CHEN, Ye , LO, Ying-Cheng , MILLER, Joshua , ROHDE, Justin
IPC: A61M1/16
CPC classification number: A61M1/1696 , A61M1/284 , C02F1/4693 , C02F1/4695 , C02F2103/026
Abstract: Systems and methods for hemodialysis or peritoneal dialysis having integrated electrodialysis and electrodeionization capabilities are provided. In an embodiment, the dialysis system includes a carbon source, a urease source, an ED/EDI unit. The carbon source, urease source, and/or the ED/EDI unit can be in the form of removable cartridges.
Abstract translation: 提供具有综合电渗析和电去离子能力的用于血液透析或腹膜透析的系统和方法。 在一个实施方案中，透析系统包括碳源，脲酶源，ED / EDI单元。 碳源，脲酶源和/或ED / EDI单元可以是可移除的盒的形式。
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公开(公告)号：WO2012036836A4
公开(公告)日：2012-03-22
申请号：PCT/US2011/048202
申请日：2011-08-18
Applicant: BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE S. A. , CHILDERS, Robert, W. , LO, Ying-Cheng , HOPPING, Peter
Inventor： CHILDERS, Robert, W. , LO, Ying-Cheng , HOPPING, Peter
IPC: A61M1/28
Abstract: The present system and method in one embodiment limit a maximum instantaneous peritoneal volume to a comfortable level, while allowing the dialysis machine to advance to fill a prescribed volume whenever the drain ends after a minimum drain percentage has been attained. If a low drain condition occurs, the nominal fill volume is lowered and a therapy cycle is added, so that a prescribed total amount of fresh therapy fluid is used during therapy, maximizing therapeutic benefit. An allowable residual volume at the end of an incomplete drain is increased, thereby lowering the probability of a subsequent low drain condition.
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4.发明申请THERAPY PREDICTION AND OPTIMIZATION FOR RENAL FAILURE BLOOD THERAPY, ESPECIALLY HOME HEMODIALYSIS 审中-公开治疗失败血液治疗的治疗预防和优化，特别是家庭心脏病学
公开(公告)号：WO2011130669A1
公开(公告)日：2011-10-20
申请号：PCT/US2011/032736
申请日：2011-04-15
Applicant: BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE S.A. , AKONUR, Alp , LEYPOLDT, John, Kenneth , LO, Ying-Cheng , AGAR, Baris, Ugar
Inventor： AKONUR, Alp , LEYPOLDT, John, Kenneth , LO, Ying-Cheng , AGAR, Baris, Ugar
CPC classification number: A61M1/16 , A61M1/1613 , A61M1/1619 , A61M2202/0498 , A61M2205/15 , A61M2205/505 , A61M2205/52
Abstract: A renal failure blood therapy system includes: (i) a renal failure blood therapy machine; (ii) a therapy prescription for a patient treated by the renal failure blood therapy machine to remove a solute from the patient's blood; (iii) a test including multiple blood samples taken at multiple times during a test therapy to determine concentration levels of the solute at each of the multiple times; and (iv) a device programmed to use a kinetic model for the solute in a first instance with at least one of the concentration levels of the solute to estimate at least one estimated patient parameter. The device is further programmed to enable a user to determine at least one of a therapy duration, a therapy frequency, a dialysate flowrate or a blood flowrate for the therapy prescription.
Abstract translation: 肾衰竭血液治疗系统包括：（i）肾衰竭血液治疗机; （ii）由肾衰竭血液治疗机治疗的患者的治疗处方，以从患者血液中除去溶质; （iii）包括在测试治疗期间多次采集的多个血液样本的测试以确定多次中的每一次的溶质的浓度水平; 以及（iv）被编程为在第一种情况下使用溶质的动力学模型的装置，其中至少一个所述溶质的浓度水平估计至少一个估计的患者参数。 该装置还被编程为使得用户能够确定用于治疗处方的治疗持续时间，治疗频率，透析液流量或血液流速中的至少一个。
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公开(公告)号：WO2010096657A1
公开(公告)日：2010-08-26
申请号：PCT/US2010/024742
申请日：2010-02-19
Applicant: BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE S.A. , LO, Ying-Cheng , VISHNOI, Rohit
Inventor： LO, Ying-Cheng , VISHNOI, Rohit
IPC: A61M1/28
Abstract: A peritoneal dialysis method includes (i) connecting smaller and larger supply containers to a junction, the smaller and larger supply bags both full of dialysate; (ii) allowing the junction to be connected to a patient's transfer set; allowing the patient to drain through the junction; (iii) allowing the patient to fill from the smaller supply container; and (iv) allowing the patient to refill the smaller supply container from the larger supply container.
Abstract translation: 腹膜透析方法包括（i）将较小和较大的供应容器连接到交界处，较小和较大的充满透析液的供应袋; （ii）允许接头连接到患者的转移组件; 允许患者通过交界处排出; （iii）允许患者从较小的供应容器中填充; 和（iv）允许患者将更小的供应容器从较大的供应容器中重新填充。
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Patent Agency Ranking6.发明申请
公开(公告)号：WO2010059959A2
公开(公告)日：2010-05-27
申请号：PCT/US2009/065367
申请日：2009-11-20
Applicant: BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE S.A. , LO, Ying-Cheng , DING, Yuanpang Samuel
Inventor： LO, Ying-Cheng , DING, Yuanpang Samuel
CPC classification number: A61M1/28 , A61M39/20 , A61M2205/10 , A61M2205/12 , A61M2205/121 , A61M2205/505 , A61M2205/7536
Abstract: A medical fluid or dialysis system includes an auto-connection mechanism that connects connectors from the supply bags to dialysis cassette ports or cassette supply lines. The system provides for multiple, e.g., four, supply bags, which can be connected to a manifold of the auto-connection mechanism. Tip protecting caps that protect the supply line ends and cassette ports or cassette supply line ends are made to be compatible with the auto-connection mechanism. The auto-connection mechanism removes all the caps and connects the supply lines to the cassette. At least one roller occluder is provided that occludes the supply tubing prior to the tip protecting caps being removed. The roller occludes prevent medical dialysis fluid from spilling out of the supply lines between the time that the caps are removed and connection to the cassette is made.
Abstract translation: 医疗流体或透析系统包括自动连接机构，其将来自供应袋的连接器连接到透析盒端口或盒供应线。 该系统提供多个（例如四个）供应袋，其可连接到自动连接机构的歧管。 保护电源线末端和盒式磁带端口或盒式磁带供电线末端的保护盖可以与自动连接机制兼容。 自动连接机制将所有盖帽取下并将供应线连接到盒带。 提供至少一个滚轮封堵器，在移除顶端保护帽之前封堵供应管。 滚筒堵塞防止医用透析液在取下盖子和与盒子连接之间溢出供应管线。
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公开(公告)号：WO1996011033A1
公开(公告)日：1996-04-18
申请号：PCT/US1995012121
申请日：1995-09-22
Applicant: BAXTER INTERNATIONAL INC.
IPC: A61M39/28
CPC classification number: F16L11/121 , A61M39/08 , A61M39/28
Abstract: A tubing (10) having members (12, 14) located on the inside surface (16) of a tubing. The flow through the tubing (10) is easily and completely occluded when the tubing is clamped, due to the members (12, 14) filling channels (18, 20) around the clamped site. Reduced clamping pressure is required to fully occlude the flow through the tubing (10). The tubing (10) undergoes less deformation upon clamping and returns to its pre-clamped form easily upon recovery.
Abstract translation: 具有位于管道的内表面（16）上的构件（12,14）的管道（10）。 由于构件（12,14）填充夹紧位置周围的通道（18,20），当管道被夹紧时，通过管道（10）的流动容易且完全闭塞。 需要降低夹紧压力以完全堵塞通过管道（10）的流动。 管道（10）在夹紧时经历较少的变形，并且在恢复时容易恢复到预夹紧形式。
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公开(公告)号：WO2019018203A1
公开(公告)日：2019-01-24
申请号：PCT/US2018/041811
申请日：2018-07-12
Applicant: BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE SA
Inventor： DING, Yuanpang, Samuel , MINKUS, Marc, Steven , LO, Ying-Cheng , DOTY, Mark, Joseph , DUDAR, Thomas, Edward , BOMGAARS, Grant, Anthony , PASMORE, Mark, Edward , SADOWSKI, Michael, Joseph , HRISTAKOS, Anastasios , KRAUSE, Bernd , RANALLETTA, Joseph, Vincent
Abstract: A syringe system includes a syringe and a filtration device connected to the syringe for sterilizing and introducing fluid into the syringe. The syringe includes a syringe barrel having a proximal end defining a barrel opening, a distal end defining a delivery opening, a bore extending between the proximal end and the distal end, and a stopper disposed in the bore of the syringe barrel. The filtration device has an inlet and an outlet coupled in fluid communication with the delivery opening at the distal end of the syringe barrel. The filtration device includes a stem and a filter membrane disposed in line with the stem. The filter membrane optionally has a plurality of pores each with a nominal pore size in a range of approximately 0.1 μm to approximately 0.5 μm such that a pharmaceutical fluid can be introduced as a sterilized pharmaceutical fluid into the bore of the syringe barrel by passing through the filtration device.
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公开(公告)号：WO2019018200A1
公开(公告)日：2019-01-24
申请号：PCT/US2018/041807
申请日：2018-07-12
Applicant: BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE SA
Inventor： SCHUCK, David, Filiberto , CAZZINI, Karl, Hans , DING, Yuanpang, Samuel , LO, Ying-Cheng , BOMGAARS, Grant, Anthony , DUDAR, Thomas, Edward , PASMORE, Mark, Edward , KRAUSE, Bernd , SADOWSKI, Michael, Joseph , HRISTAKOS, Anastasios , RANALLETTA, Joseph, Vincent
Abstract: A medical product includes a bladder, a filtration device, and a sterile product concentrate. The bladder has a perimeter seal and defining a sterile chamber. The filtration device includes a stem and a filter membrane disposed in line with the stem. The stem extends through the perimeter seal and has an inlet end accessible from outside of the perimeter seal and an outlet end in fluid communication with the sterile chamber. The filter membrane can have a nominal pore size in a range of approximately 0.1 μm to approximately 0.5 μm, wherein the filter membrane is shaped as a hollow fiber with a wall and pores residing in the wall of the fiber. The sterile product concentrate is disposed in the sterile chamber and adapted to be reconstituted by the introduction of a pharmaceutical fluid into the chamber through the filtration device.
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公开(公告)号：WO2017127632A1
公开(公告)日：2017-07-27
申请号：PCT/US2017/014264
申请日：2017-01-20
Applicant: BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE SA
Inventor： BOMGAARS, Grant, Anthony , RANALLETTA, Joseph, Vincent , DING, Yuanpang, Samuel , LO, Ying-Cheng , PASMORE, Mark, Edward , SADOWSKI, Michael, Joseph , HRISTAKOS, Anastasios , DUDAR, Thomas, Edward , KRAUSE, Bernd
CPC classification number: B65B3/003 , B65B31/024 , B65B43/60
Abstract: A method of providing filled product bags of sterile and particulate-free fluid includes securing a product bag to one of a plurality of movable cradles, wherein the product bag has a bladder, a stem fluidly connected to an opening of the bladder, and a filter disposed in-line with the stem. After securing the bag, an inlet of the stem is connected to an outlet of a nozzle assembly and at least partially filling the product bag with a fluid through a nozzle of the nozzle assembly to create a filled product bag, wherein filling the product bag includes passing the fluid through the filter and into the bladder. After filling, the stem of the filled product bag is sealed at a location below the filter. The stem is cut at a location above the seal and below the filter. The method including performing an integrity test on the filter, removing the filled product bag from the cradle, and depositing the filled product bag into a first bin for rejected bags if the filter fails the integrity test and a second bin for accepted bags if filter passes the integrity test.
Abstract translation: 一种提供无菌和无颗粒流体的填充产品袋的方法包括将产品袋固定到多个可移动支架中的一个，其中产品袋具有囊袋，茎杆流体连接到 膀胱的打开以及与杆排列成直线的过滤器。 在固定袋子之后，将杆的入口连接到喷嘴组件的出口，并且通过喷嘴组件的喷嘴至少部分地用流体填充产品袋以形成填充的产品袋，其中填充产品袋包括 使流体通过过滤器并进入膀胱。 填充后，填充的产品袋的茎在过滤器下方的位置密封。 杆在密封件上方和过滤器下方的位置切割。 该方法包括在过滤器上执行完整性测试，从托架中取出已填充的产品袋，并且如果过滤器未通过完整性测试，则将填充后的产品袋放入第一垃圾箱，如果过滤器通过 完整性测试。
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